Rejuvenation Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
Observational
studies
and
clinical
trials
indicate
a
link
between
arterial
stiffness
(AS)
sarcopenia
(SAR),
yet
the
causal
relationship
these
remains
unclear.
The
study
aims
to
investigate
connection
from
AS
SAR
by
Mendelian
randomization
(MR).
We
analyzed
Genome-Wide
Association
Studies
data
for
indicators:
pulse
wave
index
(PWASI)
peak-to-peak
time
(PPT),
low
hand
grip
strength
(LHGS),
usual
walking
pace
(UWP),
moderate-to-vigorous
physical
activity
levels
(MVPA),
walk
or
cycle
unassisted
10
minutes.
inverse
variance-weighted,
MR-Egger,
weighted
mode,
median
were
applied
MR.
There
is
bidirectional
SAR.
PWASI
has
causation
with
UWP
(odds
ratio
[OR]
=
0.97,
95%
confidence
interval
[CI]
0.94-0.99).
PPT
association
MVPA
(OR
1.08,
CI
1.002-1.144)
1.05,
1.017-1.096).
LHGS
causally
associated
0.95,
0.91-0.98)
0.77,
0.65-0.90)
1.37,
1.17-1.60).
increased
could
reduce
motor
ability
slightly
lower
upper
limb
lead
higher
AS.
This
of
two
may
offer
novel
perspectives
advancing
understanding
underlying
mechanisms
related
muscle
pathophysiology.
Cells,
Journal Year:
2024,
Volume and Issue:
13(17), P. 1469 - 1469
Published: Sept. 1, 2024
NAD+-dependent
deacetylase
sirtuin-1
(Sirt1)
belongs
to
the
sirtuins
family,
known
be
longevity
regulators,
and
exerts
a
key
role
in
prevention
of
vascular
aging.
By
aging,
expression
levels
Sirt1
decline
with
severe
impact
on
function,
such
as
rise
endothelial
dysfunction,
which
turn
promotes
development
cardiovascular
diseases.
In
this
context,
activity
preventing
senescence
is
particularly
important.
Given
counteracting
senescence,
great
efforts
have
been
made
deepen
knowledge
about
intricate
cross-talks
interactions
other
molecules,
order
set
up
possible
strategies
boost
prevent
or
treat
The
aim
review
provide
proper
background
regulation
function
endothelium
discuss
recent
advances
regarding
therapeutic
targeting
counteract
AJP Cell Physiology,
Journal Year:
2025,
Volume and Issue:
328(2), P. C467 - C482
Published: Jan. 7, 2025
As
a
hallmark
of
chronic
kidney
disease
(CKD),
arterial
stiffening
is
related
to
increased
vascular
inflammation
and
cardiovascular
morbidity,
whereas
the
underlying
mechanism
unclear.
The
study
demonstrates
that
stiffness
precedes
onset
inflammation,
matrix
stimulates
transdifferentiation
smooth
muscle
cells
(VSMCs)
an
inflammatory
phenotype
via
activating
Runx2-NLRP3
signaling,
which
provides
novel
insights
into
CKD-related
disorder
treatment.
The Open Cardiovascular Medicine Journal,
Journal Year:
2025,
Volume and Issue:
19(1)
Published: Feb. 4, 2025
Considering
that
the
risks
of
cardiovascular
disease
still
pose
a
significant
challenge
despite
preventive
and
therapeutic
efforts,
we
need
new
pathophysiological
models
for
better
understanding
treatment
based
on
concepts.
Arterial
Stiffness
(AS)
has
been
increasingly
studied
as
an
independent
risk
factor.
The
mechanisms
by
which
AS
develops
are
not
yet
fully
understood.
However,
it
clearly
involves
only
structural
changes
but
also
endothelial
functional
changes.
There
several
clinical
studies
showing
vascular
damage
is
important
factor
injury
high-flow
organs.
Carotid-femoral
Pulse
Wave
Velocity
(PWV-cf)
considered
gold
standard
evaluation
AS,
with
large
body
evidence
demonstrating
its
association
disease,
regardless
traditional
factors.
Based
impact
high
PWV-cf
prognosis,
achieving
decrease
in
PWV
would
possibly
reduce
events.
significance
lowering
to
events
under
remains
be
unequivocally
demonstrated.
Regarding
resistant
hypertension,
shares
factors
including
advanced
age,
dysfunction,
left
ventricular
hypertrophy,
obesity,
diabetes,
chronic
kidney
disease.
