Syndecan-1 As a Clinical Marker of Fluid Overload and Acute Kidney Injury

Pediatric Critical Care Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

1Division of Pediatric Critical Care, University Utah, Salt Lake City, UT. 2Cardiac Intensive Care Unit, Intermountain Primary Children's Hospital, The authors have disclosed that they do not any potential conflicts interest.

Language: Английский

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Demonstration of the impact of COVID-19 on metabolic associated fatty liver disease by bioinformatics and system biology approach

Medicine, Journal Year: 2023, Volume and Issue: 102(35), P. e34570 - e34570

Published: Sept. 1, 2023

Severe coronavirus disease 2019 (COVID-19) has caused a great threat to human health. Metabolic associated fatty liver (MAFLD) is with high prevalence rate. Previous studies indicated that MAFLD led increased mortality and severe case rates of COVID-19 patients, but its mechanism remains unclear.This study analyzed the transcriptional profiles patients their respective healthy controls from perspectives bioinformatics systems biology explore underlying molecular mechanisms between 2 diseases. Specifically, gene expression were acquired omnibus datasets screened shared differentially expressed genes (DEGs). Gene ontology pathway function enrichment analysis performed for common DEGs reveal regulatory relationship Besides, hub extracted by constructing protein-protein interaction network DEGs. Based on these genes, we conducted microRNA/transcription factors-genes - predicted potential drugs treatment MAFLD.A total 3734 589 transcriptome data (GSE183229) (GSE196822), respectively, 80 identified MAFLD. Functional revealed involved in inflammatory reaction, immune response metabolic regulation. In addition, 10 including SERPINE1, IL1RN, THBS1, TNFAIP6, GADD45B, TNFRSF12A, PLA2G7, PTGES, PTX3 GADD45G identified. From analysis, 41 transcription factors 151 micro-RNAs found be signals. Some mental, Inflammatory, diseases most related genes. Importantly, parthenolide, luteolin, apigenin MS-275 have shown possibility as therapeutic agents against MAFLD.This reveals pathogenesis COVID-19, providing novel clues future research acute respiratory syndrome infection.

Language: Английский

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Syndecan-3 inhibits LPS-induced Inflammation of Bovine Mammary Epithelial Cells through the NF-κB Signal Transduction Pathway

Journal of Dairy Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Identification of dynamic gene expression profiles during sequential vaccination with ChAdOx1/BNT162b2 using machine learning methods

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: March 17, 2023

To date, COVID-19 remains a serious global public health problem. Vaccination against SARS-CoV-2 has been adopted by many countries as an effective coping strategy. The strength of the body's immune response in face viral infection correlates with number vaccinations and duration vaccination. In this study, we aimed to identify specific genes that may trigger control under different vaccination scenarios. A machine learning-based approach was designed analyze blood transcriptomes 161 individuals who were classified into six groups according dose timing inoculations, including I-D0, I-D2-4, I-D7 (day 0, days 2-4, day 7 after first ChAdOx1, respectively) II-D0, II-D1-4, II-D7-10 1-4, 7-10 second BNT162b2, respectively). Each sample represented expression levels 26,364 genes. whereas mainly BNT162b2 (Only four received ChAdOx1). deemed labels considered features. Several learning algorithms employed such classification detail, five feature ranking (Lasso, LightGBM, MCFS, mRMR, PFI) applied evaluate importance each gene feature, resulting lists. Then, lists put incremental selection method extract essential genes, rules build optimal classifiers. namely, NRF2, RPRD1B, NEU3, SMC5, TPX2, have previously associated response. This study also summarized describe scenarios help determine molecular mechanism vaccine-induced antiviral immunity.

Language: Английский

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miR-19a-3p affected ox-LDL-induced SDC-1/TGF-β1/Smad3 pathway in atherosclerosis

Cellular and Molecular Biology, Journal Year: 2023, Volume and Issue: 69(3), P. 75 - 81

