Unlocking the potential of Extracellular Vesicles in Nephrology – what does MISEV2023 add? DOI Creative Commons
Monica Suet Ying Ng, Dylan Burger, Per Svenningsen

et al.

Kidney International, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Extracellular vesicles, small membrane-bound packages secreted by virtually all cells of the body, have become a focus interest in Nephrology over recent years. After first characterization their proteomic and transcriptomic content, scientific attention shifted towards potential as biomarkers for kidney diseases both diagnostic monitoring tools. More recently, researchers begun exploring whether extracellular vesicles mediate intercellular signaling inside nephron between other organs throughout body. Nevertheless, field vesicle research has struggled to translate major findings clinical context due numerous methods separate yielding fractions different sizes varying purity, unclear terminology, and, hence, limitations concerning reproducibility. The International Society Vesicles, therefore, striven reduce these barriers an ongoing initiative increase rigor standardization research. "Minimal information studies vesicles" MISEV-guideline is result this its now 3rd iteration, provides most concise suggestions investigating date. This mini review illustrates advances made nephrology so far using informative examples, outlines former MISEV guidelines what utilizing latest iteration holds.

Language: Английский

Emerging Frontiers in acute kidney injury: The role of extracellular vesicles DOI
Sirui Li, Lan Zhou, Yu Huang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 149 - 170

Published: Feb. 18, 2025

Language: Английский

Citations

1
Emerging roles of exosomes in the diagnosis and treatment of kidney diseases DOI Creative Commons

Huanhuan Cao,

Zhenhong Li,

Jiajia Ye

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

The complex etiology and spectrum of kidney diseases necessitate vigilant attention; the focus on early diagnosis intervention in remains a critical issue medical research. Recently, with expanding studies extracellular vesicles, exosomes have garnered increasing interest as promising tool for treatment diseases. Exosomes are nano-sized vesicles that transport diverse array bioactive substances, which can influence various pathological processes associated exhibit detrimental or beneficial effects. Within kidney, derived from glomeruli renal tubules possess ability to enter systemic circulation urine. biomarkers they carry reflect alterations state kidneys, thereby offering novel avenues diagnosis. Furthermore, research confirmed originating multiple cell types therapeutic potential treating disease; notably, those mesenchymal stem cells (MSCs) shown significant efficacy. This comprehensive review summarizes contributions different within kidneys while exploring their physiological roles therein. Additionally, we emphasize recent advancements exosome applications forms over past decades. We not only introduce urinary blood linked found but also explore Finally, discuss existing challenges future directions concerning clinical diagnostic purposes.

Language: Английский

Citations

0
Consumption of poly-γ-glutamate-vitamin B6 supplement and urinary microbiota profiles in Korean healthy adults: a randomized, double-blinded, placebo-controlled intervention study DOI Open Access
Jungmin Park, Inkyung Baik

Nutrition Research and Practice, Journal Year: 2024, Volume and Issue: 18(5), P. 663 - 663

Published: Jan. 1, 2024

Poly-γ-glutamic acid (γ-PGA), a natural polymer found in fermented soybean products, has been reported to play prebiotic role the gut. This intervention study investigated effects of γ-PGA-containing supplement consumption on urinary microbiota healthy adults because limited data such investigation.

Language: Английский

Citations

2
Extracellular vesicles: Function, resilience, biomarker, bioengineering, and clinical implications DOI Creative Commons
Der‐Shan Sun, Hsin‐Hou Chang

Tzu Chi Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: May 24, 2024

Extracellular vesicles (EVs) have emerged as key players in intercellular communication, disease pathology, and therapeutic innovation. Initially overlooked cellular debris, EVs are now recognized vital mediators of cell-to-cell ferrying a cargo proteins, nucleic acids, lipids, providing resilience response to stresses. This review provides comprehensive overview EVs, focusing on their role biomarkers diagnosis, functional significance physiological pathological processes, the potential bioengineering for applications. offer promising avenue noninvasive diagnosis monitoring, reflecting state originating cells. Their diagnostic spans spectrum diseases, including cancer, cardiovascular disorders, neurodegenerative infectious diseases. Moreover, presence bodily fluids such blood, urine, cerebrospinal fluid enhances utility, presenting advantages over traditional methods. Beyond diagnostics, mediate crucial roles facilitating transfer bioactive molecules between communication modulates various processes tissue regeneration, immune modulation, neuronal communication. Dysregulation EV-mediated is implicated diseases highlighting potential. Bioengineering techniques avenues manipulating applications, from isolation purification engineering targeted delivery systems. These approaches hold promise developing novel therapeutics tailored specific revolutionizing personalized medicine. However, challenges standardization, scalability, regulatory approval need addressing successful clinical translation. Overall, represent dynamic frontier biomedical research with vast therapeutics,

