The Impact of Fermented Milk Products Containing Bifidobacterium longum BB536 on the Gut Environment: A Randomized Double-Blind Placebo-Controlled Trial DOI Open Access
Ryuta Ejima, Riko Mishima,

Akira Sen

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3580 - 3580

Published: Oct. 22, 2024

Probiotics, particularly those native to the gut microbiota, have a profound influence on environment. In this study, we conducted randomized placebo-controlled, double-blind, parallel-group comparison trial investigate effects of Bifidobacterium longum BB536 (B. BB536) fecal microbiota and metabolite compositions in healthy individuals. We compared fermented milk produced solely with Streptococcus thermophiles Lactobacillus bulgaricus (placebo group) supplemented B. (BY group). Our findings revealed significantly greater relative abundance Faecalibacterium BY group than placebo by 3rd day, trend that persisted until end 17th day. Additionally, presented increased concentrations tryptophan (Trp), Indole-3-lactic acid, Indole-3-aldehyde A significant positive correlation was observed between number viable bacteria feces. The Trp Indole-3-acetic acid were also correlated results suggest intake can modulate profiles, which are general indicators for monitoring environment, potentially conferring health benefits host.

Language: Английский

The gills and skin microbiota of five pelagic fish species from the Atlantic Ocean DOI Creative Commons
José Luis Varela, Eleni Nikouli, Antonio Medina

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 25, 2024

Abstract The gills and skin microbiota microbiome of wild fish remain far more under-investigated compared to that farmed species, despite these animal-microbe interactions hold the same ecophysiological roles in both cases. In this study, bacterial profiles their presumptive metabolisms were investigated five open-sea fishes: bullet tuna ( Auxis sp.), common dolphinfish Coryphaena hippurus ), Atlantic little tunny Euthynnus alletteratus bonito Sarda sarda ) white marlin Tetrapturus albidus ). Gills tissues collected from two three individuals per specimens caught by recreational trolling during summer 2019 16S rRNA gene diversity was analysed high-throughput sequencing. communities among species clearly different but not microbiota. dominant operational taxonomic units beloged Moraxellaceae, Pseudomonadaceae, Rhodobacteraceae, Staphylococcaceae Vibrionaceae families. Despite differences composition, between fishes here ≥ 94% dominated basic metabolism, most likely reflecting continuous exposure surrounding seawater.

Language: Английский

Citations

0
Gubra Amylin‐NASH Diet Induced Nonalcoholic Fatty Liver Disease Associated with Histological Damage, Oxidative Stress, Immune Disorders, Gut Microbiota, and Its Metabolic Dysbiosis in Colon DOI
Zhimin Zhang, Xinyi Qin, Yi Tao

et al.

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(15)

Published: July 5, 2024

The overall changes of colon under nonalcoholic fatty liver disease (NAFLD) remain to be further elucidated.

Language: Английский

Citations

0
The effect of microbial metabolites from colonic protein fermentation on bacteria-induced cytokine production in dendritic cells DOI
Zhuqing Xie,

Danny Blichfeldt Eriksen,

Peter Riber Johnsen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 17, 2024

Abstract Scope Compared to the well-defined immune-modulating effect of butyrate, knowledge other metabolites from colonic protein fermentation is limited. Methods and results The protein-derived (valerate, branched-chain fatty acids, ammonium, phenol, p-Cresol, indole, H 2 S) on cytokine production in murine bone marrow-derived dendritic cells (BMDCs) stimulated with LPS, Lactobacillus acidophilus NCFM, or Staphylococcus aureus USA300 was investigated. modulated profile differently depended specific microbial stimulus short-chain acids (SCFAs) exhibiting strongest effects no toxicity. After short-term treatment, SCFAs affected similar but weaker than reflected by inhibition IL-12p70 IL-10 enhanced IL-23 (LPS S. USA300) IL-1β production. valerate, butyrate exhibited a stronger more prompt gene expression without influencing reactive oxygen species (ROS) formation. Oppositely, long-term treatment two resulted anti-inflammatory effects, i.e. abrogation LPS-induced IL-12 enhancement aryl hydrocarbon receptor ( Ahr ) LPS-stimulated dual specificity phosphatase 1 Dusp1 ). Conclusion Our data reveals various metabolites, valerate holds activities resembling not identical butyrate.

Language: Английский

Citations

0
Tailored impact of dietary fibers on gut microbiota: a multi-omics comparison on the lean and obese microbial communities DOI Creative Commons
Andrea Dell’Olio, William T. Scott,

Silvia Taroncher-Ferrer

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

Abstract Background: Previous studies have shown that microbial communities differ in obese and lean individuals, dietary fiber can help reduce obesity-related conditions through diet-gut microbiota interactions. However, the mechanisms by which fibers shape gut still need to be elucidated. In this vitro study, we examined how apple affect on a global scale. We employed high-throughput micro-matrix bioreactor system multi-omics approach identify key microorganisms metabolites involved process. Results: Initially, metagenomics metabolomics data indicated had distinct starting communities. found different characteristics, including higher levels of Ruminococcus bromii lower Faecalibacterium prausnitzii, along with an increased Firmicutes:Bacteroides ratio. Afterward, exposed as representative complex food matrix, pectin soluble fiber, cellulose insoluble fiber. Dietary fibers, particularly pectin, reduced Acidaminococcus intestini boosted Megasphaera Akkermansia community. Additionally, these altered production metabolites, increasing beneficial indole metabolites. Our results underscored ability microbiota. Conclusion: branched-chain amino acid catabolism hexanoic production, potentially impacting energy balance. Apple especially influenced community, altering both species Notably, feeding condition affected like Klebsiella pneumoniae Bifidobacteriumlongum. By using genome-scale metabolic modeling, discovered mutualistic cross-feeding relationship between sp. MJR8396C Bifidobacterium adolescentis. This study suggests incorporating into diets individuals modify composition bacteria improve health. personalized could mitigate effects obesity.

Language: Английский

Citations

0
The Impact of Fermented Milk Products Containing Bifidobacterium longum BB536 on the Gut Environment: A Randomized Double-Blind Placebo-Controlled Trial DOI Open Access
Ryuta Ejima, Riko Mishima,

Akira Sen

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3580 - 3580

Published: Oct. 22, 2024

Probiotics, particularly those native to the gut microbiota, have a profound influence on environment. In this study, we conducted randomized placebo-controlled, double-blind, parallel-group comparison trial investigate effects of Bifidobacterium longum BB536 (B. BB536) fecal microbiota and metabolite compositions in healthy individuals. We compared fermented milk produced solely with Streptococcus thermophiles Lactobacillus bulgaricus (placebo group) supplemented B. (BY group). Our findings revealed significantly greater relative abundance Faecalibacterium BY group than placebo by 3rd day, trend that persisted until end 17th day. Additionally, presented increased concentrations tryptophan (Trp), Indole-3-lactic acid, Indole-3-aldehyde A significant positive correlation was observed between number viable bacteria feces. The Trp Indole-3-acetic acid were also correlated results suggest intake can modulate profiles, which are general indicators for monitoring environment, potentially conferring health benefits host.

Language: Английский

Citations

0