Orchestrating Opiate-Associated Memories in Thalamic Circuits

Neuron, Journal Year: 2020, Volume and Issue: 107(6), P. 1113 - 1123.e4

Published: July 16, 2020

Language: Английский

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Impact of Early Life Stress on Reward Circuit Function and Regulation

Frontiers in Psychiatry, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 20, 2021

Early life stress – including experience of child maltreatment, neglect, separation from or loss a parent, and other forms adversity increases lifetime risk mood, anxiety, substance use disorders. A major component this may be early stress-induced alterations in motivation reward processing, mediated by changes the nucleus accumbens (NAc) ventral tegmental area (VTA). Here, we review evidence impact on circuit structure function human animal models, with focus NAc. We then connect these results to emerging theoretical models about indirect direct impacts development. Through synthesis, aim highlight open research questions suggest avenues future study service basic science, as well applied insights. Understanding how alters development, function, motivated behaviors is critical first step toward developing ability predict, prevent, treat stress-related psychopathology spanning

Language: Английский

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The Raphe Dopamine System Controls the Expression of Incentive Memory

Neuron, Journal Year: 2020, Volume and Issue: 106(3), P. 498 - 514.e8

Published: March 6, 2020

Language: Английский

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Compulsive drug use is associated with imbalance of orbitofrontal- and prelimbic-striatal circuits in punishment-resistant individuals

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(18), P. 9066 - 9071

Published: April 15, 2019

Significance Addiction is characterized by compulsive drug use despite negative consequences. In a rat model of methamphetamine self-administration, we found that compulsive-like taking was correlated with alterations in the balance between an increased orbitofrontal cortex-dorsomedial striatal “go” circuit and decreased prelimbic cortex-ventrolateral “stop” only addictive-like subgroup resistant to foot shock punishment paired taking. nonaddictive-like rats, go-stop balance, which similarly changed after repeated self-administration without punishment, normalized toward baseline levels punishment. These results indicate restoring physiological perhaps noninvasive brain stimulation, may provide promising avenue for addiction treatment when coupled neuroimaging assess clinical responses determine adequacy course treatment.

Language: Английский

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In vivo functional diversity of midbrain dopamine neurons within identified axonal projections

eLife, Journal Year: 2019, Volume and Issue: 8

Published: Oct. 3, 2019

Functional diversity of midbrain dopamine (DA) neurons ranges across multiple scales, from differences in intrinsic properties and connectivity to selective task engagement behaving animals. Distinct vitro biophysical features DA have been associated with different axonal projection targets. However, it is unknown how this translates firing patterns projection-defined subpopulations the intact brain. We combined retrograde tracing single-unit recording labelling mouse brain create an vivo functional topography system. identified burst among projecting dorsolateral striatum. Bursting also differentiated medial substantia nigra (SN) either dorsal or ventral found mean rates pause durations tegmental area (VTA) lateral shell nucleus accumbens. Our data establishes a high-resolution landscape neurons.

Language: Английский

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