Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(11), P. 3033 - 3033
Published: Nov. 12, 2023
Chronic
kidney
disease
(CKD)
is
a
severe
condition
and
significant
public
health
issue
worldwide,
carrying
the
burden
of
an
increased
risk
cardiovascular
events
mortality.
The
traditional
factors
that
promote
onset
progression
CKD
are
cardiometabolic
like
hypertension
diabetes,
but
non-traditional
contributors
escalating.
Moreover,
gut
dysbiosis,
inflammation,
impaired
immune
response
emerging
as
crucial
mechanisms
in
pathology.
microbiome
exert
reciprocal
influence
commonly
referred
to
"the
gut-kidney
axis"
through
induction
metabolic,
immunological,
endocrine
alterations.
Periodontal
diseases
strictly
involved
axis
for
their
impact
on
microbiota
composition
metabolic
immunological
alterations
occurring
reciprocally
affecting
both
conditions.
This
review
aims
provide
overview
dynamic
biological
interconnections
between
oral
status,
gut,
renal
pathophysiology,
spotlighting
oral-gut-kidney
raising
whether
periodontal
can
be
modifiers
CKD.
By
doing
so,
we
try
offer
new
insights
into
therapeutic
strategies
may
enhance
clinical
trajectory
patients,
ultimately
advancing
our
quest
improved
patient
outcomes
well-being.
Nature Medicine,
Journal Year:
2024,
Volume and Issue:
30(7), P. 2058 - 2066
Published: May 25, 2024
Abstract
The
SELECT
trial
previously
reported
a
20%
reduction
in
major
adverse
cardiovascular
events
with
semaglutide
(
n
=
8,803)
versus
placebo
8,801)
patients
overweight/obesity
and
established
disease,
without
diabetes.
In
the
present
study,
we
examined
effect
of
once-weekly
2.4
mg
on
kidney
outcomes
trial.
incidence
pre-specified
main
composite
endpoint
(death
from
initiation
chronic
replacement
therapy,
onset
persistent
estimated
glomerular
filtration
rate
(eGFR)
<
15
ml
min
−1
1.73
m
−
2
,
≥50%
eGFR
or
macroalbuminuria)
was
lower
(1.8%)
(2.2%):
hazard
ratio
(HR)
0.78;
95%
confidence
interval
(CI)
0.63,
0.96;
P
0.02.
treatment
benefit
at
104
weeks
for
0.75
(95%
CI
0.43,
1.06;
0.001)
overall
2.19
1.00,
3.38;
baseline
<60
.
These
results
suggest
individuals
overweight/obesity,
ClinicalTrials.gov
identifier:
NCT03574597
Journal of the American Society of Nephrology,
Journal Year:
2012,
Volume and Issue:
23(8), P. 1351 - 1363
Published: July 6, 2012
Podocyte
depletion
leads
to
glomerulosclerosis,
but
whether
an
impaired
capacity
of
podocytes
respond
hypertrophic
stress
also
causes
glomerulosclerosis
is
unknown.
We
generated
transgenic
Fischer
344
rats
that
express
a
dominant
negative
AA-4E-BP1
transgene
driven
by
the
podocin
promoter;
member
mammalian
target
rapamycin
complex
1
(mTORC1)
pathway,
4E-BP1
modulates
cap-dependent
translation,
which
key
determinant
cell’s
response
nutrients
and
growth
factors.
rat
expressed
had
normal
kidney
histology
protein
excretion
at
100
g
body
weight
developed
ESRD
12
months.
Proteinuria
were
linearly
related
both
increasing
dose.
Uni-nephrectomy
reduced
proteinuria
first
40%–50%.
The
initial
histologic
manifestation
disease
was
appearance
bare
areas
glomerular
basement
membrane
from
pulling
apart
podocyte
foot
processes,
followed
adhesions
Bowman
capsule.
Morphometric
analysis
confirmed
mismatch
between
tuft
volume
total
(number
×
size)
per
in
relation
gain
nephrectomy.
did
not
develop
if
dietary
calorie
restriction
prevented
enlargement.
In
summary,
failure
match
signaling
through
mTORC1
pathway
can
trigger
proteinuria,
progression
ESRD.
Reducing
may
be
useful
adjunctive
therapies
slow
or
prevent
Scientifica,
Journal Year:
2014,
Volume and Issue:
2014, P. 1 - 9
Published: Jan. 1, 2014
Skipping
breakfast
is
considered
to
be
an
unhealthy
eating
habit
linked
predispositions
obesity
and
type
2
diabetes.
Because
dinner
late
at
night
can
elicit
subsequent
skipping,
we
investigated
if
skipping
concomitant
with
late-night-dinner
(LNDE)
was
associated
metabolic
syndrome
(MetS)
proteinuria
in
the
general
Japanese
population.
We
examined
self-reported
habitual
LNDE,
MetS
(modified
ATP-III
criteria),
a
cross-sectional
study
of
60,800
adults
aged
20–75
years.
