Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease – novel insights into cellular communication circuits

Journal of Hepatology, Journal Year: 2022, Volume and Issue: 77(4), P. 1136 - 1160

Published: June 22, 2022

Language: Английский

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Dendritic cell subsets in cancer immunity and tumor antigen sensing

Cellular and Molecular Immunology, Journal Year: 2023, Volume and Issue: 20(5), P. 432 - 447

Published: March 22, 2023

Abstract Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles in both innate adaptive immune responses. Due to their ability cross-present tumor cell-associated antigens naïve T cells, DCs are instrumental the generation of specific T-cell-mediated antitumor effector responses control growth cell dissemination. Within an immunosuppressive microenvironment, DC functions can, however, be severely impaired. In this review, we focus on mechanisms capture activation by role microenvironment shaping functions, taking advantage recent studies showing phenotype acquisition, transcriptional state functional programs revealed scRNA-seq analysis. The therapeutic potential DC-mediated antigen sensing priming immunity is also discussed.

Language: Английский

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Dendritic Cell Regulation of T Helper Cells

Annual Review of Immunology, Journal Year: 2021, Volume and Issue: 39(1), P. 759 - 790

Published: March 12, 2021

As the professional antigen-presenting cells of immune system, dendritic (DCs) sense microenvironment and shape ensuing adaptive response. DCs can induce both activation tolerance according to peripheral cues. Recent work has established that comprise several phenotypically functionally heterogeneous subsets differentially regulate T lymphocyte differentiation. This review summarizes mouse human DC subset phenotypes, development, diversification, function. We focus on advances in our understanding how different distinct CD4+ helper (Th) cell differentiation outcomes, including Th1, Th2, Th17, follicular helper, regulatory cells. intrinsic properties, local tissue microenvironments, other together determine Th during homeostasis inflammation.

Language: Английский

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Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(6), P. 1389 - 1399

Published: June 1, 2023

Language: Английский

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ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut

Nature, Journal Year: 2022, Volume and Issue: 610(7933), P. 744 - 751

Published: Sept. 7, 2022

Language: Английский

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Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes

Nature, Journal Year: 2022, Volume and Issue: 606(7915), P. 776 - 784

Published: May 25, 2022

Language: Английский

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CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours

Nature, Journal Year: 2023, Volume and Issue: 618(7967), P. 1033 - 1040

Published: June 14, 2023

Most clinically applied cancer immunotherapies rely on the ability of CD8

Language: Английский

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XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Nature Medicine, Journal Year: 2021, Volume and Issue: 27(6), P. 1043 - 1054

Published: May 20, 2021

Language: Английский

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Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(11), P. 739 - 754

Published: Aug. 16, 2023

Language: Английский

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SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity

Nature, Journal Year: 2023, Volume and Issue: 620(7972), P. 200 - 208

Published: July 5, 2023

Abstract Cancer cells evade T cell-mediated killing through tumour–immune interactions whose mechanisms are not well understood 1,2 . Dendritic (DCs), especially type-1 conventional DCs (cDC1s), mediate cell priming and therapeutic efficacy against tumours 3 DC functions orchestrated by pattern recognition receptors 3–5 , although other signals involved remain incompletely defined. Nutrients emerging mediators of adaptive immunity 6–8 but whether nutrients affect function or communication between innate immune is largely unresolved. Here we establish glutamine as an intercellular metabolic checkpoint that dictates tumour–cDC1 crosstalk licenses cDC1 in activating cytotoxic cells. Intratumoral supplementation inhibits tumour growth augmenting cDC1-mediated CD8 + immunity, overcomes resistance to blockade immunotherapies. Mechanistically, cDC1s compete for uptake via the transporter SLC38A2 tune anti-tumour immunity. Nutrient screening integrative analyses show dominant amino acid promoting function. Further, signalling FLCN impinges on TFEB Loss selectively impairs vivo a TFEB-dependent manner phenocopies deficiency eliminating effect supplementation. Our findings glutamine-mediated underpins evasion, reveal acquisition limiting events activation putative targets cancer treatment.

Language: Английский

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