Foods,
Journal Year:
2021,
Volume and Issue:
10(4), P. 798 - 798
Published: April 8, 2021
Notwithstanding
the
increased
toxic
heavy
metals/metalloids
(THMs)
accumulation
in
(edible)
organs
owed
to
goat′s
feeding
habit
and
anthropogenic
activities,
chevon
remains
increasingly
relished
as
a
special
delicacy
Nigeria.
Specific
South-Eastern
region,
however,
there
is
paucity
of
relevant
data
regarding
prevalence
THMs
goat
carcasses
processed
for
human
consumption.
This
work
was,
therefore,
aimed
investigate
detection,
distribution
health
risk
assessment
carcass
consumption
To
achieve
this,
total
450
meat
samples
(kidney,
liver
muscle)
were
evaluated
from
150
randomly
selected
two
major
slaughterhouses
Enugu
State.
The
distribution,
well
parameters
followed
standard
procedures.
Results
revealed
that
at
least
one
THM
was
detected
56%
carcasses.
Mean
concentrations
arsenic
(As)
0.53
±
0.10
mg/kg,
0.57
0.09
mg/kg
0.45
0.08
lead
(Pb)
0.48
0.38
0.24
0.82
0.39
cadmium
(Cd)
0.06
0.32
0.02
0.00
kidney,
muscle
tissues,
respectively.
estimated
daily
intakes
(EDI)
all
above
recommended
safe
limits.
target
hazard
quotient
(THQ)
index
(HI)
computed
As,
Cd
Pb
fell
below
unity
studied
organs,
which
indicated
no
non-carcinogenic
risks.
Curtailing
activities
aid
THM-contamination
production/processing
lines
recommended.
Screening
Nigerian
imperative,
so
ascertain
toxicological
safety
meats
intended
The Annual Review of Pharmacology and Toxicology,
Journal Year:
2021,
Volume and Issue:
61(1), P. 47 - 63
Published: Jan. 6, 2021
Arsenic
is
a
naturally
occurring
metalloid
and
one
of
the
few
metals
that
can
be
metabolized
inside
human
body.
The
pervasive
presence
arsenic
in
nature
anthropogenic
sources
from
agricultural
medical
use
have
perpetuated
exposure
to
this
toxic
carcinogenic
element.
Highly
exposed
individuals
are
susceptible
various
illnesses,
including
skin
disorders;
cognitive
impairment;
cancers
lung,
liver,
kidneys.
In
fact,
across
globe,
approximately
200
million
people
potentially
levels
arsenic,
which
has
prompted
substantial
research
mitigation
efforts
combat
extensive
public
health
issue.
This
review
provides
an
up-to-date
look
at
arsenic-related
challenges
facing
global
community,
current
disease
burden,
resistance,
shortcomings
ongoing
measures,
discusses
potential
next
steps.
Geoscience Frontiers,
Journal Year:
2021,
Volume and Issue:
13(1), P. 101147 - 101147
Published: Jan. 20, 2021
Air
pollution
by
particulate
matter
(PM)
is
one
of
the
main
threats
to
human
health,
particularly
in
large
cities
where
levels
are
continually
exceeded.
According
their
source
emission,
geography,
and
local
meteorology,
pollutant
particles
vary
size
composition.
These
conditioned
aerodynamic
diameter
thus
classified
as
coarse
(2.5–10
μm),
fine
(0.1–2.5
ultrafine
(<0.1
degree
toxicity
becomes
greater
for
smaller
particles.
can
get
into
lungs
translocate
vital
organs
due
size,
causing
significant
health
consequences.
Besides,
PM
pollutants
have
been
linked
respiratory
conditions,
genotoxic,
mutagenic,
carcinogenic
activity
beings.
This
paper
presents
an
overview
emission
sources,
physicochemical
characteristics,
collection
measurement
methodologies,
toxicity,
existing
control
mechanisms
(UFPs)
last
fifteen
years.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Jan. 3, 2024
Abstract
Zinc
metabolism
at
the
cellular
level
is
critical
for
many
biological
processes
in
body.
