Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: July 4, 2024
In
this
study,
We
aim
to
explore
the
association
between
neutrophil
lymphocyte
ratio
(NLR),
platelet
(PLR),
systemic
immune-inflammatory
index
(SII),
monocyte
(LMR)
and
prognostic
nutritional
(PNI)
distant
metastasis
of
gastric
cancer
develop
an
efficient
nomogram
for
screening
patients
with
metastasis.
A
total
1281
inpatients
were
enrolled
divided
into
training
validation
set.Univariate,
Lasso
regression
Multivariate
Logistic
Regression
Analysis
was
used
identify
risk
factors
The
independent
predictive
then
in
model.
nomogram's
perform
clinical
practicality
evaluated
by
receiver
operating
characteristics
(ROC)
curves,
calibration
curves
decision
curve
analysis.
identified
D-dimer,
CA199,
CA125,
NLR
PNI
as
factors.
area
under
our
based
on
these
0.838
cohort
0.811
cohort.
plots
demonstrated
good
performance
both
Therefore,our
could
be
important
tool
clinicians
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 29, 2024
Background
The
inflammatory
response
plays
an
essential
role
in
the
tumor
microenvironment
(TME)
of
colorectal
cancer
(CRC)
by
modulating
growth,
progression,
and
to
therapy
through
recruitment
immune
cells,
production
cytokines,
activation
signaling
pathways.
However,
molecular
subtypes
risk
score
prognostic
model
based
on
remain
be
further
explored.
Methods
Inflammation-related
genes
were
collected
from
signature
database
identified
using
nonnegative
matrix
factorization
TCGA
cohort.
We
compared
clinicopathological
features,
infiltration,
somatic
mutation
profile,
survival
prognosis,
drug
sensitivity
between
subtypes.
was
developed
LASSO
multivariate
Cox
regression
above
results
independently
validated
GEO
Moreover,
we
explored
biological
functions
hub
gene,
receptor
interacting
protein
kinase
2
(RIPK2),
leveraging
proteomics
data,
vivo
,
vitro
experiments.
Results
two
inflammation-related
(inflammation-low
inflammation-high)
have
excellent
internal
consistency
stability.
Inflammation-high
subtype
showed
higher
cell
infiltration
increased
common
chemotherapeutic
drugs,
while
inflammation-low
may
more
suitable
for
immunotherapy.
Besides,
differ
significantly
pathway
enrichment
functions.
In
addition,
11-gene
constructed
strong
assessment
power
could
serve
as
a
novel
marker
predict
CRC
patients.
Finally,
RIPK2
crucial
promoting
malignant
proliferation
experiment.
Conclusions
This
study
provides
new
insights
into
heterogeneity
opportunities
treatment
development
clinical
decision
making.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: July 4, 2024
In
this
study,
We
aim
to
explore
the
association
between
neutrophil
lymphocyte
ratio
(NLR),
platelet
(PLR),
systemic
immune-inflammatory
index
(SII),
monocyte
(LMR)
and
prognostic
nutritional
(PNI)
distant
metastasis
of
gastric
cancer
develop
an
efficient
nomogram
for
screening
patients
with
metastasis.
A
total
1281
inpatients
were
enrolled
divided
into
training
validation
set.Univariate,
Lasso
regression
Multivariate
Logistic
Regression
Analysis
was
used
identify
risk
factors
The
independent
predictive
then
in
model.
nomogram's
perform
clinical
practicality
evaluated
by
receiver
operating
characteristics
(ROC)
curves,
calibration
curves
decision
curve
analysis.
identified
D-dimer,
CA199,
CA125,
NLR
PNI
as
factors.
area
under
our
based
on
these
0.838
cohort
0.811
cohort.
plots
demonstrated
good
performance
both
Therefore,our
could
be
important
tool
clinicians
