Architecture of the dynamic fungal cell wall

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 21(4), P. 248 - 259

Published: Oct. 20, 2022

Language: Английский

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Immune responses to human fungal pathogens and therapeutic prospects

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(7), P. 433 - 452

Published: Jan. 4, 2023

Language: Английский

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Neutrophil extracellular traps in homeostasis and disease

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 20, 2024

Language: Английский

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Candida albicans and Candida glabrata : global priority pathogens

Microbiology and Molecular Biology Reviews, Journal Year: 2024, Volume and Issue: 88(2)

Published: June 4, 2024

SUMMARYA significant increase in the incidence of

Language: Английский

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Immunity to fungi in the lung

Seminars in Immunology, Journal Year: 2023, Volume and Issue: 66, P. 101728 - 101728

Published: Feb. 24, 2023

Language: Английский

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Glutathione-mediated redox regulation in Cryptococcus neoformans impacts virulence

Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(8), P. 2084 - 2098

Published: July 2, 2024

Language: Английский

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Candida albicans and Antifungal Peptides

Infectious Diseases and Therapy, Journal Year: 2023, Volume and Issue: 12(12), P. 2631 - 2648

Published: Nov. 8, 2023

Candida albicans, a ubiquitous opportunistic fungal pathogen, plays pivotal role in human health and disease. As commensal organism, it normally resides harmlessly within the microbiota. However, under certain conditions, C. albicans can transition into pathogenic state, leading to various infections collectively known as candidiasis. With increasing prevalence of immunocompromised individuals widespread use invasive medical procedures, candidiasis has become significant public concern. The emergence drug-resistant strains further complicates treatment options, highlighting urgent need for alternative therapeutic strategies. Antifungal peptides (AFPs) have gained considerable attention potential candidates combating spp. infections. These naturally occurring possess broad-spectrum antimicrobial activity, including specific efficacy against albicans. AFPs exhibit several advantageous properties, such rapid killing kinetics, low propensity resistance development, diverse mechanisms action, making them promising alternatives conventional antifungal agents. In recent years, extensive research focused on discovering developing novel with improved selectivity species. Advances biotechnology synthetic peptide design enabled modification optimization natural peptides, enhancing their stability, bioavailability, potential. Nevertheless, challenges must be addressed before widely implemented clinical practice. include optimizing delivery methods, overcoming toxicity concerns, conducting comprehensive preclinical studies. This commentary presents short overview candidemia AFP; articles reviews published last 10 years were searched National Library Medicine (National Center Biotechnology Information–NIH–PubMed). terms used infections, treatments guidelines, challenges, trials main ones. Older publications cited if they brought some relevant concept or helped bring perspective our narrative. Articles older than 20 those that appeared PubMed but did not match goal updated information about using an considered.

Language: Английский

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Wake-up Call: Rapid Increase in Human Fungal Diseases under Climate Change

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(4)

Published: April 1, 2024

Rising temperatures and extreme weather are setting the stage for increases in fungal diseases. As new pathogenic fungi emerge known threats spread evolve, scientists decision makers responding.

Language: Английский

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Marine-Derived Metabolites Act as Promising Antifungal Agents

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(4), P. 180 - 180

Published: April 17, 2024

The incidence of invasive fungal diseases (IFDs) is on the rise globally, particularly among immunocompromised patients, leading to significant morbidity and mortality. Current clinical antifungal agents, such as polyenes, azoles, echinocandins, face increasing resistance from pathogenic fungi. Therefore, there a pressing need for development novel drugs. Marine-derived secondary metabolites represent valuable resources that are characterized by varied chemical structures pharmacological activities. While numerous compounds exhibiting promising activity have been identified, comprehensive review elucidating their specific underlying mechanisms remains lacking. In this review, we compiled summary derived marine organisms, highlighting diverse action targeting various cellular components, including cell wall, membrane, mitochondria, chromosomes, drug efflux pumps, several biological processes, vesicular trafficking growth hyphae biofilms. This helpful subsequent drugs due its organisms.

Language: Английский

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The microbial damage and host response framework: lesson learned from pathogenic survival trajectories and immunoinflammatory responses of Talaromyces marneffei infection

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 12, 2024

The adverse outcomes of fungal infection in mammalian hosts depend on the complex interactions between host immune system and pathogen virulence-associated traits. main clinical problems arise when response is either too weak to effectively eliminate or overly aggressive, resulting tissue damage rather than protection. This article will highlight current knowledge regarding virulence attributions mechanisms involved dual-sided role immunopathogenesis thermally dimorphic fungus Talaromyces marneffei through lens framework (DRF) microbial pathogenesis model.

Language: Английский

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