Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity DOI
Susan N. Christo, Maximilien Evrard, Simone L. Park

et al.

Nature Immunology, Journal Year: 2021, Volume and Issue: 22(9), P. 1140 - 1151

Published: Aug. 23, 2021

Language: Английский

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection DOI Creative Commons
Jennifer M. Dan, José Mateus, Yu Kato

et al.

Science, Journal Year: 2021, Volume and Issue: 371(6529)

Published: Jan. 6, 2021

Understanding immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics and vaccines assessing the likely future course of COVID-19 pandemic. We analyzed multiple compartments circulating SARS-CoV-2 in 254 samples from 188 cases, including 43 at ≥6 months after infection. Immunoglobulin G (IgG) spike protein was relatively stable over 6+ months. Spike-specific B cells were more abundant 6 than 1 month symptom onset. SARS-CoV-2-specific CD4

Language: Английский

Citations

2749
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity DOI Creative Commons
Carolyn Rydyznski Moderbacher, Sydney I. Ramirez, Jennifer M. Dan

et al.

Cell, Journal Year: 2020, Volume and Issue: 183(4), P. 996 - 1012.e19

Published: Sept. 16, 2020

Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. We completed a combined examination of all three branches adaptive immunity at level SARS-CoV-2-specific CD4

Language: Английский

Citations

1813
Adaptive immunity to SARS-CoV-2 and COVID-19 DOI Creative Commons
Alessandro Sette, Shane Crotty

Cell, Journal Year: 2021, Volume and Issue: 184(4), P. 861 - 880

Published: Jan. 13, 2021

Language: Английский

Citations

1792
Emerging concepts in the science of vaccine adjuvants DOI Open Access
Bali Pulendran, Prabhu S. Arunachalam,

Derek T. O’Hagan

et al.

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(6), P. 454 - 475

Published: April 6, 2021

Language: Английский

Citations

1000
Cross-tissue immune cell analysis reveals tissue-specific features in humans DOI Creative Commons
Cecilia Domínguez Conde, Chuan Xu, Lorna B. Jarvis

et al.

Science, Journal Year: 2022, Volume and Issue: 376(6594)

Published: May 12, 2022

Despite their crucial role in health and disease, our knowledge of immune cells within human tissues remains limited. We surveyed the compartment 16 from 12 adult donors by single-cell RNA sequencing VDJ generating a dataset ~360,000 cells. To systematically resolve cell heterogeneity across tissues, we developed CellTypist, machine learning tool for rapid precise type annotation. Using this approach, combined with detailed curation, determined tissue distribution finely phenotyped types, revealing hitherto unappreciated tissue-specific features clonal architecture T B Our multitissue approach lays foundation identifying highly resolved types leveraging common reference dataset, tissue-integrated expression analysis, antigen receptor sequencing.

Language: Английский

Citations

589
Prevention of tuberculosis in macaques after intravenous BCG immunization DOI Creative Commons
Patricia A. Darrah, Joseph J. Zeppa, Pauline Maiello

et al.

Nature, Journal Year: 2020, Volume and Issue: 577(7788), P. 95 - 102

Published: Jan. 1, 2020

Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide

Language: Английский

Citations

509
In Vivo CD4+T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm DOI Open Access
Mikel Ruterbusch, Kurt B. Pruner, Laila Shehata

et al.

Annual Review of Immunology, Journal Year: 2020, Volume and Issue: 38(1), P. 705 - 725

Published: April 26, 2020

The discovery of CD4 + T cell subset–defining master transcription factors and framing the Th1/Th2 paradigm ignited field. Advances in vivo experimental systems, however, have revealed that more complex lineage-defining transcriptional networks direct differentiation lymphoid organs tissues. This review focuses on layers fate decisions inform vivo. Cytokine production by antigen-presenting cells other innate influences effector program [e.g., helper type 1 (Th1), Th2, Th17]. Signals downstream receptor influence whether individual clones bearing hallmarks this become follicular cells, supporting development B expressing specific antibody isotypes, or which activate microbicidal These bifurcated, parallel axes allow to augment their particular prevent disease.

Language: Английский

Citations

390
CD8+ T cell metabolism in infection and cancer DOI
Miguel Reina‐Campos, Nicole E. Scharping, Ananda W. Goldrath

et al.

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(11), P. 718 - 738

Published: May 12, 2021

Language: Английский

Citations

390
Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy DOI Creative Commons
Adrienne Luoma, Shengbao Suo, Hannah L. Williams

et al.

Cell, Journal Year: 2020, Volume and Issue: 182(3), P. 655 - 671.e22

Published: June 29, 2020

Language: Английский

Citations

386
High-content CRISPR screening DOI Open Access
Christoph Bock, Paul Datlinger, Florence M. Chardon

et al.

Nature Reviews Methods Primers, Journal Year: 2022, Volume and Issue: 2(1)

Published: Feb. 10, 2022

Language: Английский

Citations

381