Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation

Journal of Cancer, Journal Year: 2016, Volume and Issue: 7(15), P. 2346 - 2359

Published: Jan. 1, 2016

Adipose tissue in addition to its ability keep lipids is now recognized as a real organ with both metabolic and endocrine functions.Recent studies demonstrated that obese animals established status of adipocyte hypoxia this hypoxic state interaction between adipocytes stromal vascular cells contribute tumor development progression.In several tumors such breast, colon, liver prostate, obesity represents poor predictor clinical outcomes.Dysfunctional adipose releases disturbed profile adipokines elevated levels pro-inflammatory factors consequent alteration key signaling mediators which may be an active local player establishing the peritumoral environment promoting growth progression.Therefore, might cancer risk population.To date precise mechanisms behind obesity-cancer link not yet fully understood.In light information provided review aims identify underlying we support inflammatory specific important link.

Language: Английский

---

An update on physical health and economic consequences of overweight and obesity

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2018, Volume and Issue: 12(6), P. 1095 - 1100

Published: May 5, 2018

Language: Английский

---

Probiotics for the Treatment of Overweight and Obesity in Humans—A Review of Clinical Trials

Microorganisms, Journal Year: 2020, Volume and Issue: 8(8), P. 1148 - 1148

Published: July 29, 2020

The World Health Organization (WHO) reports that 400 million people are obese, and over 1.6 billion adults overweight worldwide. Annually, 2.8 die from obesity-related diseases. incidence of obesity is steadily increasing, this phenomenon referred to as a 21st-century pandemic. main reason for an easy access high-energy, processed foods, low-activity lifestyle. These changes lead energy imbalance and, consequence, the development body fat. Weight gain contributes heart diseases, skeletal system disorders, metabolic disorders such diabetes, certain types cancer. In recent years, there have been many works linking with intestinal microbiota. Experiments on germ-free animals (GFs) provided much evidence contribution bacteria obesity. composition gut microbiota (GM) in obese people. affect degree obtained food, secretory functions adipose tissue, carbohydrate, lipid metabolism liver, activity centers brain. study aimed present current state knowledge about role impact supplementation probiotic health patients.

Language: Английский

---

Epicardial Fat: Physiological, Pathological, and Therapeutic Implications

Cardiology Research and Practice, Journal Year: 2016, Volume and Issue: 2016, P. 1 - 15

Published: Jan. 1, 2016

Epicardial fat is closely related to blood supply vessels, both anatomically and functionally, which why any change in this adipose tissue’s behavior considered a potential risk factor for cardiovascular disease development. When proinflammatory adipokines are released from the epicardial fat, can lead decrease insulin sensitivity, low adiponectin production, an increased proliferation of vascular smooth muscle cells. These move one compartment another by either transcellular passing or diffusion, thus having ability regulate cardiac activity, phenomenon called vasocrine regulation. The participation these generates state persistent vasoconstriction, stiffness, weakening coronary wall, consequently contributing formation atherosclerotic plaques. Therefore, tissue thickening should be development disease, therapeutic target pathology molecular point contact “endocrine-cardiology.”

Language: Английский

---

Celastrol suppresses obesity process via increasing antioxidant capacity and improving lipid metabolism

European Journal of Pharmacology, Journal Year: 2014, Volume and Issue: 744, P. 52 - 58

Published: Oct. 9, 2014

Language: Английский

---

Coffee consumption and risk of hypertension: a systematic review and dose–response meta-analysis of cohort studies

Journal of Human Hypertension, Journal Year: 2018, Volume and Issue: 32(2), P. 83 - 93

Published: Jan. 4, 2018

Language: Английский

---

Dietary Approaches to Stop Hypertension (DASH): potential mechanisms of action against risk factors of the metabolic syndrome

Nutrition Research Reviews, Journal Year: 2019, Volume and Issue: 33(1), P. 1 - 18

