Nutrients,
Journal Year:
2022,
Volume and Issue:
14(22), P. 4932 - 4932
Published: Nov. 21, 2022
The
ketone
bodies
(KBs)
β-hydroxybutyrate
and
acetoacetate
are
important
alternative
energy
sources
for
glucose
during
nutrient
deprivation.
KBs
synthesized
by
hepatic
ketogenesis
catabolized
to
acetyl-CoA
through
ketolysis
in
extrahepatic
tissues,
followed
the
tricarboxylic
acid
cycle
electron
transport
chain
ATP
production.
Ketogenesis
regulated
key
rate-limiting
enzymes,
3-hydroxy-3-methylglutaryl-CoA
synthase
2
succinyl-CoA:3-oxoacid-CoA
transferase,
respectively.
participate
various
cellular
processes
as
signaling
molecules.
bind
G
protein-coupled
receptors.
most
abundant
KB,
β-hydroxybutyrate,
regulates
gene
expression
other
functions
inducing
post-translational
modifications.
protect
tissues
regulating
inflammation
oxidative
stress.
Recently,
interest
has
been
increasing
due
their
potential
treatment
of
diseases
such
neurological
cardiovascular
cancer.
Cancer
cells
reprogram
metabolism
maintain
rapid
cell
growth
proliferation.
Dysregulation
KB
also
plays
a
role
tumorigenesis
types
Targeting
metabolic
changes
dietary
interventions,
including
fasting
ketogenic
diets,
shown
beneficial
effects
cancer
therapy.
Here,
we
review
current
knowledge
molecular
mechanisms
involved
regulation
functions,
therapeutic
diets
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: May 13, 2023
Abstract
In
the
past
period,
due
to
rapid
development
of
next-generation
sequencing
technology,
accumulating
evidence
has
clarified
complex
role
human
microbiota
in
cancer
and
therapeutic
response.
More
importantly,
available
seems
indicate
that
modulating
composition
gut
improve
efficacy
anti-cancer
drugs
may
be
feasible.
However,
intricate
complexities
exist,
a
deep
comprehensive
understanding
how
interacts
with
is
critical
realize
its
full
potential
treatment.
The
purpose
this
review
summarize
initial
clues
on
molecular
mechanisms
regarding
mutual
effects
between
development,
highlight
relationship
microbes
immunotherapy,
chemotherapy,
radiation
therapy
surgery,
which
provide
insights
into
formulation
individualized
strategies
for
management.
addition,
current
emerging
microbial
interventions
as
well
their
clinical
applications
are
summarized.
Although
many
challenges
remain
now,
great
importance
cannot
overstated
strategies,
it
necessary
explore
holistic
approach
incorporates
modulation
cancer.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: July 23, 2022
Nutriments
have
been
deemed
to
impact
all
physiopathologic
processes.
Recent
evidences
in
molecular
medicine
and
clinical
trials
demonstrated
that
adequate
nutrition
treatments
are
the
golden
criterion
for
extending
healthspan
delaying
ageing
various
species
such
as
yeast,
drosophila,
rodent,
primate
human.
It
emerges
develop
precision-nutrition
therapeutics
slow
age-related
biological
processes
treat
diverse
diseases.
However,
nutritive
advantages
frequently
diversify
among
individuals
well
organs
tissues,
which
brings
challenges
this
field.
In
review,
we
summarize
different
forms
of
dietary
interventions
extensively
prescribed
improvement
disease
treatment
pre-clinical
or
clinical.
We
discuss
nutrient-mediated
mechanisms
including
metabolic
regulators,
metabolism
pathways,
epigenetic
circadian
clocks.
Comparably,
describe
diet-responsive
effectors
by
influence
endocrinic,
immunological,
microbial
neural
states
responsible
improving
health
preventing
multiple
diseases
humans.
Furthermore,
expatiate
patterns
dietotheroapies,
fasting,
calorie-restricted
diet,
ketogenic
high-fibre
plants-based
protein
restriction
diet
with
specific
reduction
amino
acids
microelements,
potentially
affecting
morbid
states.
