Neurovascular coupling actively regulates context-dependent emotional adjustment DOI Open Access
Jiayu Ruan,

Xinghua Quan,

Huiqi Xie

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 14, 2023

Abstract The ability to flexibly regulate emotions in a contextually appropriate manner is essential for individuals adapt varying social stresses, and companion inflexibility involves psychiatric diseases. extent of this flexibility can be quantified by measuring neurovascular coupling (NVC)-based hemodynamics signal through functional brain imaging. However, whether NVC, turn, plays an active role emotion regulation remains unknown due the absence exclusive strategies bidirectionally manipulating NVC. By establishing fifteen genetic mouse lines suppress or enhance we demonstrated that NVC allostatic component shapes flexibility. With deficits, same individual mice simultaneously exhibited being overwhelmed (hyper-response) suppressing (hypo-response), depending on different contexts. Surprisingly, knocking down vascular mural cell contractile protein, local suppression within basal lateral amygdala (BLA), central hub, induces hyper-response. Mechanistically, such opposite responses were likely attributed NVC’s BLA’s neural activity context-dependent manner. Importantly, BLA neuron-specific chemogenetic antagonization attenuate More importantly, enhancing alleviated emotional distress induced acute chronic restraint stress, highlighting potential as unique therapeutic target may avoid directly acting neurons. These findings indicate bidirectional modulation fit contexts appropriately, emphasizing necessity proper maintaining homeostasis advanced functions.

Language: Английский

Self-guided digital behavioural therapy versus active control for fibromyalgia (PROSPER-FM): a phase 3, multicentre, randomised controlled trial DOI

R Michael Gendreau,

Lance M. McCracken, David A. Williams

et al.

The Lancet, Journal Year: 2024, Volume and Issue: 404(10450), P. 364 - 374

Published: July 1, 2024

Language: Английский

Citations

9
Are people with chronic pain more diverse than we think? An investigation of ergodicity DOI Creative Commons
Felicia Sundström,

Amani Lavefjord,

Monica Buhrman

et al.

Pain, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract This study investigates whether data from people with endometriosis (n = 58) and fibromyalgia exhibit what is called “ergodicity,” meaning that results analyses of aggregated group can be used to support conclusions about the individuals within groups. The variables studied here are commonly investigated in chronic pain: pain intensity, interference, depressive symptoms, psychological flexibility, catastrophizing. Data were collected twice daily for 42 days each participant analyzed 2 ways: as separate cross-sectional studies using timepoints sets (between-person) individual longitudinal person's time series (within person). To confirm ergodicity, should agree. However, this not was observed several respects. between-person showed substantially less variability compared within-person data. evident both summary statistics involving single correlational analyses. Overall, correlations relatively restricted range, while varied widely. These findings have potentially profound implications field research. Because ergodicity found, raises doubts around assumption groups accurately represent range experiences pain. advocate a shift toward inclusion more person-focused approaches an addition group-based approaches. could lead personalized effective treatments by better capturing then clarifying heterogeneous nature pain, including processes underlie it.

Language: Английский

Citations

1
An investigation of the associations between stigma, self-compassion, and pain outcomes during treatment based on Acceptance and Commitment Therapy for chronic pain DOI Creative Commons

Madeleine Anderson,

Lance M. McCracken, Whitney Scott

et al.

Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 6, 2024

Introduction Stigma adversely affects people with chronic pain. The qualities within self-compassion may be particularly useful for buffering the impact of stigma on In context an Acceptance and Commitment Therapy-based (ACT) treatment pain, this study investigated association between changes in pain outcomes, potential moderating role outcomes. Materials methods Five-hundred nineteen patients completed standardized self-report questionnaires stigma, self-compassion, psychological flexibility, intensity interference, work social adjustment, depression symptoms at start interdisciplinary ACT-based same measures were post-treatment ( n = 431). Results results indicated that key outcomes significantly improved during treatment, but did not. Changes negatively correlated these variables associated improvements There significant main effects many pre- regression models when flexibility was not controlled for, moderate remained while Discussion findings add to our conceptual understanding inter-relationships can contribute advancements optimally target variables.

Language: Английский

Citations

4
Comprehensive and Efficient Assessment of Psychological Flexibility in the Context of Chronic Pain DOI Creative Commons

Amani Lavefjord,

Felicia Sundström, D Chia

et al.

European Journal of Pain, Journal Year: 2025, Volume and Issue: 29(2)

Published: Jan. 6, 2025

ABSTRACT Background The Multidimensional Psychological Flexibility Inventory (MPFI) is a measure of all facets psychological flexibility and inflexibility, potentially important processes change in treatment for chronic pain. In some contexts, it can be considered too long. aim this study was, therefore, to validate short form MPFI (MPFI‐24P) pain sample. Methods Adults with were recruited online ( N = 404) cross‐sectional survey study. They first completed background questions the MPFI. For examining convergent construct validity explained variance pain‐related outcomes, participants also Brief Pain (BPI) Interference Scale, Work Social Adjustment Scale (WSAS) Patient Health Questionnaire (PHQ‐9), depression measure. Data collected on two occasions, 2 weeks apart. Item response theory (IRT) confirmatory factor analysis (CFA) used selecting best‐performing items. Results IRT parameters overall adequate, hierarchical CFA demonstrated good model fit. Network items indicated that, general, intended same substantially interconnected, more so inflexibility Temporal stability was internal consistency good. MPFI‐24P correlated interference, work social adjustment depression, scale better predicting these outcomes. strongly full‐length Conclusions generally valid reliable, especially scale. It performs similarly Significance This paper contributes that both feasible use clinical practice research, while being able inflexibility—psychological are evaluate order individualize treatment.

