Nongenetic inheritance and multigenerational plasticity in the nematode C. elegans DOI Creative Commons
L. Ryan Baugh, Troy Day

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Aug. 25, 2020

A rapidly growing body of literature in several organisms suggests that environmentally-induced adaptive changes phenotype can be transmitted across multiple generations. Although within-generation plasticity has been well documented, multigenerational represents a significant departure from conventional evolutionary thought. Studies C. elegans have particularly influential because this species exhibits extensive phenotypic plasticity, it is often essentially isogenic, and well-documented molecular cellular mechanisms through which nongenetic inheritance occurs. However, while experimentalists are eager to claim modes characterized other model systems enhance fitness, many biologists remain skeptical given the extraordinary nature claim. We establish three criteria evaluate how compelling evidence for is, we use these critically examine putative cases elegans. conclude by suggesting potentially fruitful avenues future research.

Language: Английский

Molecular mechanisms of transgenerational epigenetic inheritance DOI
Maximilian Fitz-James, Giacomo Cavalli

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 23(6), P. 325 - 341

Published: Jan. 4, 2022

Language: Английский

Citations

374
An Integrative Framework for Understanding the Mechanisms and Multigenerational Consequences of Transgenerational Plasticity DOI
Alison M. Bell, Jennifer K. Hellmann

Annual Review of Ecology Evolution and Systematics, Journal Year: 2019, Volume and Issue: 50(1), P. 97 - 118

Published: July 24, 2019

Transgenerational plasticity (TGP) occurs when the environment experienced by a parent influences development of their offspring. In this article, we develop framework for understanding mechanisms and multi-generational consequences TGP. First, conceptualize TGP in context communication between parents (senders) offspring (receivers) dissecting steps an environmental cue received its resulting effects on phenotype one or more future generations. Breaking down problem way highlights diversity likely to be involved process. Second, review literature multigenerational find that documented patterns across generations are diverse. We categorize different explore proximate ultimate can generate them. Throughout, highlight opportunities work dynamic integrative area study.

Language: Английский

Citations

174
Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care DOI Creative Commons
Nicolas J. Pillon, Ruth J. F. Loos, Sally M. Marshall

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(6), P. 1530 - 1544

Published: March 1, 2021

The prevalence of type 2 diabetes and obesity has risen dramatically for decades is expected to rise further, secondary the growing aging, sedentary population. strain on global health care projected be colossal. This review explores latest work emerging ideas related genetic environmental factors influencing metabolism. Translational research clinical applications, including impact COVID-19 pandemic, are highlighted. Looking forward, strategies personalize all aspects prevention, management necessary improve outcomes reduce these metabolic diseases.

Language: Английский

Citations

170
Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice DOI Creative Commons
Yuta Takahashi,

Mariana Morales Valencia,

Yang Yu

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(4), P. 715 - 731.e19

Published: Feb. 1, 2023

Language: Английский

Citations

146
How does epigenetics influence the course of evolution? DOI
Alyson Ashe, Vincent Colot, Benjamin P. Oldroyd

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2021, Volume and Issue: 376(1826), P. 20200111 - 20200111

Published: April 17, 2021

Epigenetics is the study of changes in gene activity that can be transmitted through cell divisions but cannot explained by DNA sequence. Epigenetic mechanisms are central to regulation, phenotypic plasticity, development and preservation genome integrity. often held make a minor contribution evolutionary change because epigenetic states typically erased reset at every generation, therefore, not heritable. Nonetheless, there growing appreciation variation makes direct indirect contributions processes. First, some intergenerationally affect phenotype offspring. Moreover,

Language: Английский

Citations

141
Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency DOI
Bin Chen,

Yarui Du,

Hong Zhu

et al.

