Journal of The Electrochemical Society,
Journal Year:
2022,
Volume and Issue:
169(12), P. 127518 - 127518
Published: Dec. 1, 2022
Dopamine
is
an
important
neurotransmitter
for
organisms
and
affects
their
function,
so
monitoring
detecting
dopamine
levels
are
essential.
Sensitivity
selectivity
of
electrochemical
sensors
the
detection
usually
rely
on
hybrid
nanocomposites.
In
this
context,
we
designed
a
micro-regionally
restricted
nanocomposite
by
modulating
micro-nano
structure.
Using
functional
groups
nitrogen-doped
reduced
graphene
oxide
(N-rGO)
to
restrict
random
growth
tungsten
disulfide
nanosheets,
obtained
2D
layered
material
with
bidirectional
structural
support
achieve
high
specific
surface
activity
application
in
robust
novel
sensors.
A
facile
sensor
was
fabricated
modifying
screen-printed
carbon
electrode
nanocomposite.
The
exhibits
excellent
performance
wide
range
1
μ
mol
l
−1
–100
limit
0.2
sensitivity
0.56
.
optimized
shows
good
selectivity,
satisfactory
long-term
stability
reproducibility
towards
DA
separation
peak
potential
142
mV
uric
acid.
addition,
prepared
provides
favorable
recovery
human
serum
artificial
cerebrospinal
solution
(aSCF),
indicating
great
potentials
biological
sensing
applications.
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(9), P. 4469 - 4494
Published: Sept. 9, 2024
Lung
cancer
remains
a
global
health
concern,
demanding
the
development
of
noninvasive,
prompt,
selective,
and
point-of-care
diagnostic
tools.
Correspondingly,
breath
analysis
using
nanobiosensors
has
emerged
as
promising
noninvasive
nose-on-chip
technique
for
early
detection
lung
through
monitoring
diversified
biomarkers
such
volatile
organic
compounds/gases
in
exhaled
breath.
This
comprehensive
review
summarizes
state-of-the-art
breath-based
diagnosis
employing
chemiresistive-module
supported
by
theoretical
findings.
It
unveils
fundamental
mechanisms
biological
basis
biomarker
generation
associated
with
cancer,
technological
advancements,
clinical
implementation
nanobiosensor-based
analysis.
explores
merits,
challenges,
potential
alternate
solutions
implementing
these
settings,
including
standardization,
biocompatibility/toxicity
analysis,
green
sustainable
technologies,
life-cycle
assessment,
scheming
regulatory
modalities.
highlights
nanobiosensors'
role
facilitating
precise,
real-time,
on-site
leading
to
improved
patient
outcomes,
enhanced
management,
remote
personalized
monitoring.
Additionally,
integrating
biosensors
artificial
intelligence,
machine
learning,
Internet-of-things,
bioinformatics,
omics
technologies
is
discussed,
providing
insights
into
prospects
intelligent
sniffing
nanobiosensors.
Overall,
this
consolidates
knowledge
on
breathomic
biosensor-based
screening,
shedding
light
its
significance
applications
advancing
medical
diagnostics
reduce
burden
hospitals
save
human
lives.
Frontiers in Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: May 18, 2023
Background
Silymarin
is
a
polyphenolic
flavonoid
complex
extricated
from
dried
fruits
and
seeds
of
the
plant
Silybum
marianum
L.
Chemically,
it
mixture
flavonolignan
complexes
consisting
silybin,
isosilybin,
silychristin,
silydianin,
minor
quantity
taxifolin,
other
compounds,
which
possess
different
bio
medicinal
values.
Purpose
This
review
critically
looks
into
current
status,
pharmaceutical
prospects
limitations
clinical
application
for
treating
neurological
disorders.
In
particular,
Silymarin’s
properties
molecular
mechanisms
are
focused
on
providing
better-compiled
understanding
helpful
in
its
neuro-pharmacological
or
therapeutic
aspects.
Methods
was
compiled
by
literature
search
done
using
three
databases,
i.e.,
PubMed
(Medline),
EMBASE
Science
Direct,
up
to
January
2023,
keywords-Silymarin,
disorders,
cognitive
Type
2
Diabetes,
treatment.
Then,
potentially
relevant
publications
studies
(matching
eligible
criteria)
were
retrieved
selected
explain
this
PRISMA
2020
(Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses)
study
flow
chart.
Result
Since
discovery,
has
been
widely
studied
as
hepatoprotective
drug
various
liver
However,
last
10–15
years,
several
research
have
shown
putative
neuroprotective
nature
against
brain
including
psychiatric,
neurodegenerative,
cognitive,
metabolic
The
main
underlying
preventing
curing
such
disorders
antioxidant,
anti-inflammatory,
anti-apoptotic,
pro-neurotrophic
pro-estrogenic
bioactive
molecules.
Conclusion
provides
lucid
summary
well-studied
effects
Silymarin,
usage
during
Finally,
we
suggested
future
course
action
developing
novel
herbal
treatment
diseases.
Advanced Sensor Research,
Journal Year:
2023,
Volume and Issue:
3(3)
Published: Oct. 15, 2023
Abstract
Continuous
monitoring
of
physiological
parameters
has
remained
an
essential
component
patient
care.
With
increased
level
consciousness
regarding
personal
health
and
wellbeing,
the
scope
extended
beyond
hospital.
From
implanted
rhythm
devices
to
non‐contact
video
for
critically
ill
patients
at‐home
monitors
during
Covid‐19,
many
applications
have
enabled
continuous
monitorization.
Wearable
sensors
allowed
chronic
as
well
seemingly
healthy
individuals
track
a
wide
range
pharmacological
including
movement,
heart
rate,
blood
glucose,
sleep
patterns
using
smart
watches
or
textiles,
bracelets,
other
accessories.
