Pre-eclampsia

Nature Reviews Disease Primers, Journal Year: 2023, Volume and Issue: 9(1)

Published: Feb. 16, 2023

Language: Английский

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Severity of Anemia During Pregnancy and Adverse Maternal and Fetal Outcomes

JAMA Network Open, Journal Year: 2022, Volume and Issue: 5(2), P. e2147046 - e2147046

Published: Feb. 3, 2022

Importance

Anemia is the most widespread nutritional deficiency among pregnant females in world. Despite numerous studies on anemia, evidence limited about association of severity anemia with maternal and fetal health.

Objective

To investigate between during pregnancy risk adverse outcomes.

Design, Setting, Participants

This retrospective cohort study used data from China’s Hospital Quality Monitoring System January 1, 2016, to December 31, 2019, for aged 15 49 years birth outcomes reported at 1508 hospitals maternity services mainland China.

Exposures

varying was identified daily standardized electronic inpatient discharge records using corresponding codes theInternational Statistical Classification Diseases Related Health Problems, Tenth Revision. Mild defined as a hemoglobin concentration 100 109 g/L (to convert g/dL, divide by 10.0); moderate 70 99 g/L; severe less than g/L.

Main Outcomes Measures

The main included 6 (placental abruption, preterm birth, postpartum hemorrhage, shock, admission intensive care unit [ICU], mortality) 3 neonatal (fetal growth restriction, malformation, stillbirth). Multivariable logistic regression models were estimate odds ratios (ORs) 95% CIs these anemia.

Results

Among 18 948 443 (mean [SD] age, 29.42 [4.87] years), 17.78% diagnosed pregnancy, including 9.04% mild 2.62% 0.21% 5.90% unknown severity. Compared no associated increased risks placental abruption (mild: adjusted OR [aOR], 1.36 [95% CI, 1.34-1.38]; moderate: aOR, 1.98 1.93-2.02]; severe: 3.35 3.17-3.54]), 1.08 1.07-1.08]; 1.18 1.17-1.19]; 1.32-1.41]), hemorrhage 1.45 1.43-1.47]; 3.53 3.47-3.60]; 15.65 15.10-16.22]), malformation 1.15 1.14-1.17]; 1.19 1.16-1.21]; 1.62 1.52-1.73]). or shock (moderate: 1.50 1.41-1.60]; 14.98 13.91-16.13]), ICU 1.01-1.16]; 2.88 2.55-3.25]), death 0.45 0.30-0.65]; 1.56 0.97-2.48], restriction 0.80 0.78-0.82]; 1.00-1.17]), stillbirth aOR,0.79 0.76-0.81]; 1.86 1.75-1.98]), decreased (maternal shock: 0.67 0.63-0.71]; admission: 0.76-0.84]; death: 0.37 0.29-0.49]; restriction: 0.79 0.77-0.80]; stillbirth: 0.59 0.58-0.61]) after adjusting sociodemographic characteristics other complications pregnancy.

Conclusions Relevance

findings suggest that health improved survival growth. Further work needed validate which optimal are achieved.

Language: Английский

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Guidelines for the measurement of vascular function and structure in isolated arteries and veins

AJP Heart and Circulatory Physiology, Journal Year: 2021, Volume and Issue: 321(1), P. H77 - H111

Published: May 14, 2021

The measurement of vascular function in isolated vessels has revealed important insights into the structural, functional, and biomechanical features normal diseased cardiovascular system provided a molecular understanding cells that constitutes arteries veins their interaction. Further, this approach allowed discovery vital pharmacological treatments for diseases. However, expansion physiology field also brought new concerns over scientific rigor reproducibility. Therefore, it is appropriate to set guidelines best practices evaluating vessels. These are comprehensive document detailing pitfalls assessment large small veins. Herein, we bring together experts with purpose developing ex vivo function. By using document, physiologists will have consistency among methodological approaches, producing more reliable reproducible results.

Language: Английский

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Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Arrhythmias in Pregnancy

JACC. Clinical electrophysiology, Journal Year: 2021, Volume and Issue: 8(1), P. 120 - 135

Published: Dec. 22, 2021

Language: Английский

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Vascular changes in the cycling and early pregnant uterus

JCI Insight, Journal Year: 2023, Volume and Issue: 8(11)

Published: June 7, 2023

Uterine vascular remodeling is intrinsic to the cycling and early pregnant endometrium. Maternal regulatory factors such as ovarian hormones, VEGF, angiopoietins, Notch, uterine natural killer cells significantly mediate these changes. In absence of pregnancy, changes in vessel morphology function correlate with different stages human menstrual cycle. During rodents humans results decreased resistance increased permeability necessary for pregnancy success. Aberrations adaptive processes contribute risk infertility, abnormal fetal growth, and/or preeclampsia. This Review comprehensively summarizes cycle, peri- post-implantation rodent species (mice rats).

