The mechanism of ferroptosis and its related diseases

Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)

Published: Oct. 16, 2023

Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.

Language: Английский

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Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Language: Английский

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Ferroptosis: Mechanisms and role in diabetes mellitus and its complications

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 94, P. 102201 - 102201

Published: Jan. 19, 2024

Language: Английский

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Ferroptosis and metabolic syndrome and complications: association, mechanism, and translational applications

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Metabolic syndrome is a medical condition characterized by several metabolic disorders in the body. Long-term raise risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Therefore, it essential to actively explore aetiology (MetS) its comorbidities provide effective treatment options. Ferroptosis new form cell death that iron overload, lipid peroxide accumulation, decreased glutathione peroxidase 4(GPX4) activity, involves pathological processes variety diseases. Lipid deposition caused diseases overload significant syndrome, providing theoretical conditions for developing ferroptosis. Recent studies have found major molecules ferroptosis are linked common consequences, such as T2DM atherosclerosis. In this review, we first discussed mechanics ferroptosis, regulatory function inducers inhibitors significance loading MetS. Next, summarized role pathogenesis MetS, obesity, diabetes, Finally, relevant ferroptosis-targeted therapies raised some crucial issues concern directions future Mets-related treatments research.

Language: Английский

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Iron deficiency and supplementation in heart failure

Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(7), P. 463 - 486

Published: Feb. 7, 2024

Language: Английский

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Integration of epidemiological and blood biomarker analysis links haem iron intake to increased type 2 diabetes risk

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(9), P. 1807 - 1818

Published: Aug. 13, 2024

Language: Английский

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Nanoadjuvant-triggered STING activation evokes systemic immunotherapy for repetitive implant-related infections

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 82 - 98

Published: Jan. 24, 2024

Repetitive implant-related infections (IRIs) are devastating complications in orthopedic surgery, threatening implant survival and even the life of host. Biofilms conceal bacterial-associated antigens (BAAs) result a "cold tumor"-like immune silent microenvironment, allowing persistence IRIs. To address this challenge, an iron-based covalent organic framed nanoadjuvant doped with curcumin platinum (CFCP) was designed present study to achieve efficient treatment IRIs by inducing systemic response. Specifically, enhanced sonodynamic therapy (SDT) from CFCP combined iron ion metabolic interference increased release double-stranded DNA (dsDNA). Immunogenic dsDNA promoted dendritic cell (DC) maturation through activation stimulator interferon gene (STING) amplified stimulation neutrophils via interferon-β (IFN-β). At same time, BAA presentation aroused humoral immunity B T cells, creating long-term resistance repetitive infections. Encouragingly, served as neoadjuvant immunotherapy for sustained antibacterial protection on implants expected guide clinical IRI relapse prevention.

Language: Английский

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The Importance and Essentiality of Natural and Synthetic Chelators in Medicine: Increased Prospects for the Effective Treatment of Iron Overload and Iron Deficiency

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4654 - 4654

Published: April 25, 2024

The supply and control of iron is essential for all cells vital many physiological processes. All functions activities are expressed in conjunction with iron-binding molecules. For example, natural chelators such as transferrin chelator–iron complexes haem play major roles metabolism human physiology. Similarly, the mainstay treatments most common diseases metabolism, namely deficiency anaemia overload, involve iron–chelator iron-chelating drugs deferiprone (L1), deferoxamine (DF) deferasirox. Endogenous citric acid glutathione exogenous ascorbic also important homeostasis. Recent advances treatment effective ferric tri-maltol complex (feraccru or accrufer) transfusional overload using L1 L1/DF combinations have decreased associated mortality morbidity improved quality life millions patients. Many other chelating ciclopirox, dexrazoxane EDTA used daily by patients diseases. their metabolites iron-chelation capacity hydroxyurea, tetracyclines, anthracyclines aspirin, well dietary molecules gallic acid, caffeic quercetin, ellagic maltol phytochelators, known to interact affect related Different interactions observed presence essential, xenobiotic, diagnostic theranostic metal ions competing iron. Clinical trials Parkinson’s, Alzheimer’s neurodegenerative diseases, HIV infections, cancer, diabetic nephropathy inflammation, highlight importance chelation therapy clinical conditions. proposed use modulating ferroptosis signifies a new era design therapeutic strategies introduction artificial intelligence guidance optimal outcomes personalised medicine expected increase further impact medicine, survival metabolic disorders

Language: Английский

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Iron-Mediated Regulation in Adipose Tissue: A Comprehensive Review of Metabolism and Physiological Effects

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 3, 2025

Language: Английский

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Dysregulated Iron Homeostasis as Common Disease Etiology and Promising Therapeutic Target

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 671 - 671

Published: March 9, 2023

Iron is irreplaceably required for animal and human cells as it provides the activity center a wide variety of essential enzymes needed energy production, nucleic acid synthesis, carbon metabolism cellular defense. However, iron toxic when present in excess its uptake storage must, therefore, be tightly regulated to avoid damage. A growing body evidence indicates that dysregulation leading quantities free reactive responsible range otherwise discrete diseases. can promote proliferative diseases such infections cancer by supplying pathogens or cells. Toxicity from plays roles pathogenesis various metabolic, neurological inflammatory Interestingly, common underlying aspect these conditions availability iron. This underpinning potential new therapeutic avenue. Existing hematologically used chelators take up have shown serious limitations use but purpose-designed development show promise suppressing microbial pathogen cell growth, also relieving iron-induced toxicity other Hepcidin hepcidin agonists are showing dysregulation. Harnessing iron-driven oxygen species (ROS) generation with ferroptosis has selective destruction We review biological requirements, regulation nature Current results pertaining therapies reviewed.

Language: Английский

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