Published: March 31, 2023

Syndecan-1 (SDC-1) was a critical membrane proteoglycan and an important component of the glycocalyx in endothelial cells, but its role atherosclerosis remains unknown. This study attempted to investigate SDC-1 atherosclerotic-related cell injury. Bioinformatics analyzed differential miRNAs between healthy. Subjects with coronary atherosclerosis, which were diagnosed intravascular (IVUS), enrolled as non-vulnerable plaque vulnerable Changsha Central Hospital. Human aortic cells (HAECs) induced by oxidized low-density lipoprotein (ox-LDL) construct vitro model. A dual luciferase reporter assay applied analyze target miR-19a-3p SDC-1. The proliferation apoptosis detected CCK8 flow cytometry, respectively. cholesterol efflux determined ELISA. expression ATP-binding cassette (ABC) transports A1 (ABCA1), miR-19a-3p, ABCG1 genes RT-qPCR. expressions SDC-1, ABCA1, ABCG1, TGF-β1, Smad3 p-Smad3 proteins western blot. Our results found that down-regulated atherosclerosis. ox-LDL decreased expression, increased HAECs. Vulnerable tissues patients showed palpable fibrous necrosis calcification elevated blood levels. could bind Overexpression promoted proliferation, inhibited efflux, TGF-β1 ox-LDL-induced In conclusion, targeting activation TGF-β1/Smad3 pathway

Language: Английский

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Syndecan-1: a key player in health and disease

Immunogenetics, Journal Year: 2024, Volume and Issue: 77(1)

Published: Dec. 17, 2024

Language: Английский

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Syndecan-1: A Novel Diagnostic and Therapeutic Target in Liver Diseases

Current Drug Targets, Journal Year: 2023, Volume and Issue: 24(15), P. 1155 - 1165

Published: Nov. 1, 2023

Abstract: Syndecan-1 (SDC-1), known as a coreceptor of various growth factors or an integrin binding partner, regulates cell behaviours. Under certain pathological conditions, SDC-1 is shed from the surface and plays protective pathogenic role in diseases. In liver, highly expressed hepatocytes, where it localized on basolateral surface. It critical to cellular molecular functions including their attachment hepatitis viruses. Previous studies have reported that may function novel promising diagnostic therapeutic marker for liver diseases, such drug-induced injury, fibrosis, cancer. this review, we summarize related research highlight mechanisms by which participates pathogenesis well its potential applications. This review expected lay foundation further strategies target

Language: Английский

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AS03-adjuvanted H5N1 vaccine enhances immune response by modulating NR4A1, SDC1, ID3 genes, and reducing cortisol

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: Nov. 21, 2024

The AS03-adjuvanted H5N1 influenza vaccine induces significantly higher immune responses compared to the non-adjuvanted vaccine. However, immunological mechanisms underlying this enhancement remain unclear. We aimed identify key genes and pathways involved in response expression profiles of GSE102012 GSE112293 were downloaded from Gene Expression Omnibus database differentially expressed between groups. Subsequently, Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses performed using Database for Annotation, Visualization, Integrated Discovery online tool. protein–protein interaction (PPI) networks constructed by Search Tool Retrieval Interacting database. Through cluster analysis PPI network, three hub genes, namely NR4A1, SDC1, ID3, identified as pivotal players intricate network interactions. ID3 was up-regulated, other two down-regulated. results GO highlighted seven biological processes, cellular components, molecular functions among genes. KEGG revealed involvement Cushing syndrome pathway. may enhance through suppressing NR4A1 gene SDC1 gene, upregulating reducing cortisol production

Language: Английский

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Kistik Ekinokokkozlu Koyun Karaciğerlerinde Sindekan-1’in İmmünohistokimyasal Değişiklikleri

Harran Üniversitesi Veteriner Fakültesi Dergisi, Journal Year: 2023, Volume and Issue: 12(2), P. 141 - 145

Published: Sept. 5, 2023

Cystic echinococcosis is formed by the larval forms of Echinococcus granulosus, causes health problems in humans and different species animals worldwide. There still limited information about pathophysiological response to cystic liver. Syndecan-1 (Sdc1) a cell surface proteoglycan It has crucial role pathophysiology various liver diseases. This study aimed investigate immunohistochemical expression Sdc1 with sheep. A total number 51 tissue samples ten healthy livers were examined. The stained hematoxylin-eosin (HE) for histopathological examinations. was determined same tissues immunohistochemistry. Infected mainly showed severe inflammatory reactions, congestion, diffuse degeneration, necrosis hepatocytes around cysts. results indicated Sdc1-positive staining Liver control group relatively mild immunopositive reactions. that significantly increased sheep infection.

Language: Английский

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Evaluation of the level of IL-2 in the HCV patients in the Thi Qar Province Southern Iraq

AIP conference proceedings, Journal Year: 2023, Volume and Issue: 2899, P. 020017 - 020017

Published: Jan. 1, 2023

Language: Английский

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