Abstract
Metabolic
homeostasis
is
under
strict
regulation
of
humoral
factors
across
various
taxa.
In
particular,
insulin
and
glucagon,
referred
to
in
Drosophila
as
insulin‐like
peptides
(DILPs)
adipokinetic
hormone
(AKH),
respectively,
are
key
hormones
that
regulate
metabolism
most
metazoa.
While
much
known
about
the
DILPs,
mechanisms
regulating
AKH/glucagon
production
still
poorly
understood.
this
review,
we
describe
DILPs
AKH
emphasize
need
for
future
studies
decipher
how
energy
governed
.
This
article
categorized
under:
Invertebrate
Organogenesis
>
Flies
Signaling
Pathways
Global
Mechanisms
Abstract
Energy
metabolism
is
a
basic
and
general
process,
by
which
the
body
acquires
uses
energy
to
maintain
normal
function,
taurine
plays
vital
role
in
metabolism.
Taurine
deficiency
may
cause
weak
dysfunction.
biosynthetic
ability
limited,
its
supplementation
diet
can
strengthen
muscle
performance,
cardiac
liver
activity,
adipose
tissue.
Combining
with
other
drugs
have
superior
effect
In
many
metabolic
disorders,
taurine,
or
combination
of
drugs,
also
functions
as
repair
treatment
for
damaged
tissues,
acts
promoter
balance
The
present
study
discusses
potential
roles
PubMed,
Journal Year:
2017,
Volume and Issue:
207(4), P. 1231 - 1253
Published: Dec. 1, 2017
Carbohydrate
metabolism
is
essential
for
cellular
energy
balance
as
well
the
biosynthesis
of
new
building
blocks.
As
animal
nutrient
intake
displays
temporal
fluctuations
and
each
cell
type
within
possesses
specific
metabolic
needs,
elaborate
regulatory
systems
are
needed
to
coordinate
carbohydrate
in
time
space.
regulated
locally
through
gene
networks
signaling
pathways,
which
receive
inputs
from
sensors
other
such
developmental
signals.
Superimposed
on
cell-intrinsic
control,
hormonal
mediates
intertissue
information
maintain
organismal
homeostasis.
Misregulation
causative
many
human
diseases,
diabetes
cancer.
Recent
work
Drosophila
melanogaster
has
uncovered
regulators
introduced
novel
physiological
roles
previously
known
pathways.
Moreover,
genetically
tractable
models
study
metabolism-related
diseases
have
provided
insight
into
mechanisms
pathogenesis.
Due
high
degree
conservation
relevant
vast
possibilities
analysis
gene-nutrient
interactions
tissue-specific
function,
emerging
an
important
model
system
research
metabolism.
Cell,
Journal Year:
2019,
Volume and Issue:
178(4), P. 901 - 918.e16
Published: Aug. 1, 2019
Physiology
and
metabolism
are
often
sexually
dimorphic,
but
the
underlying
mechanisms
remain
incompletely
understood.
Here,
we
use
intestine
of
Drosophila
melanogaster
to
investigate
how
gut-derived
signals
contribute
sex
differences
in
whole-body
physiology.
We
find
that
carbohydrate
handling
is
male-biased
a
specific
portion
intestine.
In
contrast
known
sexual
dimorphisms
invertebrates,
intestinal
extrinsically
controlled
by
adjacent
male
gonad,
which
activates
JAK-STAT
signaling
enterocytes
within
this
portion.
Sex
reversal
experiments
establish
roles
for
metabolic
state
controlling
food
intake
sperm
production
through
citrate.
Our
work
uncovers
gonad-gut
axis
coupling
diet
production,
revealing
communication
across
organs
physiologically
important.
The
instructive
role
citrate
inter-organ
might
be
significant
more
biological
contexts
than
previously
recognized.
Development,
Journal Year:
2018,
Volume and Issue:
145(6)
Published: Feb. 22, 2018
Adapting
to
changes
in
food
availability
is
a
central
challenge
for
survival.
Glucose
an
important
resource
energy
production,
and
therefore
many
organisms
synthesize
retain
sugar
storage
molecules.
In
insects,
glucose
stored
two
different
forms:
the
disaccharide
trehalose
branched
polymer
glycogen.
Glycogen
synthesized
several
tissues,
including
muscle
fat
body.
Despite
major
role
of
body
as
center
metabolism,
importance
its
glycogen
content
remains
unclear.
Here,
we
show
that
metabolism
regulated
tissue-specific
manner
under
starvation
conditions
fruit
fly
Drosophila.
The
mobilization
larvae
independent
Adipokinetic
hormone
(Akh,
glucagon
homolog)
but
by
tissue-autonomous
manner.
Fat
plays
crucial
maintenance
circulating
sugars,
trehalose,
fasting
conditions.
These
results
demonstrate
metabolic
safeguard
