Cell Proliferation,
Journal Year:
2023,
Volume and Issue:
56(6)
Published: Feb. 19, 2023
Epithelial-mesenchymal
transition
(EMT)
or
mesenchymal-epithelial
(MET)
plays
critical
roles
in
cancer
metastasis.
Recent
studies,
especially
those
based
on
single-cell
sequencing,
have
revealed
that
EMT
is
not
a
binary
process,
but
heterogeneous
and
dynamic
disposition
with
intermediary
partial
states.
Multiple
double-negative
feedback
loops
involved
by
EMT-related
transcription
factors
(EMT-TFs)
been
identified.
These
between
drivers
MET
finely
regulate
the
state
of
cell.
In
this
review,
general
characteristics,
biomarkers
molecular
mechanisms
different
states
were
summarized.
We
additionally
discussed
direct
indirect
tumour
More
importantly,
article
provides
evidence
heterogeneity
closely
related
to
poor
prognosis
gastric
cancer.
Notably,
seesaw
model
was
proposed
explain
how
cells
themselves
remain
specific
states,
including
epithelial
state,
hybrid/intermediate
mesenchymal
state.
Additionally,
also
review
current
status,
limitations
future
perspectives
signalling
clinical
applications.
Genes & Development,
Journal Year:
2018,
Volume and Issue:
32(17-18), P. 1105 - 1140
Published: Sept. 1, 2018
Despite
the
high
long-term
survival
in
localized
prostate
cancer,
metastatic
cancer
remains
largely
incurable
even
after
intensive
multimodal
therapy.
The
lethality
of
advanced
disease
is
driven
by
lack
therapeutic
regimens
capable
generating
durable
responses
setting
extreme
tumor
heterogeneity
on
genetic
and
cell
biological
levels.
Here,
we
review
available
model
systems,
genome
atlas,
cellular
functional
microenvironment,
tumor-intrinsic
tumor-extrinsic
mechanisms
underlying
resistance,
technological
advances
focused
detection
management.
These
advances,
along
with
an
improved
understanding
adaptive
to
conventional
therapies,
anti-androgen
therapy,
immunotherapy,
are
catalyzing
development
more
effective
strategies
for
disease.
In
particular,
knowledge
heterotypic
interactions
between
coevolution
host
cells
microenvironment
has
illuminated
novel
combinations
a
strong
potential
eventual
cures
Improved
management
will
also
benefit
from
artificial
intelligence-based
expert
decision
support
systems
proper
standard
care,
prognostic
determinant
biomarkers
minimize
overtreatment
disease,
new
standards
care
accelerated
next-generation
clinical
trials.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: Nov. 22, 2021
Abstract
Circulating
tumor
cells
(CTCs)
are
that
have
sloughed
off
the
primary
and
extravasate
into
circulate
in
blood.
Understanding
of
metastatic
cascade
CTCs
has
tremendous
potential
for
identification
targets
against
cancer
metastasis.
Detecting
these
very
rare
among
massive
blood
is
challenging.
However,
emerging
technologies
detection
profoundly
contributed
to
deepening
investigation
biology
facilitated
their
clinical
application.
Current
summarized
herein,
together
with
advantages
disadvantages.
The
usually
dependent
on
molecular
markers,
epithelial
cell
adhesion
molecule
being
most
widely
used,
although
markers
vary
between
different
types
cancer.
Properties
associated
epithelial-to-mesenchymal
transition
stemness
been
identified
CTCs,
indicating
increased
capacity.
Only
a
small
proportion
can
survive
eventually
initiate
metastases,
suggesting
an
interaction
modulation
hostile
microenvironment
essential
CTC
Single-cell
sequencing
extensively
investigated,
enabled
researchers
reveal
genome
transcriptome
CTCs.
Herein,
we
also
review
applications
especially
monitoring
response
treatment
evaluating
prognosis.
Hence,
will
continue
contribute
providing
significant
insights
processes
open
new
avenues
useful
applications.
Journal of Hematology & Oncology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: Sept. 8, 2022
Abstract
Epithelial–mesenchymal
transition
(EMT)
is
an
essential
process
in
normal
embryonic
development
and
tissue
regeneration.
However,
aberrant
reactivation
of
EMT
associated
with
malignant
properties
tumor
cells
during
cancer
progression
metastasis,
including
promoted
migration
invasiveness,
increased
stemness,
enhanced
resistance
to
chemotherapy
immunotherapy.
tightly
regulated
by
a
complex
network
which
orchestrated
several
intrinsic
extrinsic
factors,
multiple
transcription
post-translational
control,
epigenetic
modifications,
noncoding
RNA-mediated
regulation.
In
this
review,
we
described
the
molecular
mechanisms,
signaling
pathways,
stages
tumorigenesis
involved
discussed
dynamic
non-binary
its
role
metastasis.
Finally,
summarized
challenges
immunotherapy
proposed
strategies
for
therapy
targeting
EMT.