Language: Английский

Citations

1
Extracellular vesicles: Illuminating renal pathophysiology and therapeutic frontiers DOI
L B Shi,

Houcheng Zeng,

Zhongwu An

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 978, P. 176720 - 176720

Published: June 15, 2024

Language: Английский

Citations

1
Is Vesicular Therapy the Newcomer That Matters for the Medicine of Tomorrow? DOI Open Access
Émilie Velot, Arnaud Bianchi

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3530 - 3530

Published: March 20, 2024

Extracellular vesicles (EVs) are membrane-enclosed particles released by cells into their extracellular environment [...].

Language: Английский

Citations

0
Biology of the proximal tubule in body homeostasis and kidney disease DOI
Melanie P. Hoenig, Craig R. Brooks, Ewout J. Hoorn

et al.

Nephrology Dialysis Transplantation, Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

The proximal tubule (PT) is known as the workhorse of kidney, both for range and magnitude functions that it performs. It not only responsible reabsorbing most solutes proteins filtered by glomeruli, but also secreting non-filtered substances including drugs uremic toxins. PT therefore plays a pivotal role in kidney physiology body homeostasis. Moreover, major site damage acute injury nephrotoxicity. In this review, we will provide an introduction to cell biology explore how adapted execution myriad different these can differ between males females. We then discuss regulates phosphate, glucose acid-base balance, consequences alterations function bone cardiovascular health. Finally, why vulnerable ischemic toxic insults, lead maladaptive repair, chronic damage, fibrosis. summary, demonstrate knowledge basic critical understanding disease phenotypes their associated systemic complications, developing new therapeutic strategies prevent these.

Language: Английский

Citations

0
Modeling a biofluid-derived extracellular vesicle surface signature to differentiate pediatric idiopathic nephrotic syndrome clinical subgroups DOI Creative Commons
Giulia Cricrì, Andrea Gobbini, Stefania Bruno

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 28, 2024

Idiopathic Nephrotic Syndrome (INS) is a common childhood glomerular disease requiring intense immunosuppressive drug treatments. Prediction of treatment response and the occurrence relapses remains challenging. Biofluid-derived extracellular vesicles (EVs) may serve as novel liquid biopsies for INS classification monitoring. Our cohort was composed 105 children at different clinical time points (onset, relapse, persistent proteinuria, remission, respectively), 19 healthy controls. The expression 37 surface EV markers evaluated by flow cytometry in serum (n = 83) urine 74) from (mean age 10.1, 58% males) points. Urine EVs 7) 11) age-matched 7.8, 94% were also analyzed. Tetraspanin enhanced during active phase respect to remission group positively correlates with proteinuria levels. Unsupervised clustering analysis identified an signature 8 related immunity angiogenesis/adhesion processes. CD41b, CD29, CD105 showed best diagnostic scores separating condition. Interestingly, combining urinary same patient improved precision staging separation. Three biomarkers (CD19, CD44, CD8) able classify based on steroid sensitivity. Biofluid offer non-invasive tool subclassification "personalized" interventions.

Language: Английский

Citations

0
Unlocking the potential of Extracellular Vesicles in Nephrology – what does MISEV2023 add? DOI Creative Commons
Monica Suet Ying Ng, Dylan Burger, Per Svenningsen

et al.

Kidney International, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Extracellular vesicles, small membrane-bound packages secreted by virtually all cells of the body, have become a focus interest in Nephrology over recent years. After first characterization their proteomic and transcriptomic content, scientific attention shifted towards potential as biomarkers for kidney diseases both diagnostic monitoring tools. More recently, researchers begun exploring whether extracellular vesicles mediate intercellular signaling inside nephron between other organs throughout body. Nevertheless, field vesicle research has struggled to translate major findings clinical context due numerous methods separate yielding fractions different sizes varying purity, unclear terminology, and, hence, limitations concerning reproducibility. The International Society Vesicles, therefore, striven reduce these barriers an ongoing initiative increase rigor standardization research. "Minimal information studies vesicles" MISEV-guideline is result this its now 3rd iteration, provides most concise suggestions investigating date. This mini review illustrates advances made nephrology so far using informative examples, outlines former MISEV guidelines what utilizing latest iteration holds.

Language: Английский

Citations

0