On
other
hand,
increased
hypertensives
presents
two-way
interaction,
where
uncontrolled
blood
pressure
results
progressive
while
stiffness
increases
pressure,
making
control
more
difficult
establishing
vicious
circle.
In
this
scenario,
complex
interaction
development,
options
should
become
clinically
available.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(4), P. 899 - 899
Published: April 8, 2025
Background/Objectives:
Vascular
function
measurements,
including
central
parameters
[pulse
wave
velocity
(PWV)
and
augmentation
index
(AI)],
as
well
peripheral
measures
[finger
photoplethysmography
fitness
(PPGF)],
have
been
introduced
to
detect
early
vascular
damage
associated
with
coronary
artery
disease
(CAD)
risk
factors.
This
study
aimed
compare
marker
levels
among
subjects
hypertension
(HPT),
dyslipidemia,
obesity.
We
also
determine
the
relationship
between
these
markers
CAD
factors
groups.
Methods:
A
total
of
320
healthy
individuals
those
were
recruited.
Peripheral
was
assessed
using
PPGF,
whereas
included
measurements
PWV
AI.
The
Framingham
score
(FRS)
calculated
an
online
calculator.
Results:
mean
age
33.73
±
7.29
years.
AI
significantly
higher
in
HPT
(8.03
1.40
m/s
21.90%
10.57%)
than
control.
PPGF
showed
no
significant
differences
FRS
dyslipidemia
groups,
obese
group.
associations
Conclusions:
serve
robust
macrovascular
indicating
arterial
stiffness
systemic
resistance
linked
risk,
while
a
microvascular
marker,
offers
valuable
insights
into
endothelial
dysfunction
microcirculatory
anomalies,
especially
subjects.
The Journal of Cardiovascular Aging,
Journal Year:
2025,
Volume and Issue:
5(2)
Published: April 22, 2025
Cardiovascular
aging
underpins
the
development
of
age-related
diseases,
including
heart
failure
and
vascular
dysfunction,
is
driven
by
molecular
cellular
mechanisms
described
in
hallmarks
aging.
Plasminogen
activator
inhibitor-1
(PAI-1),
a
key
regulator
fibrinolysis,
also
mediates
processes
like
stiffness,
senescence,
immune
evasion.
This
review
highlights
PAI-1’s
role
cardiovascular
with
special
emphasis
on
hallmark
It
further
explores
therapeutic
potential,
focus
its
contribution
to
ECM
remodeling,
senescence
signaling,
checkpoint
regulation.
Targeting
PAI-1
could
provide
promising
strategy
mitigate
disease.
Acta Biomaterialia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Platelets
have
long
been
established
as
a
safeguard
of
our
vascular
system.
Recently,
haptotactic
platelet
migration
has
discovered
part
the
immune
response.
In
addition,
platelets
exhibit
mechanosensing
properties,
changing
their
behavior
in
response
to
stiffness
underlying
substrate.
However,
influence
substrate
on
remains
elusive.
Here,
we
investigated
fibrinogen-coated
polydimethylsiloxane
(PDMS)
substrates
with
different
stiffnesses.
Using
phase-contrast
and
fluorescence
microscopy
well
deep-learning
neural
network,
tracked
single
migrating
measured
distance
velocity.
We
found
that
migrated
stiff
PDMS
(E
=
2
MPa),
while
they
did
not
migrate
soft
5
kPa).
also
intermediate
100
kPa),
but
velocity
fraction
were
diminished
compared
substrates.
The
straightness
migration,
however,
was
significantly
influenced
by
stiffness.
used
scanning
ion
conductance
(SICM)
image
three-dimensional
shape
platelets,
finding
show
polarization
change
associated
migration.
Furthermore,
fibrinogen
density
gradient,
which
is
generated
reduced
for
Our
work
demonstrates
stiffness,
thus
mechanosensing,
influences
Substrate
optimal
quite
high
(>100
kPa)
comparison
other
cell
types,
possible
implications
inflammatory
injured
tissue.
STATEMENT
OF
SIGNIFICANCE:
can
feel
react
surroundings
-
process
called
mechanosensation.
Additionally,
via
substrate-bound
innate
during
injury
or
inflammation.
It
shown
cells
substrate,
effect
yet
investigated.
differently
made
from
PDMS,
affects
Stiff
facilitate
fast
frequent
strong
anisotropy
removal
inhibit
These
findings
highlight
surrounding
tissue
response,
possibly
enhancing
inflamed
