Using different zebrafish models to explore liver regeneration DOI Creative Commons

Dashuang Mo,

Mengzhu Lv,

Xiaoyu Mao

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 31, 2024

The liver possesses an impressive capability to regenerate following various injuries. Given its profound implications for the treatment of diseases, which afflict millions globally, regeneration stands as a pivotal area digestive organ research. Zebrafish (

Language: Английский

Quercetin, a natural flavonoid, protects against hepatic ischemia–reperfusion injury via inhibiting Caspase-8/ASC dependent macrophage pyroptosis DOI Creative Commons
Jiacheng Lin, Fuyang Li,

Junzhe Jiao

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Hepatic ischemia–reperfusion injury (IRI) is an inevitable adverse event following liver surgery, leading to damage and potential organ failure. Despite advancements, effective interventions for hepatic IRI remain elusive, posing a significant clinical challenge. The innate immune response significantly contributes the pathogenesis of by promoting inflammatory cytotoxic cycle. We have reported that blocking GSDMD-induced pyroptosis in immunity cells protected from injury. However, search inhibitors continues. This study aims evaluate whether quercetin, natural flavonoid, can inhibit mitigate IRI. established murine model cellular efficacy quercetin. Quercetin effectively alleviated IRI-induced tissue necrosis inflammation. found during IRI, cleavage GSDMD occurred macrophages, but not other non-parenchymal cells. inhibited macrophages. Moreover, we quercetin blocked ASC assembly formation NLRP3 inflammasomes AIM2 inflammasomes, suppressing macrophage pyroptosis. Co-immunoprecipitation experiments confirmed interaction between Caspase-8, which mechanism complex inflammasome formation. Overexpression Caspase-8 abolished anti-pyroptosis effect signaling. Furthermore, hepatoprotective activity was reduced myelocytic GSDMD-deficient mice. Our findings suggest has beneficial effects on could attenuate target inhibition via Caspase-8/ASC interaction. recommend might serve as targeted approach prevention personalized treatment perioperative patients.

Language: Английский

Citations

15
Hepatic Nonparenchymal Cells and Liver-Associated Lymphoid Cells DOI
Carol R. Gardner, Jeffrey D. Laskin, Debra L. Laskin

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Necrotic Liver Lesion Resolution: Another Mode of Liver Regeneration DOI

Cheng Chen,

Dechun Feng, Yang Wang

et al.

Seminars in Liver Disease, Journal Year: 2024, Volume and Issue: 44(03), P. 333 - 342

Published: July 2, 2024

The liver has the great ability to regenerate after partial resection or injury, and mechanisms underlying regeneration have been extensively investigated. Interestingly, acute injuries triggered by various etiologies are associated with formation of necrotic lesions, such lesions also rapidly resolved. However, how repaired not carefully investigated until recently. In this review, we briefly summarize spatiotemporal process lesion resolution in several injury models including immune-mediated drug-induced injury. roles nonparenchymal cells infiltrating immune controlling discussed, which may help identify potential therapies for failure.

Language: Английский

Citations

2
Using different zebrafish models to explore liver regeneration DOI Creative Commons

Dashuang Mo,

Mengzhu Lv,

Xiaoyu Mao

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 31, 2024

The liver possesses an impressive capability to regenerate following various injuries. Given its profound implications for the treatment of diseases, which afflict millions globally, regeneration stands as a pivotal area digestive organ research. Zebrafish (

Language: Английский

Citations

0