[68Ga]Ga-FAPI PET/CT in brain tumors: comparison with [18F]F-FDG PET/CT DOI Creative Commons
Ya Liu,

Haoyuan Ding,

Jianpeng Cao

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 6, 2024

To investigate the feasibility of [

Language: Английский

Personalised PET imaging in oncology: an umbrella review of meta-analyses to guide the appropriate radiopharmaceutical choice and indication DOI Creative Commons
Margarita Kirienko, Fabrizia Gelardi, Francesco Fiz

et al.

European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Language: Английский

Citations

7
From FDG and beyond: the evolving potential of nuclear medicine DOI
Kenji Hirata, Koji Kamagata, Daiju Ueda

et al.

Annals of Nuclear Medicine, Journal Year: 2023, Volume and Issue: 37(11), P. 583 - 595

Published: Sept. 25, 2023

Language: Английский

Citations

14
Fibroblast Activation Protein Alpha (FAPα) in Fibrosis: Beyond a Perspective Marker for Activated Stromal Cells? DOI Creative Commons
Nataliya Basalova, Natalya Alexandrushkina, Olga Grigorieva

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(12), P. 1718 - 1718

Published: Nov. 29, 2023

The development of tissue fibrosis is a complex process involving the interaction multiple cell types, which makes search for antifibrotic agents rather challenging. So far, myofibroblasts have been considered key type that mediated and thus was main target therapy. However, current strategies aimed at inhibiting myofibroblast function or eliminating them fail to demonstrate sufficient effectiveness in clinical practice. Therefore, today, there an unmet need more reliable cellular targets contribute resolution inhibition its progression. Activated stromal cells, capable active proliferation invasive growth into healthy tissue, appear be such population due their accessible localization high susceptibility various regulatory signals. This subpopulation marked by fibroblast activation protein alpha (FAPα). For long time, FAPα exclusively marker cancer-associated fibroblasts. accumulating data are emerging on diverse functions FAPα, suggests this not only but also plays important role review aims summarize expression, regulation, regarding identify promising advances area.

Language: Английский

Citations

14
Rational Design and Comparison of Novel 99mTc-Labeled FAPI Dimers for Visualization of Multiple Tumor Types DOI

Lingxin Meng,

Jianyang Fang, Jingru Zhang

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(10), P. 8460 - 8472

Published: May 8, 2024

Recognizing the significance of SPECT in nuclear medicine and pivotal role fibroblast activation protein (FAP) cancer diagnosis therapy, this study focuses on development 99mTc-labeled dimeric HF2 with high tumor uptake image contrast. The was synthesized radiolabeled 99mTc one pot using various coligands (tricine, TPPTS, EDDA, TPPMS) to yield [99mTc]Tc-TPPTS-HF2, [99mTc]Tc-EDDA-HF2, [99mTc]Tc-TPPMS-HF2 dimers. imaging results indicated that [99mTc]Tc-TPPTS-HF2 exhibited higher tumor-to-normal tissue (T/NT) ratio than [99mTc]Tc-EDDA-HF2 [99mTc]Tc-TPPMS-HF2. Notably, remarkable accumulation retention HT-1080-FAP U87-MG tumor-bearing mice, thereby surpassing monomeric [99mTc]Tc-TPPTS-HF. Moreover, achieved acceptable T/NT ratios hepatocellular carcinoma patient-derived xenograft (HCC-PDX) model, which provided identifiable contrast quality. In conclusion, presents proof-of-concept research FAP inhibitor dimers for visualization multiple types. Among these candidate compounds, showed excellent clinical potential, enriching tracer toolbox.

Language: Английский

Citations

6
[68Ga]Ga-FAPI PET/CT in brain tumors: comparison with [18F]F-FDG PET/CT DOI Creative Commons
Ya Liu,

Haoyuan Ding,

Jianpeng Cao

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 6, 2024

To investigate the feasibility of [

Language: Английский

Citations

6