A
key
observation
disruption
of
homeostasis,
often
coinciding
with
disease
progression.
As
an
essential
factor
maintaining
equilibrium,
zinc
has
been
increasingly
spotlighted
context
development.
Extensive
research
suggests
zinc’s
involvement
promoting
malignancy
and
invasion
cancer
cells,
despite
its
low
tissue
concentration.
This
led
to
a
growing
body
literature
investigating
metabolism,
particularly
functions
transporters
storage
mechanisms
during
transportation
under
control
two
major
transporter
families:
SLC30
(ZnT)
excretion
SLC39
(ZIP)
intake.
Additionally,
this
element
predominantly
mediated
by
metallothioneins
(MTs).
review
consolidates
knowledge
on
signaling
underscores
potential
molecular
pathways
linking
progression,
special
focus
cancer.
We
also
compile
summary
clinical
trials
involving
ions.
Given
main
localization
cell
membrane,
targeted
therapies,
including
small
molecules
monoclonal
antibodies,
offers
promising
avenues
future
exploration.
Carcinogenesis,
Journal Year:
2020,
Volume and Issue:
41(9), P. 1161 - 1172
Published: July 13, 2020
Abstract
Many
metals
are
essential
for
living
organisms,
but
at
higher
doses
they
may
be
toxic
and
carcinogenic.
Metal
exposure
occurs
mainly
in
occupational
settings
environmental
contaminations
drinking
water,
air
pollution
foods,
which
can
result
serious
health
problems
such
as
cancer.
Arsenic
(As),
beryllium
(Be),
cadmium
(Cd),
chromium
(Cr)
nickel
(Ni)
classified
Group
1
carcinogens
by
the
International
Agency
Research
on
Cancer.
This
review
provides
a
comprehensive
summary
of
current
concepts
molecular
mechanisms
metal-induced
carcinogenesis
focusing
variety
pathways,
including
genotoxicity,
mutagenesis,
oxidative
stress,
epigenetic
modifications
DNA
methylation,
histone
post-translational
modification
alteration
microRNA
regulation,
competition
with
metal
ions
cancer-related
signaling
pathways.
takes
broader
perspective
aims
to
assist
guiding
future
research
respect
prevention
therapy
human
diseases
Clinical and Translational Gastroenterology,
Journal Year:
2019,
Volume and Issue:
10(6), P. e00027 - e00027
Published: June 1, 2019
The
Toxic-metabolic,
Idiopathic,
Genetic,
Autoimmune,
Recurrent
and
severe
acute
pancreatitis
Obstructive
(TIGAR-O)
Pancreatitis
Risk/Etiology
Checklist
(TIGAR-O_V1)
is
a
broad
classification
system
that
lists
the
major
risk
factors
etiologies
of
recurrent
pancreatitis,
chronic
overlapping
pancreatic
disorders
with
or
without
genetic,
immunologic,
metabolic,
nutritional,
neurologic,
metaplastic,
other
features.
New
discoveries
progressive
concepts
since
2001
TIGAR-O
list
relevant
to
understanding
managing
complex
require
an
update
TIGAR-O_V2
both
short
(S)
long
(L)
form.
revised
designed
as
hierarchical
checklist
for
health
care
workers
quickly
document
track
specific
that,
alone
in
combinations,
may
contribute
disease
individual
patients
groups
assist
treatment
selection.
rationale
key
clinical
considerations
are
summarized
each
updated
item.
Familiarity
structured
format
speeds
up
completion
process
supports
thoroughness
consideration
alternative
diagnoses
during
evaluation
serves
framework
communication.
approach
also
facilitates
new
information
technologies
required
high-quality
data
accurate
precision
medicine.
A
use
primer
accompanies
comments
industries
caring
diseases.