A
total
14,068
subjects
(23.1%)
skipped
breakfast,
whom
approximately
half
(52.8%)
alone
(without
LNDE).
The
percentages
who
showed
J-shaped
relationship
body
mass
index
(BMI).
Multivariate
logistic
regression
analysis
that
LNDE
(n=
6,645)
significantly
proteinuria,
even
after
adjusting
for
relevant
confounders
(odds
ratio
(95%
CI),
1.17
(1.08–1.28),P=0.0003,
1.37
(1.24–1.52),P<0.0001,
resp.).
were
not
respectively.
In
conclusion,
may
represent
poorer
behavior
than
alone,
MetS,
asymptomatic
obesity,
low
weight
Electrolytes & Blood Pressure,
Journal Year:
2013,
Volume and Issue:
11(2), P. 46 - 46
Published: Jan. 1, 2013
With
excess
nutrition,
the
burden
of
obesity
is
a
growing
problem
worldwide.
The
imbalance
between
energy
intake
and
expenditure
leads
to
variable
disorders
as
all
major
risk
factors
for
cardiovascular
disease.
There
are
many
hypothetical
mechanisms
explain
obesity-associated
hypertension.
Activation
RAAS
key
contributing
factor
in
obesity.
Particularly,
adipose
tissue
plays
crucial
role
dysfunction
obesity-induced
inflammation.
phenotypic
changes
adipocytes
occur
into
hypertrophy
an
inflammatory
response
autocrine
paracrine
manner
impair
adipocyte
function,
including
insulin
signaling
pathway.
Adipose
produce
secretes
several
molecules
such
leptin,
resistin,
adiponectin,
visfatin,
well
cytokines
TNF-α,
IL-6,
MCP-1,
IL-1.
These
adipokines
stimulated
via
intracellular
pathways
that
regulate
inflammation
tissue.
Inflammation
oxidative
stress
important
interact
with
microvascular
endothelium
Increased
resistance
raises
blood
pressure.
Therefore,
regulatory
link
perivascular
adipokine
synthesis
provided
mechanism
Canadian Journal of Physiology and Pharmacology,
Journal Year:
2014,
Volume and Issue:
92(9), P. 717 - 724
Published: June 16, 2014
The
most
important
reason
for
the
non-approval
and
withdrawal
of
drugs
by
Food
Drug
Administration
is
hepatotoxicity.
Therefore,
this
study
was
undertaken
to
evaluate
protective
effects
hesperidin
against
cyclophosphamide
(CYP)-induced
hepatotoxicity
in
Wistar
rats.
rats
received
a
single
intraperitoneal
dose
CYP
200
mg/kg
body
mass,
followed
treatment
with
hesperidin,
orally,
at
doses
25
50
11
consecutive
days.
induced
hepatic
damage,
as
evidenced
significantly
elevated
levels
serum
pro-inflammatory
cytokines,
transaminases,
liver
lipid
peroxidation,
nitric
oxide.
As
consequence,
there
reduced
glutathione
content,
activities
antioxidant
enzymes
superoxide
dismutase,
catalase,
peroxidase,
were
markedly
reduced.
In
addition,
administration
considerable
downregulation
peroxisome
proliferator
activated
receptor
gamma
(PPARγ)
upregulation
nuclear
factor-kappa
B
(NF-κB)
inducible
oxide
synthase
(iNOS)
mRNA
expression.
Hesperidin,
dose-dependent
manner,
rejuvenated
altered
markers
an
almost
normal
state.
conclusion,
showed
potent
effect
CYP-induced
oxidative
stress
inflammation
leading
suggests
that
exerts
its
through
PPARγ
expression
abrogation
stress.
Diabetes & Metabolism,
Journal Year:
2023,
Volume and Issue:
50(1), P. 101506 - 101506
Published: Dec. 21, 2023
With
the
rising
tide
of
fatty
liver
disease
related
to
metabolic
dysfunction
worldwide,
association
this
common
with
chronic
kidney
(CKD)
has
become
increasingly
evident.
In
2020,
more
inclusive
term
dysfunction-associated
(MAFLD)
was
proposed
replace
old
nonalcoholic
(NAFLD).
2023,
a
modified
Delphi
process
led
by
three
large
pan-national
associations.
There
consensus
change
nomenclature
and
definition
include
presence
at
least
one
five
cardiometabolic
risk
factors
as
diagnostic
criteria.
The
name
chosen
NAFLD
steatotic
(MASLD).
from
MAFLD
then
MASLD
resulted
in
reappraisal
epidemiological
trends
associations
developing
CKD.
observed
between
MAFLD/MASLD
CKD
our
understanding
that
can
be
an
epiphenomenon
linked
underlying
support
notion
individuals
are
substantially
higher
incident
than
those
without
MASLD.
This
narrative
review
provides
overview
literature
on
(a)
evolution
criteria
for
diagnosing
highly
prevalent
disease,
(b)
evidence
linking
CKD,
(c)
mechanisms
which
(and
strongly
MASLD)
may
increase
(d)
potential
drug
treatments
benefit
both