Language: Английский

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Understanding the Importance of the Small Artery Media–Lumen Ratio: Past and Present

Basic & Clinical Pharmacology & Toxicology, Journal Year: 2025, Volume and Issue: 136(2)

Published: Jan. 13, 2025

ABSTRACT The media–lumen diameter ratio of small arteries is increased in hypertension, diabetes and obesity. It likely that both shear stress on the endothelial cells, transmural pressure smooth muscle cell tone are important for altered vascular structure. However, precise interaction importance these factors incompletely understood. At molecular level transglutaminases, metalloproteinases, integrins, NO several other have been suggested to be important, but our understanding how many together control structure surprisingly limited. has prognostic value, which independent classical risk cardiovascular disease. Importantly this also case patients treated pharmacologically high blood pressure. therefore relevant consider artery as a potential target relation prevention

Language: Английский

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Blood Vessels and Vascular Niches in Bone Development and Physiological Remodeling

Frontiers in Cell and Developmental Biology, Journal Year: 2020, Volume and Issue: 8

Published: Nov. 27, 2020

Recent advances in our understanding of blood vessels and vascular niches bone convey their critical importance regulating development physiology. The contribution functions remodeling has recently gained enormous interest because therapeutic potential. mammalian skeletal system performs multiple the body to regulate growth, homeostasis metabolism. Blood provide support various cell types maintain functional marrow microenvironment. Heterogeneity within indicate specialized functions. In this review, we discuss physiology vasculature for hematopoietic stem cells mesenchymal progenitor cells. We clinical experimental information available on during physiological remodeling.

Language: Английский

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Fetal Growth Restriction: Does an Integrated Maternal Hemodynamic-Placental Model Fit Better?

Reproductive Sciences, Journal Year: 2020, Volume and Issue: 28(9), P. 2422 - 2435

Published: Nov. 19, 2020

Abstract In recent years, a growing interest has arisen regarding the possible relationship between adverse pregnancy outcomes (APOs) and inadequate maternal hemodynamic adaptations to pregnancy. A association “placental syndromes,” such as preeclampsia (PE) fetal growth restriction (FGR), subsequent cardiovascular diseases (CVD) later in life been reported. The two subtypes of FGR show different pathogenetic clinical features. Defective placentation, due poor trophoblastic invasion spiral arteries, is believed play central role pathogenesis early-onset PE FGR. Since placental functioning dependent on system, pre-existent or impairment may key Late does not seem be determined by primary abnormal placentation first trimester. pathological pathway late-onset maladaptation: CV system shows flat profile remains similar those non-pregnant women. second trimester, when placenta already developed increases its functional request, hypovolemic state could lead hypoperfusion an altered maturation villous tree therefore growth. Thus, this review focalizes cardiac function development both early better understanding hemodynamics pregnancies complicated bring various benefits practice, improving screening therapeutic tools.

Language: Английский

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Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease

Heart, Journal Year: 2021, Volume and Issue: 107(21), P. 1704 - 1709

Published: Jan. 19, 2021

Background Cardiovascular disease is the leading cause of death during pregnancy with thoracic aortic dissection being one main causes. Thoracic commonly related to hereditary disorders and congenital heart malformations such as bicuspid valve (BAV). Pregnancy considered a high risk period in women underlying aortopathy. Methods The ESC EORP Registry Of And Cardiac (ROPAC) prospective global registry that enrolled 5739 pre-existing cardiac disease. With this analysis, we aim study maternal fetal outcome Results was reported 189 (3.3%). Half them were patients Marfan syndrome (MFS), 26% had BAV, 8% Turner syndrome, 2% vascular Ehlers-Danlos 11% no genetic defect or associated defect. Aortic dilatation 58% 6% history dissection. Four patients, whom three MFS, an acute (three type A B dissection) without mortality. No complications occurred There significant difference median birth weight if treated beta-blocker not (2960 g (2358–3390 g) vs 3270 (2750–3570 g), p value 0.25). Conclusion This ancillary analysis provides largest data review on for Overall outcomes followed according current guidelines are good.

Language: Английский

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