MedComm,
Journal Year:
2022,
Volume and Issue:
3(3)
Published: Aug. 2, 2022
The
heat
shock
proteins
(HSPs)
are
ubiquitous
and
conserved
protein
families
in
both
prokaryotic
eukaryotic
organisms,
they
maintain
cellular
proteostasis
protect
cells
from
stresses.
HSP
classified
based
on
their
molecular
weights,
mainly
including
large
HSPs,
HSP90,
HSP70,
HSP60,
HSP40,
small
HSPs.
They
function
as
chaperons
work
an
integrated
network,
participating
the
folding
of
newly
synthesized
polypeptides,
refolding
metastable
proteins,
complex
assembly,
dissociating
aggregate
dissociation,
degradation
misfolded
proteins.
In
addition
to
chaperone
functions,
also
play
important
roles
cell
signaling
transduction,
cycle,
apoptosis
regulation.
Therefore,
malfunction
HSPs
is
related
with
many
diseases,
cancers,
neurodegeneration,
other
diseases.
this
review,
we
describe
current
understandings
about
mechanisms
major
HSP90/HSP70/HSP60/HSP110
how
keep
response
stresses,
discuss
diseases
recent
exploration
therapy
diagnosis
modulate
These
research
advances
offer
new
prospects
potential
targets
for
therapeutic
intervention.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Nov. 8, 2022
Abstract
As
an
evolutionarily
conserved
signalling
network,
the
Hippo
pathway
plays
a
crucial
role
in
regulation
of
numerous
biological
processes.
Thus,
substantial
efforts
have
been
made
to
understand
upstream
signals
that
influence
activity
pathway,
as
well
its
physiological
functions,
such
cell
proliferation
and
differentiation,
organ
growth,
embryogenesis,
tissue
regeneration/wound
healing.
However,
dysregulation
can
cause
variety
diseases,
including
cancer,
eye
cardiac
pulmonary
renal
hepatic
immune
dysfunction.
Therefore,
therapeutic
strategies
target
dysregulated
components
might
be
promising
approaches
for
treatment
wide
spectrum
diseases.
Here,
we
review
key
critical
functions
controlled
by
pathway.
Additionally,
diseases
associated
with
alterations
potential
therapies
targeting
will
discussed.
Journal of Translational Medicine,
Journal Year:
2020,
Volume and Issue:
18(1)
Published: Jan. 3, 2020
Abstract
The
present
review
aimed
to
discuss
contemporary
scientific
literature
involving
differences
between
the
tumor
microenvironment
(TME)
in
melanoma,
lung
cancer,
and
breast
cancer
their
primary
site
TME
brain
metastases
(BM).
plays
a
fundamental
role
behavior
of
cancer.
In
process
carcinogenesis,
cells
such
as
fibroblasts,
macrophages,
endothelial
cells,
natural
killer
other
can
perpetuate
progress
carcinogenesis
via
secretion
molecules.
Oxygen
concentration,
growth
factors,
receptors
initiate
angiogenesis
are
examples
importance
microenvironmental
conditions
performance
neoplastic
cells.
most
frequent
malignant
tumors
metastatic
origin
primarily
originate
from
melanoma.
Metastatic
have
adhere
penetrate
blood–brain
barrier
(BBB).
After
traversing
BBB,
these
survive
by
producing
various
cytokines,
chemokines,
mediators
modify
new
TME.
is
currently
being
studied
owing
discovery
therapeutic
targets.
three
types
tumors,
treatment
more
effective
than
BM
due
several
including
BBB.
Understanding
characteristics
surrounding
respective
metastasis
might
help
improve
strategies
comprehend
Cancer Communications,
Journal Year:
2021,
Volume and Issue:
41(3), P. 199 - 217
Published: Jan. 27, 2021
Abstract
Epithelial‐to‐mesenchymal
transition
(EMT)
is
implicated
in
a
wide
array
of
malignant
behaviors
cancers,
including
proliferation,
invasion,
and
metastasis.
Most
notably,
previou
studies
have
indicated
that
both
cancer
stem‐like
properties
drug
resistance
were
associated
with
EMT.
Furthermore,
microRNAs
(miRNAs)
play
pivotal
role
the
regulation
EMT
phenotype,
as
result,
some
miRNAs
impact
stemness
resistance.
Therefore,
understanding
relationship
between
EMT‐associated
stemness/drug
beneficial
to
basic
research
clinical
treatment.
In
this
review,
we
preliminarily
looked
into
various
roles
nature
cells.
Then,
reviewed
interaction
drug‐resistant
complex
signaling
pathways
multiple
cancers
lung
cancer,
gastric
gynecologic
breast
liver
colorectal
pancreatic
esophageal
nasopharyngeal
cancer.
We
finally
discussed
EMT,
stemness,
resistance,
well
forward
potential
applications
miRNA
therapy
for
tumors.
