Cellular elasticity in cancer: a review of altered biomechanical features DOI
Bakeel A. Radman,

Alaa Majeed Mutashar Alhameed,

Guang Shu

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(22), P. 5299 - 5324

Published: Jan. 1, 2024

A large number of studies have shown that changes in biomechanical characteristics are an important indicator tumor transformation normal cells. Elastic deformation is one the more studied features cells, which plays role tumourigenesis and development. Altered cell elasticity often brings many indications. This manuscript reviews effects altered cellular on characteristics, including adhesion viscosity, migration, proliferation, differentiation stiffness. Also, physical factors may affect elasticity, such as temperature, height, cell-viscosity, aging, summarized. Then, cell-matrix, cytoskeleton, vitro culture medium, cell-substrate with different three-dimensional structures during tumorigenesis outlined. Importantly, we summarize current signaling pathways well tests for elastic deformation. Finally, hybrid materials: polymer-polymer, protein-protein, protein-polymer hybrids, also, nano-delivery strategies target resilience cases at least clinical phase 1 trials. Overall, behavior cancer modulated by biological, chemical, changes, turn potential to alter this be encouraging prediction future discovery therapies.

Language: Английский

Lift force in odd compressible fluids DOI Creative Commons

Ruben Lier,

Charlie Duclut, Stefano Bo

et al.

Physical review. E, Journal Year: 2023, Volume and Issue: 108(2)

Published: Aug. 2, 2023

When a body moves through fluid, it can experience force orthogonal to its movement called lift force. Odd viscous fluids break parity and time-reversal symmetry, suggesting the existence of an odd on tracer particles, even at vanishing Reynolds numbers for symmetric geometries. It was previously found that incompressible fluid cannot induce particle with no-slip boundary conditions, making signatures viscosity in two-dimensional bulk elusive. By computing response matrix particle, we show compressible produce Using shell localization, provide analytic expressions drag forces acting steady state also finite frequency. Importantly, find requires taking into account nonconservation mass density due coupling between surface three-dimensional fluid.

Language: Английский

Citations

22

Colloidal Self‐Assembly: From Passive to Active Systems DOI Creative Commons
Yaxin Huang, Changjin Wu, Jingyuan Chen

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 63(9)

Published: Dec. 8, 2023

Self-assembly fundamentally implies the organization of small sub-units into large structures or patterns without intervention specific local interactions. This process is commonly observed in nature, occurring at various scales ranging from atomic/molecular assembly to formation complex biological structures. Colloidal particles may serve as micrometer-scale surrogates for studying assembly, particularly poorly understood kinetic and dynamic processes atomic scale. Recent advances colloidal self-assembly have enabled programmable creation novel materials with tailored properties. We here provide an overview comparison both passive active self-assembly, a discussion on energy landscape interactions governing types. In realm many impressive important been realized, including molecules, one-dimensional chains, two-dimensional lattices, three-dimensional crystals. contrast, driven by optical, electric, chemical, other fields, involves more intricate processes, offering flexibility potential new applications. A comparative analysis underscores critical distinctions between assemblies, highlighting unique collective behaviors emerging systems. These encompass motion, motility-induced phase segregation, exotic properties arising out-of-equilibrium thermodynamics. Through this comparison, we aim identify future opportunities research, which suggest application domains.

Language: Английский

Citations

20

Lorentz Reciprocal Theorem in Fluids with Odd Viscosity DOI Creative Commons
Yuto Hosaka, Ramin Golestanian, Andrej Vilfan

et al.

Physical Review Letters, Journal Year: 2023, Volume and Issue: 131(17)

Published: Oct. 25, 2023

The Lorentz reciprocal theorem—that is used to study various transport phenomena in hydrodynamics—is violated chiral active fluids that feature odd viscosity with broken time-reversal and parity symmetries. Here, we show the theorem can be generalized by choosing an auxiliary problem opposite sign of viscosity. We demonstrate application two categories microswimmers. Swimmers prescribed surface velocity are not affected viscosity, while those forces are. In particular, a torque dipole lead directed motion.Received 24 May 2023Accepted 29 September 2023DOI:https://doi.org/10.1103/PhysRevLett.131.178303Published American Physical Society under terms Creative Commons Attribution 4.0 International license. Further distribution this work must maintain attribution author(s) published article's title, journal citation, DOI. Open access publication funded Max Planck Society.Published SocietyPhysics Subject Headings (PhySH)Research AreasChiralityLow Reynolds number flowsPhysical SystemsLiving matter & matterMicroswimmersPropertiesViscosityFluid Dynamics

Language: Английский

Citations

17

Dissipation, quantum coherence, and asymmetry of finite-time cross-correlations DOI Creative Commons
Tan Van Vu, Van Tuan Vo, Keiji Saito

et al.

Physical Review Research, Journal Year: 2024, Volume and Issue: 6(1)

Published: March 12, 2024

Recent studies have revealed a deep connection between the asymmetry of cross-correlations and thermodynamic quantities in short-time limit. In this study, we address finite-time domain for both open classical quantum systems. Focusing on Markovian dynamics, show that observed is upper bounded by dissipation. We prove that, systems steady state with arbitrary operational durations, exhibits, at most, linear growth over time, speed determined rates entropy production dynamical activity. long-time regime, exhibits exponential decay, decay rate spectral gap transition matrix. Remarkably, cases, coherence equally important as dissipation constraining correlations. demonstrate an example where only bounds while vanishes. Furthermore, generalize correlation asymmetry, reported Shiraishi [] Ohga [], to encompass scenarios. These findings offer insights into aspects asymmetry. Published American Physical Society 2024

Language: Английский

Citations

8

Cellular elasticity in cancer: a review of altered biomechanical features DOI
Bakeel A. Radman,

Alaa Majeed Mutashar Alhameed,

Guang Shu

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(22), P. 5299 - 5324

Published: Jan. 1, 2024

A large number of studies have shown that changes in biomechanical characteristics are an important indicator tumor transformation normal cells. Elastic deformation is one the more studied features cells, which plays role tumourigenesis and development. Altered cell elasticity often brings many indications. This manuscript reviews effects altered cellular on characteristics, including adhesion viscosity, migration, proliferation, differentiation stiffness. Also, physical factors may affect elasticity, such as temperature, height, cell-viscosity, aging, summarized. Then, cell-matrix, cytoskeleton, vitro culture medium, cell-substrate with different three-dimensional structures during tumorigenesis outlined. Importantly, we summarize current signaling pathways well tests for elastic deformation. Finally, hybrid materials: polymer-polymer, protein-protein, protein-polymer hybrids, also, nano-delivery strategies target resilience cases at least clinical phase 1 trials. Overall, behavior cancer modulated by biological, chemical, changes, turn potential to alter this be encouraging prediction future discovery therapies.

Language: Английский

Citations

8