Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord DOI Creative Commons
A Pazzaglia, Andrej Bičanski, Andrea Ferrario

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 28, 2024

Abstract This study introduces a novel neuromechanical model employing detailed spiking neural network to explore the role of axial proprioceptive sensory feedback, namely stretch in salamander locomotion. Unlike previous studies that often oversimplified dynamics locomotor networks, our includes simulations classes neurons are considered responsible for generating movement patterns. The circuits, modeled as adaptive leaky integrate-and-fire neurons, coupled three-dimensional mechanical with realistic physical parameters and simulated muscles. In open-loop (i.e., without feedback), replicates patterns observed in-vitro in-vivo swimming trotting gaits. Additionally, modular descending reticulospinal drive central pattern generation allows accurately control activation, frequency phase relationship different sections limb circuits. closed-loop (i.e. including systematic evaluations reveal intermediate values feedback strength increase tail beat reduce intersegmental lag, contributing more coordinated, faster energy-efficient Interestingly, result is conserved across topologies (ascending or descending, excitatory inhibitory), suggesting it may be an inherent property proprioception. Moreover, strengths expand stability region network, enhancing its tolerance wider range drives, internal parameters’ modifications noise levels. Conversely, high lead loss controllability degradation performance. Overall, this highlights beneficial proprioception generating, modulating stabilizing locomotion patterns, provided does not excessively override centrally-generated rhythms. work also underscores critical detailed, biologically-realistic networks improve understanding vertebrate Author summary paper, we developed computational investigate how salamanders move, both while walking. these complex integrates from body’s movements modulate Our suggest plays major controlling rhythm coordination movements. has implications only move but provides insights into evolution vertebrates. By investigating mechanisms interact produce efficient adaptable movement, contributes broader field neuroscience robotics, offering potential strategies designing effective biomimetic robots.

Language: Английский

Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord DOI Creative Commons
A Pazzaglia, Andrej Bičanski, Andrea Ferrario

et al.

PLoS Computational Biology, Journal Year: 2025, Volume and Issue: 21(1), P. e1012101 - e1012101

Published: Jan. 21, 2025

This study introduces a novel neuromechanical model employing detailed spiking neural network to explore the role of axial proprioceptive sensory feedback, namely stretch in salamander locomotion. Unlike previous studies that often oversimplified dynamics locomotor networks, our includes simulations classes neurons are considered responsible for generating movement patterns. The circuits, modeled as adaptive leaky integrate-and-fire neurons, coupled three-dimensional mechanical with realistic physical parameters and simulated muscles. In open-loop (i.e., without feedback), replicates patterns observed in-vitro in-vivo swimming trotting gaits. Additionally, modular descending reticulospinal drive central pattern generation allows accurately control activation, frequency phase relationship different sections limb circuits. closed-loop (i.e. including systematic evaluations reveal intermediate values feedback strength increase tail beat reduce intersegmental lag, contributing more coordinated, faster energy-efficient Interestingly, result is conserved across topologies (ascending or descending, excitatory inhibitory), suggesting it may be an inherent property proprioception. Moreover, strengths expand stability region network, enhancing its tolerance wider range drives, internal parameters’ modifications noise levels. Conversely, high lead loss controllability degradation performance. Overall, this highlights beneficial proprioception generating, modulating stabilizing locomotion patterns, provided does not excessively override centrally-generated rhythms. work also underscores critical detailed, biologically-realistic networks improve understanding vertebrate

Language: Английский

Citations

1
Degenerate Neuronal and Circuit Mechanisms Important for Generating Rhythmic Motor Patterns DOI
Ronald L. Calabrese, Eve Marder

Physiological Reviews, Journal Year: 2024, Volume and Issue: 105(1), P. 95 - 135

Published: June 13, 2024

In 1996, we published a review article (Marder E, Calabrese RL.

