Two-photon imaging in mice shows striosomes and matrix have overlapping but differential reinforcement-related responses DOI Creative Commons

Bernard Bloem,

Rafiq Huda, Mriganka Sur

et al.

eLife, Journal Year: 2017, Volume and Issue: 6

Published: Dec. 18, 2017

Striosomes were discovered several decades ago as neurochemically identified zones in the striatum, yet technical hurdles have hampered study of functions these striatal compartments. Here we used 2-photon calcium imaging neuronal birthdate-labeled Mash1-CreER;Ai14 mice to image simultaneously activity striosomal and matrix neurons performed an auditory conditioning task. With this method, circumscribed tdTomato-labeled neuropil that correspond striosomes verified immunohistochemically. Neurons both responded reward-predicting cues active during or after consummatory licking. However, found quantitative differences response strength: fired more encoded information about expected outcome learned task, whereas strongly modulated by recent reward history. These findings open possibility harnessing vivo determine contributions circuit function.

Language: Английский

The mouse cortico-striatal projectome DOI
Houri Hintiryan, Nicholas N. Foster, Ian Bowman

et al.

Nature Neuroscience, Journal Year: 2016, Volume and Issue: 19(8), P. 1100 - 1114

Published: June 20, 2016

Language: Английский

Citations

523
Striatal circuits for reward learning and decision-making DOI
Julia Cox, Ilana B. Witten

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(8), P. 482 - 494

Published: June 6, 2019

Language: Английский

Citations

486
A competitive inhibitory circuit for selection of active and passive fear responses DOI
Jonathan P. Fadok, Sabine Krabbe, Milica Marković

et al.

Nature, Journal Year: 2017, Volume and Issue: 542(7639), P. 96 - 100

Published: Jan. 25, 2017

Language: Английский

Citations

469
Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq DOI Creative Commons
Özgün Gökçe, Geoff Stanley, Barbara Treutlein

et al.

Cell Reports, Journal Year: 2016, Volume and Issue: 16(4), P. 1126 - 1137

Published: July 1, 2016

The striatum contributes to many cognitive processes and disorders, but its cell types are incompletely characterized. We show that microfluidic FACS-based single-cell RNA sequencing of mouse provides a well-resolved classification striatal type diversity. Transcriptome analysis revealed ten differentiated, distinct types, including neurons, astrocytes, oligodendrocytes, ependymal, immune, vascular cells, enabled the discovery numerous marker genes. Furthermore, we identified two discrete subtypes medium spiny neurons (MSNs) have specific markers overexpress genes linked disorders addiction. also describe continuous cellular identities, which increase heterogeneity within types. Finally, type-specific transcription splicing factors shape identities by regulating expression patterns. Our findings suggest functional diversity complex tissue arises from small number can exist in spectrum states.

Language: Английский

Citations

413
Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia DOI Creative Commons
Lindsay M. De Biase,

Kornel E. Schuebel,

Zachary Fusfeld

et al.

Neuron, Journal Year: 2017, Volume and Issue: 95(2), P. 341 - 356.e6

Published: July 1, 2017

Language: Английский

Citations

374
Neural mechanisms of mother–infant bonding and pair bonding: Similarities, differences, and broader implications DOI

Michael Numan,

Larry J. Young

Hormones and Behavior, Journal Year: 2015, Volume and Issue: 77, P. 98 - 112

Published: June 7, 2015

Language: Английский

Citations

330
A basal ganglia circuit for evaluating action outcomes DOI
Marcus Stephenson‐Jones, Kai Yu, Sandra Ahrens

et al.

Nature, Journal Year: 2016, Volume and Issue: 539(7628), P. 289 - 293

Published: Sept. 20, 2016

Language: Английский

Citations

217
Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia DOI Creative Commons
Michael L. Wallace, Arpiar Saunders, Kee Wui Huang

et al.

Neuron, Journal Year: 2017, Volume and Issue: 94(1), P. 138 - 152.e5

Published: April 1, 2017

Language: Английский

Citations

204
Distinct Cortical-Thalamic-Striatal Circuits through the Parafascicular Nucleus DOI Creative Commons

Gil Mandelbaum,

Julián Taranda,

Trevor M. Haynes

et al.

Neuron, Journal Year: 2019, Volume and Issue: 102(3), P. 636 - 652.e7

Published: March 21, 2019

Language: Английский

Citations

159
New Avenues for the Treatment of Huntington’s Disease DOI Open Access
Amy Kim,

Kathryn M. Lalonde,

Aaron Truesdell

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(16), P. 8363 - 8363

Published: Aug. 4, 2021

Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG expansion in the HD gene. The characterized neurodegeneration, particularly striatum and cortex. first symptoms usually appear mid-life include cognitive deficits motor disturbances that progress over time. Despite being genetic with known cause, several mechanisms are thought to contribute neurodegeneration HD, numerous pre-clinical clinical studies have been conducted currently underway test efficacy of therapeutic approaches targeting some these varying degrees success. Although current trials may lead identification or refinement treatments likely improve quality life those living major efforts continue be invested at level, testing novel show promise as disease-modifying strategies. This review offers detailed overview approved treatment options for this concludes discussing potential shown studies, including increasing neurotropic support, modulating autophagy, epigenetic manipulations, use nanocarriers stem cells.

Language: Английский

Citations

141