Published: July 30, 2019

Abstract The metabolic syndrome is a cluster of disorders dominated by abdominal obesity, hypertriacylglycerolaemia, low HDL-cholesterol, high blood pressure and fasting glucose. Diet modification safe effective way to treat the syndrome. Dietary Approaches Stop Hypertension (DASH) dietary pattern rich in fruits, vegetables low-fat dairy products, meats sweets. DASH provides good amounts fibre, K, Ca Mg, limited quantities total fat, saturated cholesterol Na. Although was initially designed for prevention or control hypertension, using diet has other benefits. In present review, effect each component on risk factors discussed. Due fat fibre content, individuals are less prone overweight obesity possess lower concentrations LDL-cholesterol although changes TAG HDL-cholesterol have been significant available evidence this regard still inconclusive. Moreover, fruit provide great Mg all which shown reduce pressure. antioxidants also correcting glucose insulin abnormalities. Evidence provided from cross-sectional investigations, cohort studies randomised controlled trials, and, where available, published meta-analyses. Mechanisms described according human case lack evidence, animal cell culture investigations.

Language: Английский

---

Obesity and its relation to depressive symptoms and sedentary lifestyle in middle-aged women

Maturitas, Journal Year: 2014, Volume and Issue: 80(1), P. 100 - 105

Published: Oct. 23, 2014

Language: Английский

---

Oligofructose decreases serum lipopolysaccharide and plasminogen activator inhibitor‐1 in adults with overweight/obesity

Obesity, Journal Year: 2017, Volume and Issue: 25(3), P. 510 - 513

Published: Feb. 23, 2017

Objective To determine the effect of prebiotic supplementation on metabolic endotoxemia and systemic inflammation in adults with overweight obesity. Methods Samples from a previously conducted randomized, double‐blind, placebo‐controlled trial were used for analysis. Participants randomized to 21 g oligofructose ( n = 20; BMI 30.4 kg/m 2 ) or maltodextrin placebo 17; 29.5 12 weeks. A total 37 participants had samples available current Resistin, adiponectin, plasminogen activator inhibitor‐1 (PAI‐1), interleukin‐6 (IL‐6), tumor necrosis factor‐α (TNF‐α), macrophage chemoattractant protein‐1 (MCP‐1) quantified using MILLIPLEX® assays. Lipopolysaccharide (LPS) was measured PyroGene™ Recombinant Factor C Assay. Results Plasma LPS concentrations reduced by 40% group over weeks compared 48% increase P 0.04). PAI‐1, risk factor thrombosis, greater extent (−17.3 ± 2.6 ng/ml) (−9.7 1.8 ng/ml; 0.03). Oligofructose did not affect IL‐6, TNF‐α, MCP‐1, resistin. Conclusions reduces PAI‐1. Incorporating prebiotics into diet through supplements functional foods may help mitigate some markers obesity‐associated inflammation.

Language: Английский

---

Modifiable risk factors associated with prediabetes in men and women: a cross-sectional analysis of the cohort study in primary health care on the evolution of patients with prediabetes (PREDAPS-Study)

BMC Family Practice, Journal Year: 2015, Volume and Issue: 16(1)

Published: Jan. 21, 2015

Prediabetes is a high-risk state for diabetes development, but little known about the factors associated with this state. The aim of study was to identify modifiable risk presence prediabetes in men and women. Cohort Study Primary Health Care on Evolution Patients (PREDAPS-Study) prospective cohort 1184 subjects another 838 without glucose metabolism disorders. It being conducted by 125 general practitioners Spain. Data analysis were collected during baseline stage 2012. included were: smoking habit, alcohol consumption, low physical activity, inadequate diet, hypertension, dyslipidemia, obesity. To assess independent association between each factor prediabetes, odds ratios (ORs) estimated using logistic regression models. Abdominal obesity, plasma levels high-density lipoprotein cholesterol (HDL-cholesterol), hypertension independently both After adjusting all factors, respective ORs (95% Confidence Intervals) 1.98 (1.41-2.79), 1.88 (1.23-2.88) 1.86 (1.39-2.51) men, 1.89 (1.36-2.62), 1.58 (1.12-2.23) 1.44 (1.07-1.92) Also, obesity sexes did not reach statistical significance among after factors. Risky consumption OR 1.49 (1.00-2.24). Obesity, HDL-cholesterol levels, related sexes. magnitudes associations stronger than women displayed strongest prediabetes. findings suggest that there are some differences women, which should be taken into account when implementing specific recommendations prevent or delay onset adult population.

Language: Английский

---