Altogether,
emphasize
profound
nutritional
therapy,
highlight
crosstalk
explored
critical
factors
individualized
therapeutic
approaches
predictors.
Annual Review of Pathology Mechanisms of Disease,
Journal Year:
2022,
Volume and Issue:
18(1), P. 467 - 492
Published: Nov. 2, 2022
Reprogrammed
metabolism
is
a
hallmark
of
colorectal
cancer
(CRC).
CRC
cells
are
geared
toward
rapid
proliferation,
requiring
nutrients
and
the
removal
cellular
waste
in
nutrient-poor
environments.
Intestinal
stem
(ISCs),
primary
cell
origin
for
CRCs,
must
adapt
their
along
adenoma-carcinoma
sequence
to
unique
features
complex
microenvironment
that
include
interactions
with
intestinal
epithelial
cells,
immune
stromal
commensal
microbes,
dietary
components.
Emerging
evidence
implicates
modifiable
risk
factors
related
environment,
such
as
diet,
important
pathogenesis.
Here,
we
focus
on
describing
ISCs,
diets
influence
initiation,
genetics
metabolism,
tumor
microenvironment.
The
mechanistic
links
between
environmental
factors,
metabolic
adaptations,
enhancing
or
supporting
tumorigenesis
becoming
better
understood.
Thus,
greater
knowledge
holds
promise
improved
prevention
treatment.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Dec. 29, 2022
Metabolic
reprogramming
is
involved
in
the
pathogenesis
of
not
only
cancers
but
also
neurodegenerative
diseases,
cardiovascular
and
infectious
diseases.
With
progress
metabonomics
proteomics,
metabolites
have
been
found
to
affect
protein
acylations
through
providing
acyl
groups
or
changing
activities
acyltransferases
deacylases.
Reciprocally,
acylation
key
cellular
processes
relevant
physiology
such
as
stability,
subcellular
localization,
enzyme
activity,
transcriptional
protein-protein
interactions
protein-DNA
interactions.
Herein,
we
summarize
functional
diversity
mechanisms
eight
kinds
nonhistone
physiological
progression
several
We
highlight
recent
development
inhibitors
for
acyltransferase,
deacylase,
reader
proteins
their
potential
applications
drug
discovery.
Circulation Research,
Journal Year:
2023,
Volume and Issue:
132(7), P. 882 - 898
Published: March 30, 2023
The
ketone
bodies
beta-hydroxybutyrate
and
acetoacetate
are
hepatically
produced
metabolites
catabolized
in
extrahepatic
organs.
Ketone
a
critical
cardiac
fuel
have
diverse
roles
the
regulation
of
cellular
processes
such
as
metabolism,
inflammation,
crosstalk
multiple
organs
that
mediate
disease.
This
review
focuses
on
role
metabolism
health
disease
with
an
emphasis
therapeutic
potential
ketosis
treatment
for
heart
failure
(HF).
Cardiac
metabolic
reprogramming,
characterized
by
diminished
mitochondrial
oxidative
contributes
to
dysfunction
pathologic
remodeling
during
development
HF.
Growing
evidence
supports
adaptive
HF
promote
normal
function
attenuate
progression.
Enhanced
utilization
is
mediated
increased
availability
due
systemic
autonomous
upregulation
ketolytic
enzymes.
Therapeutic
strategies
designed
restore
high-capacity
show
promise
address
deficits
underpin
progression
However,
mechanisms
involved
beneficial
effects
yet
be
defined
represent
important
future
lines
inquiry.
In
addition
use
energy
substrate
oxidation,
modulate
myocardial
glucose
fatty
acids,
two
vital
substrates
regulate
hypertrophy.
salutary
may
also
include
extra-cardiac
modulating
immune
responses,
reducing
fibrosis,
promoting
angiogenesis
vasodilation.
Additional
pleotropic
signaling
properties
AcAc
discussed
including
epigenetic
protection
against
stress.
Evidence
benefit
feasibility
examined
preclinical
clinical
studies.
Finally,
ongoing
trials
reviewed
perspective
translation
therapeutics