Nature, Journal Year: 2022, Volume and Issue: 605(7911), P. 761 - 766

Published: May 18, 2022

Language: Английский

Citations

107
Metabolic memory: mechanisms and diseases DOI Creative Commons
Hao Dong,

Yuezhang Sun,

Lulingxiao Nie

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 28, 2024

Metabolic diseases and their complications impose health economic burdens worldwide. Evidence from past experimental studies clinical trials suggests our body may have the ability to remember metabolic environment, such as hyperglycemia or hyperlipidemia, thus leading chronic inflammatory disorders other even after elimination of these environments. The long-term effects that aberrant metabolism on been summarized memory are found assume a crucial role in states disease. Multiple molecular mechanisms collectively participate management, resulting different cellular alterations well tissue organ dysfunctions, culminating disease progression affecting offspring. elucidation expansion concept provides more comprehensive insight into pathogenic underlying promises be new target detection management. Here, we retrace history relevant research summarize its salient characteristics. We provide detailed discussion by which involved development at molecular, cellular, levels, with emphasis impact epigenetic modulations. Finally, present some pivotal findings arguing favor targeting develop therapeutic strategies for latest reflections consequences implications human diseases.

Language: Английский

Citations

32
tRNA-derived small RNAs in human cancers: roles, mechanisms, and clinical application DOI Creative Commons

Manli Zhou,

Xiaoyun He, Jing Zhang

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 15, 2024

Abstract Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are a new type of non-coding (ncRNAs) produced by the specific cleavage precursor or mature tRNAs. tsRNAs involved in various basic biological processes such as epigenetic, transcriptional, post-transcriptional, and translation regulation, thereby affecting occurrence development human diseases, including cancers. Recent studies have shown that play an important role tumorigenesis regulating behaviors malignant proliferation, invasion metastasis, angiogenesis, immune response, tumor resistance, metabolism reprogramming. These may be potential targets for treatment. Furthermore, can exist abundantly stably bodily fluids (e.g., blood, serum, urine) form free encapsulated extracellular vesicles, intercellular communication microenvironment (TME). Meanwhile, their abnormal expression is closely related to clinicopathological features patients, staging, lymph node poor prognosis patients; thus, served novel liquid biopsy biomarker. This review summarizes discovery, production, analyzes molecular mechanisms applications therapy, which provide strategies early diagnosis targeted therapy tumors.

Language: Английский

Citations

21
Exploring the impact of environmental factors on male reproductive health through epigenetics DOI
Yi Zhang, Jingyan Song, Zhen‐Gao Sun

et al.

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: 132, P. 108832 - 108832

Published: Jan. 6, 2025

Language: Английский

Citations

6
Limitations of cross‐ and multigenerational plasticity for marine invertebrates faced with global climate change DOI Creative Commons
Maria Byrne, Shawna A. Foo, Pauline M. Ross

et al.

Global Change Biology, Journal Year: 2019, Volume and Issue: 26(1), P. 80 - 102

Published: Oct. 31, 2019

Abstract Although cross generation (CGP) and multigenerational (MGP) plasticity have been identified as mechanisms of acclimation to global change, the weight evidence indicates that parental conditioning over generations is not a panacea rescue stress sensitivity in offspring. For many species, there were no benefits conditioning. Even when improved performance was observed, this waned time within or across fitness declined. CGP MGP studies resilient species with tolerant genotypes wild populations selected family lines. Several bivalves possess favourable tolerance phenotypically plastic traits potentially associated genetic adaptation life habitats where they routinely experience temperature and/or acidification stress. These will be important help ‘climate proof’ shellfish ventures. Species are naturally those broad range environmental conditions good candidates provide insights into physiological molecular involved MGP. It challenging conduct ecologically relevant change experiments long times commensurate pace changing climate. As result, present stressors shock‐type exposure at rates much faster than projected scenarios. With more gradual stressor introduction longer experimental durations context currently acclimatized adapted to, outcomes for sensitive might differ. We highlight importance understand primordial germ cell development timing gametogenesis respect exposure. appears limited universal tool face climate, natural proxies future (upwelling zones, CO 2 vents, warm habitats) show phenotypic adjustment beneficial selection possible some indicating complex plasticity–adaptation interactions.

Language: Английский

Citations

134