Supplementation of Miso to a Western-Type Diet Stimulates ILC3s and Decreases Inflammation in the Small Intestine DOI Open Access

River Budau,

Takuro Okamura, Yuka Hasegawa

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3743 - 3743

Published: Oct. 31, 2024

Western-type diets (WDs) damage the intestinal barrier by disrupting gut microbiota composition and causing inflammation, leading to development of obesity, type 2 diabetes, non-alcoholic fatty liver disease. Short-chain acids (SCFAs) are produced found in fermented foods can stimulate anti-inflammatory action 3 innate lymphoid cells (ILCS3s) intestine. This study hypothesised that supplementing miso, a Japanese food, WD could increase levels SCFAs thus ILC3s, decreasing inflammation intestine protecting integrity.

Language: Английский

Poly-γ-glutamic acid alleviates slow transit constipation by regulating aquaporin and gut microbes DOI Creative Commons
Xiaoru Wang, Jie Zhou, Zhang‐Hua Sun

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 10, 2025

Slow transit constipation (STC) is a prevalent gastrointestinal disorder caused by colon dysfunction. Poly-γ-glutamic acid (γ-PGA), an anionic polymer known for its moisture retention, degradability, and food safety, was studied effects on loperamide-induced STC in mice. Treatment with γ-PGA one week significantly increased both defecation frequency fecal water content, the high-dose group (10 g/kg/d) restoring content to 34.23%, outperforming low- (16.16%) medium-dose (27.08%) groups exceeding positive control, PEG, 1.35 times. enhanced intestinal peristalsis reduced expression of inflammatory markers (IL-1β, IL-6, caspase-1, TLR2) water-electrolyte transport genes (AQP3, AQP4, ENaC-β), while improving tight junction proteins (Claudin-1, Occludin, ZO-1) damaged loperamide. Histopathological analyses confirmed γ-PGA's capacity repair damage. Additionally, Western Blot analysis indicated AQP3/4 levels colon, molecular docking showed good binding affinity between AQPs. also positively altered gut microbiota composition. Overall, shows promise treating modulating aquaporins microbiota.

Language: Английский

Citations

0
Supplementation of Miso to a Western-Type Diet Stimulates ILC3s and Decreases Inflammation in the Small Intestine DOI Open Access

River Budau,

Takuro Okamura, Yuka Hasegawa

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3743 - 3743

Published: Oct. 31, 2024

Western-type diets (WDs) damage the intestinal barrier by disrupting gut microbiota composition and causing inflammation, leading to development of obesity, type 2 diabetes, non-alcoholic fatty liver disease. Short-chain acids (SCFAs) are produced found in fermented foods can stimulate anti-inflammatory action 3 innate lymphoid cells (ILCS3s) intestine. This study hypothesised that supplementing miso, a Japanese food, WD could increase levels SCFAs thus ILC3s, decreasing inflammation intestine protecting integrity.

Language: Английский

Citations

1