Protective Effects of Chitosan Oligosaccharide Against Lipopolysaccharide-Induced Inflammatory Response and Oxidative Stress in Bovine Mammary Epithelial Cells

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(1), P. 31 - 31

Published: Jan. 9, 2025

Chitosan oligosaccharide (COS) is receiving increasing attention as a feed additive in animal production. COS has variety of biological functions, including anti-inflammatory and antioxidant activities. Mastitis major disease dairy cows that significant impact on welfare Hence, this research aimed to investigate the mechanism lipopolysaccharide (LPS)-stimulated inflammatory response oxidative stress bovine mammary epithelial cells (BMECs). In study, results demonstrated protected BMECs from induced by LPS restraining excessive production toll-like receptor 4 (TLR4), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β). treatment also suppressed reactive oxygen species (ROS) restored enzyme activity under LPS-induced conditions. Furthermore, promote nuclear factor erythroid 2-related 2 (Nrf2) expression inhibit TLR4 levels p65 IκBα phosphorylation exposed LPS. summary, demonstrate protective depend TLR4/nuclear factor-κB (NF-κB) Nrf2 signaling pathways, indicating could serve natural agents for alleviating mastitis.

Language: Английский

Experimental and clinical perspectives on glycocalyx integrity and its relation to acute respiratory distress syndrome

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: 1871(4), P. 167745 - 167745

Published: Feb. 22, 2025

Language: Английский