Oxidative stress and mitochondrial damage in lambda-cyhalothrin toxicity: A comprehensive review of antioxidant mechanisms

Environmental Pollution, Journal Year: 2023, Volume and Issue: 338, P. 122694 - 122694

Published: Oct. 4, 2023

Lambda-cyhalothrin, also known as cyhalothrin, is an efficient, broad-spectrum, quick-acting pyrethroid insecticide and acaricide the most powerful in world. However, there increasing evidence that lambda-cyhalothrin closely related to a variety of toxicity drawbacks (hepatotoxicity, nephrotoxicity, neurotoxicity reproductive toxicity, among others) non-target organisms, oxidative stress seems be main mechanism toxicity. This manuscript reviews mitochondrial damage induced by signalling pathways involved this process, indicating occupies important position The antioxidants alleviate discussed. In addition, metabolites major metabolic enzymes reactions are summarized. review article reveals key toxicity-oxidative suggests use effective method for preventing

Language: Английский

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Comprehensive analysis of the overexpressed cytochrome P450-based insecticide resistance mechanism in Spodoptera litura

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 461, P. 132605 - 132605

Published: Sept. 22, 2023

Language: Английский

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European grapevine moth, Lobesia botrana Part II: Prevention and management

Entomologia Generalis, Journal Year: 2023, Volume and Issue: 43(2), P. 281 - 304

Published: April 28, 2023

Lobesia botrana (Denis & Schiffermüller) (Lepidoptera: Tortricidae), commonly known as the European grapevine moth (EGVM), is a primary pest of vineyards.This article provides an updated review its monitoring, modelling, and management tools.EGVM strategies analysed here include insecticide-based control, insecticide resistance, side-effects (particularly those caused by exposure to sublethal doses pesticides), cultural sterile insect technique, pheromone-mediated control (with special reference pheromone-based mating disruption), biological area-wide programs.Lastly, we outline significant challenges for future EGVM research sustainable implementation.

Language: Английский

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Transcriptional regulation and overexpression of GST cluster enhances pesticide resistance in the cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae)

Communications Biology, Journal Year: 2023, Volume and Issue: 6(1)

Published: Oct. 19, 2023

The rapid evolution of resistance in agricultural pest poses a serious threat to global food security. However, the mechanisms through metabolic regulation are largely unknown. Here, we found that GST gene cluster was strongly selected North China (NTC) population, and it significantly genetically-linked lambda-cyhalothrin resistance. Knockout using CRISPR/Cas9 increased sensitivity knockout strain lambda-cyhalothrin. Haplotype analysis revealed no non-synonymous mutations or structural variations cluster, whereas GST_119 GST_121 were overexpressed NTC population. Silencing co-silencing with RNAi larval We also identified additional GATAe transcription factor binding sites promoter NTC_GST_119. Transient expression Hi5 cells activated NTC_GST_119 Xinjiang (XJ)_GST_119 transcription, but transcriptional activity higher than XJ_GST_119. These results demonstrate regulatory region result complex changes which enhances field-populations. This study deepens our knowledge evolutionary mechanism adaptation under environmental stress provides potential targets for monitoring integrated management.

Language: Английский

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Cuticular competing endogenous RNAs regulate insecticide penetration and resistance in a major agricultural pest

BMC Biology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 4, 2023

The continuously developing pesticide resistance is a great threat to agriculture and human health. Understanding the mechanisms of insecticide key step in dealing with phenomenon. Insect cuticle recently documented delay xenobiotic penetration which breaks previous stereotype that useless resistance, while underlying mechanism remains scarce.Here, we find integument contributes over 40.0% via different delivery strategies oriental fruit fly. A negative relationship exists between thickening resistant/susceptible, also field strains fly reason for integument-mediated resistance. Our investigations uncover regulator miR-994 mimic treatment causes thinning increases susceptibility malathion, whereas inhibitor results opposite phenotypes. target most abundant protein (CPCFC) resistant/susceptible expression profile, possesses capability chitin-binding influences thickness-mediated penetration. analyses an upstream transcriptional regulatory signal cascade, long noncoding RNA (lnc19419), indirectly upregulates CPCFC resistant strain by sponging miR-994. Thus, elucidate cuticular competing endogenous RNAs regulating demonstrate it fly.We unveil axis lnc19419 ~ on thickness leads These findings indicate regulate modulating provide insight into insects.

Language: Английский

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Behavioral resistance to insecticides: current understanding, challenges, and future directions

Current Opinion in Insect Science, Journal Year: 2024, Volume and Issue: 63, P. 101177 - 101177

Published: Feb. 13, 2024

Identifying and understanding behavioral resistance to insecticides is vital for maintaining global food security, public health, ecological balance. Behavioral has been documented occur in a multitude of insect taxa dating back the 1940s but not received significant research attention due primarily complexities studying behavior lack any clear definition resistance. In recent years, systematic effort investigate mechanism(s) pest (e.g., German cockroach house fly) have undertaken. Here, we practically define resistance, describe efforts taken by groups elucidate mechanisms, provide insight on designing appropriate bioassays investigating mechanisms future.

Language: Английский

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Lactic acid bacteria modulate the CncC pathway to enhance resistance to β-cypermethrin in the oriental fruit fly

The ISME Journal, Journal Year: 2024, Volume and Issue: 18(1)

Published: Jan. 1, 2024

Abstract The gut microbiota of insects has been shown to regulate host detoxification enzymes. However, the potential regulatory mechanisms involved remain unknown. Here, we report that bacteria increase insecticide resistance by activating cap “n” collar isoform-C (CncC) pathway through enzymatically generated reactive oxygen species (ROS) in Bactrocera dorsalis. We demonstrated Enterococcus casseliflavus and Lactococcus lactis, two lactic acid-producing bacteria, B. dorsalis β-cypermethrin regulating cytochrome P450 (P450) enzymes α-glutathione S-transferase (GST) activities. These symbionts also induced expression CncC muscle aponeurosis fibromatosis. BdCncC knockdown led a decrease caused bacteria. Ingestion ROS scavenger vitamin C resistant strain affected BdCncC/BdKeap1/BdMafK, resulting reduced GST activity. Furthermore, feeding with E. or L. lactis showed BdNOX5 increased production, BdCncC/BdMafK genes. Moreover, acid activated ROS-associated regulation Collectively, our findings indicate symbiotic modulate intestinal pathways affecting physiological biochemistry, thus providing new insights into involvement insect microbes development resistance.

Language: Английский

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Uridine diphosphate glucosyltransferases are involved in spinosad resistance in western flower thrips Frankliniella occidentalis (Pergande)

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 466, P. 133575 - 133575

Published: Jan. 21, 2024

Language: Английский

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The exposure risk of heavy metals to insect pests and their impact on pests occurrence and cross-tolerance to insecticides: A review

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 916, P. 170274 - 170274

Published: Jan. 21, 2024

Language: Английский

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GPCR–MAPK signaling pathways underpin fitness trade-offs in whitefly

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(28)

Published: July 3, 2024

Trade-offs between evolutionary gain and loss are prevalent in nature, yet their genetic basis is not well resolved. The evolution of insect resistance to insecticide often associated with strong fitness costs; however, how the trade-offs operates remains poorly understood. Here, we show that mitogen-activated protein kinase (MAPK) pathway its upstream downstream actors underlie whitefly

Language: Английский

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