Infection, Dysbiosis and Inflammation Interplay in the COVID Era in Children

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10874 - 10874

Published: June 29, 2023

For over three years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children and adolescents has generated repercussions, especially a few weeks after infection, for symptomatic patients who tested positive, asymptomatic ones, or even just the contacts of an infected person, evolved from forms such as multisystem inflammatory (MIS-C) to multifarious clinical manifestations long COVID (LC). Referred under umbrella term LC, onset persistent highly heterogeneous symptoms fatigue, post-exertion malaise, cognitive dysfunction, others have major impact on child's daily quality life months. The first aim this review was highlight circumstances pathophysiological changes produced by COVID-19 better understand hyperinflammation how MIS-C, life-threatening condition, could been avoided some patients. Another goal identify interplay between dysbiosis, inflammation at molecular cellular level, guide scientists, physicians, pediatricians advance new lines medical action avoid post-acute sequelae SARS-CoV-2 infection. third objective their connection pathways recognize LC more easily. fourth purpose connect triggering factors with related following injuries systems organs, persistence virus, its components hidden reservoirs, including gut central nervous system. reactivation other latent infectious agents host's immune environments, interaction virus microbiome, hyperactivation, autoimmunity mimicry viral host proteins, initiate targeted individualized management. New high-tech solutions, molecules, probiotics, should be discovered innovatively solve RNA viruses, microbiota, our

Language: Английский

Update on Central Nervous System Effects of the Intersection of HIV-1 and SARS-CoV-2

Current HIV/AIDS Reports, Journal Year: 2023, Volume and Issue: 20(6), P. 345 - 356

Published: Nov. 11, 2023

Language: Английский

Effect of COVID-19 on the Gut Microbiota of Pregnant Women (review)

Epidemiology and Vaccinal Prevention, Journal Year: 2024, Volume and Issue: 23(5), P. 92 - 98

Published: Nov. 7, 2024

The Novel coronavirus infection (COVID-19) pandemic has shown that pregnant women are at risk for and severe COVID- 19. Pregnant often experience gastrointestinal symptoms both during the peak of disease within 90 days after recovery. This review is devoted to study effect SARS-CoV-2 virus on gut microbiota women. Since many studies confirm changes in composition COVID-19, dependence severity course microbiota, persistence question remains whether intestinal newborns it possible correct state dysbiosis COVID-19 with probiotics purpose prevention treatment newborns.

Language: Английский