The
use
metamaterials
in
wearable
sensor
design
offered
unique
control
over
electromagnetic,
mechanical,
acoustic,
optical,
thermal
properties
matter,
enabling
development
highly
sensitive,
user‐friendly,
lightweight
wearables.
However,
metamaterial
wearables
relied
heavily
on
manual
processes
human‐intuition‐based
bio‐inspired
design.
Artificial
intelligence
(AI)‐based
can
support
faster
exploration
parameters,
allow
efficient
analysis
large
data‐sets,
reduce
reliance
interventions,
facilitating
optimal
sensors.
Here,
AI‐based
healthcare
is
reviewed.
Current
challenges
future
directions
are
discussed.
Journal of The Electrochemical Society,
Journal Year:
2024,
Volume and Issue:
171(6), P. 067507 - 067507
Published: June 3, 2024
For
the
first
time,
a
green
ecofriendly
approach
is
applied,
to
develop
molecularly
imprinted
polymer
(MIP)
electrochemical
for
assay
of
oral
anti-viral
molnupiravir
(MLN)
in
various
matrices
as
confirmed
by
referring
analytical
eco-scale,
procedure
index
(GAPI),
Raynie
and
Driver,
greenness
metric
(AGREE),
national
environmental
(NEMI).
AuNPs
were
chronoamperometry
deposited
on
glassy
carbon
electrode
surface
(GCE)
using
0.01
gm
ml
−1
gold
solution
(HAuCl
4
.3H
2
O)
0.5
M
H
SO
at
constant
potential
−0.4
V
60
s.
Then,
MIP
was
created
electropolymerizing
O
PDA
GCE
cyclic
voltammetry
range
between
−0.5
+1
15
cycles
(scan
rate:
50
mV.s
).
To
optimize
sensor’s
performance,
factors
such
number
electropolymerization
cycles,
template:
monomer
ratio,
binding
rebinding
pH
buffer,
extraction
solvent,
deposition
time
Au
nanoparticles,
order
electrode;
surface,
well
differential
pulse
parameters
including
accumulation
step,
all
investigated.
The
detection
limit
set
0.00098
ng
(3
×
10
−12
M)
linearity
MLN
0.033
164
(1
−10
–5
−7
M).
sensor
employed
determination
its
pharmaceutical
product
(capsules),
spiked
human
plasma,
urine
samples
with
mean
recovery
%
±
relative
standard
deviation
(RSD)
(99.82%
0.53),
(99.88%
0.62),
(97.90%
0.70),
respectively.
investigated
provided
good
reproducibility,
repeatability,
durability.
Acceptable
selectivity
regarding
when
mixed
structurally
comparable
compounds
proved
RSD
(97.10%
0.03).
Additionally,
exposed
oxidative,
hydrolytic,
thermal
stress
conditions,
results
stability-indicating
studies
served
an
indicator
selectivity.
developed
coupled
portable
potentiostat,
making
it
promising
point-of-care
diagnostic
platform
on-site
measurements.
Journal of The Electrochemical Society,
Journal Year:
2025,
Volume and Issue:
172(1), P. 017510 - 017510
Published: Jan. 1, 2025
Glutamate
(Glu)
is
a
principal
neurotransmitter
owing
to
its
significant
function
in
physiological
and
pathological
processes.
Deviations
Glu
levels
have
been
associated
with
the
onset
of
various
neurological
disorders,
implicating
it
as
potential
biomarker
for
conditions
like
epilepsy,
stroke,
Alzheimer’s
disease,
amyotrophic
lateral
sclerosis.
Accurate
detection
essential
prevention,
diagnosis,
treatment
such
diseases.
Herein,
highly
sensitive
non-enzymatic
sensor
introduced
detect
Glu.
The
electrochemical
performance
was
studied
by
modifying
glassy
carbon
electrode
using
cobalt-based
metal-organic
framework/graphene
oxide
composite
(CoMG/GCE).
Differential
pulse
voltammetry
exhibited
linear
response
from
20.0
1.00
×
10
3
μM
at
an
alkali
solution
limit
3.10
μM.
DPV
utilized
determine
human
blood
serum
samples
standard
addition
method.
This
showed
lowest
interference
popular
species,
indicating
ability
healthcare
applications.
ECS Journal of Solid State Science and Technology,
Journal Year:
2022,
Volume and Issue:
11(12), P. 127003 - 127003
Published: Dec. 1, 2022
In
this
investigation,
a
new
class
of
polysaccharide
(cellulose
nanowhiskers
)
in
the
presence
manganese
oxide
nanoparticles
(MnO
2
NPs)
to
produce
hybrid
materials
was
synthesized
and
used
as
sensor
platform
with
high
fast
electrochemical
responses.
A
simple
method
synthesis
for
producing
different
cellulosic
nanostructures
has
been
evaluated
characterized
by
Fourier-transform
infrared
spectroscopy
(FTIR),
X-ray
diffraction
(XRD),
scanning
electron
microscope
(SEM),cyclic
voltammogram
(CV)
impedance
spectra
(EIS).
The
FTIR
analysis
data
approved
formation
cellulose
MnO
nanostructures.
uniform
distribution
nanostructure
over
surface
using
SEM.
addition,
From
CV
EIS
characterization
/Cellulose
have
electrocatalytic
properties
promising
applications
biosensors
non-enzymatic
sensors
fields.
/cellulose
hydrogen
peroxide
choronoamperometric
detection
sensitivity
0.70
μ
M
−1
,
linear
concentration
range
from
0.2
−
400
M,
lower
limit
(LOD)
0.04
(S/N
=
3)
R
0.98.
real
samples
percentage
recovery
93
110
%.