Language: Английский

Citations

0
Pain DOI

Laura Nelson Darling,

Kristine Lee,

John D. Otis

et al.

Cambridge University Press eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 122 - 138

Published: Jan. 10, 2025

Citations

0
Pain Acceptance in Chronic Postoperative Pain: Concept Analysis DOI
Constance Johnson, Meagan Whisenant, Deniz Dishman

et al.

Pain Management Nursing, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Acceptance and Commitment Therapy for Well-Being at Worksites: Charting the Field for Enhancing Its Applicability DOI Creative Commons

Marta Vega-Campos,

Marta Pérez-Pérez, Carmen Sarabia‐Cobo

et al.

SAGE Open, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 1, 2025

The advent of the “New Era for Mental Health” has made management this intangible asset one hottest topics in workplace. It is leading cause disability today. Organizations are encouraged to use psychological interventions promote and prevent more sustainable productive workplaces. aim article develop an exploratory systematic mixed review that combines quantitative narrative analysis synthesize available literature on Acceptance Commitment Therapy (ACT) workplace—an increasingly popular therapy address challenge. This provides a comprehensive reflection existing state art, gaps current research, future directions topic. 59 articles collected from Web Science (WoS), Scopus, PubMed databases 2000 2023 reveals, firstly, ACT workplace increasing significantly, with upward trend over last 5 years presence high-impact journals. Secondly, research themes identified reveal intervention still focused clinical settings limited other sectors or organizational settings—such as education, business management, return-to-work programs. Based these results, underscores growing importance workplace, revealing seven opportunities extend its application across various accelerate effective implementation industry academia, thereby enhancing mental health productivity.

Language: Английский

Citations

0
Genetic causal effects of multi-site chronic pain on post-traumatic stress disorder: Evidence from a two-sample, two-step Mendelian randomization study DOI
Zuxing Wang,

Lu Qiao,

S Hou

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 138, P. 111307 - 111307

Published: March 3, 2025

Language: Английский

Citations

0
Effectiveness of peri-operative psychological interventions for the reduction of postsurgical pain intensity, depression, anxiety and pain catastrophising DOI
Juan R. Castaño-Asins, Alberto Barceló‐Soler, Estíbaliz Royuela-Colomer

et al.

European Journal of Anaesthesiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

BACKGROUND Evidence suggests that psychological interventions during the peri-operative period can help reduce development of chronic postsurgical pain (CPSP); however, there is no evidence their effects on other important pain-related variables. OBJECTIVES This systematic review and meta-analysis evaluated effectiveness for reduction intensity, depression, anxiety, stress catastrophising. STUDY DESIGN Systematic randomised controlled trials (RCTs) with meta-analyses (registration number: CRD42023403384). The search studies was carried out in Web Science, PsychINFO, MEDLINE CINAHL up to March 2023. ELIGIBILITY CRITERIA RCTs comparing usual care or nonpsychological control adult patients any type surgery. main outcome intensity after Secondary outcomes included patient-reported catastrophising RESULTS Twenty-seven (psychological intervention: 1462 patients; control: 1528 patients) were 17 meta-analysis. Random-effect models used combine effect sizes studies. Compared interventions, reduced d = -0.45 95% CI, (-0.77 -0.13) -0.33 (-0.54 -0.11) Moderator analyses revealed delivered by a psychologist more effective than those professionals. CBT seemed most beneficial surgical patients. findings moderator heterogeneous. CONCLUSIONS Moderate-quality exists significantly anxiety postsurgery. However, results should be interpreted caution because presence high risk bias many trials.

Language: Английский

Citations

0
User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: A Multi-Methods Study (Preprint) DOI Creative Commons

Afra S. Taygar,

Sara Laureen Bartels, Rocío de la Vega

et al.

Published: March 21, 2025

BACKGROUND Recent research shows that chronic pain affects 27% of the adult population. For many, is significantly impairing quality life and everyday functioning. Behavioral interventions have shown utility, but access remains limited. Digital health solutions can increase reach there a need for user-friendly, feasible, evidence-based digital interventions. OBJECTIVE This study aims to clarify how behavioral intervention be developed in user-centered approach address needs preferences target METHODS used multi-method develop prototypes across three phases: Preparation (Phase 0), Design 1), Testing 2). End-user involvement was prioritized through fictional Patient Personas, focus groups with patients (n=5) therapists (n=12), pilot testing (n=11 patients, n=3 therapists) intervention. RESULTS Based on end-user input, 6-week created. Focus highlighted importance accessibility adaptability Results from demonstrated usability CONCLUSIONS illustrated utility Personas when preparing, designing, feedback this new Findings indicated treatment promising, while also providing relevant suggestions guide further improvements.

Language: Английский

Citations

0