Language: Английский

Citations

6
Distinct anatomical and functional corticospinal inputs innervate different spinal neuron types DOI Creative Commons

Samaher Fageiry,

Claire L. Warriner, Jackson Loper

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

SUMMARY The corticospinal tract exerts its influence on movement through spinal neurons, which can be divided into types that exhibit distinct functions. However, it remains unknown whether these functional distinctions are reflected in the inputs different of neurons receive. Using rabies monosynaptic tracing from individual neuron cervical cord and 3D histological reconstruction mice, we discovered receive distinctly distributed across cortex, aligned with cell type function. This included a distinct, sparse distribution direct cortex onto motor neurons. Coupling activity measurement during behavior revealed interneuron input patterns, primarily due to topographical contacting them. Our results establish get anatomical reveal functionally relevant homology primate organization.

Language: Английский

Citations

4
Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns DOI Creative Commons

Andrea Juárez Tello,

Cornelis Immanuel van der Zouwen, Léonie Dejas

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(5), P. 114187 - 114187

Published: May 1, 2024

The locomotor role of dopaminergic neurons is traditionally attributed to their ascending projections the basal ganglia, which project mesencephalic region (MLR). In addition, descending MLR are present from vertebrates mammals. However, targeted in and behavioral unknown Here, we identify genetically defined cells that express D

Language: Английский

Citations

4
Manual assessment of cylinder rearing behavior is more sensitive than automated gait evaluations in young, male mice post-stroke of the forepaw somatosensory cortex DOI Creative Commons

Cynthia Li,

Esha Kapoor,

Wei Chen

et al.

Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 108325 - 108325

Published: April 1, 2025

Language: Английский

Citations

0
Mito-metformin protects against mitochondrial dysfunction and dopaminergic neuronal degeneration by activating upstream PKD1 signaling in cell culture and MitoPark animal models of Parkinson’s disease DOI Creative Commons
Muhammet Ay,

Adhithiya Charli,

Monica R. Langley

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Feb. 21, 2024

Impaired mitochondrial function and biogenesis have strongly been implicated in the pathogenesis of Parkinson’s disease (PD). Thus, identifying key signaling mechanisms regulating is crucial to developing new treatment strategies for PD. We previously reported that protein kinase D1 (PKD1) activation protects against neuronal cell death PD models by biogenesis. To further harness translational drug discovery potential targeting PKD1-mediated neuroprotective signaling, we synthesized mito-metformin (Mito-Met), a mitochondria-targeted analog derived from conjugating anti-diabetic metformin with triphenylphosphonium functional group, then evaluated preclinical efficacy Mito-Met culture MitoPark animal (100–300 nM) significantly activated PKD1 phosphorylation, as well downstream Akt AMPKα more potently than metformin, N27 dopaminergic cells. Furthermore, upregulated mRNA expression transcription factor A (TFAM) implying can promote Interestingly, increased bioenergetics capacity also reduced fragmentation induced Parkinsonian neurotoxicant MPP + cells protected -induced TH-positive neurite loss primary neurons. More importantly, (10 mg/kg, oral gavage 8 week) improved motor deficits striatal dopamine depletion mice. Taken together, our results demonstrate possesses profound effects both vitro vivo PD, suggesting pharmacological could be novel strategy other related neurocognitive diseases.

Language: Английский

Citations

3
Steering From the Rear: Coordination of Central Pattern Generators Underlying Navigation by Ascending Interneurons DOI Creative Commons
Julius Jonaitis, Karen L Hibbard,

Kaity McCafferty Layte

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 17, 2024

ABSTRACT Understanding how animals coordinate movements to achieve goals is a fundamental pursuit in neuroscience. Here we explore neurons that reside posterior lower-order regions of locomotor system project anterior higher-order influence steering and navigation. We characterized the anatomy functional role population ascending interneurons ventral nerve cord Drosophila larvae. Through electron microscopy reconstructions light microscopy, determined cholinergic 19f cells receive input primarily from premotor synapse upon diverse array postsynaptic targets within segments including other cells. Calcium imaging activity isolated central nervous (CNS) preparations relation motor revealed are recruited into most larval programmes. lags behind neuron as population, encode spatio-temporal patterns CNS. Optogenetic manipulations cell CNS they pattern generators underlying exploratory headsweeps forward locomotion context location specific manner. In behaving animals, activating suppressed slowed locomotion, while inhibition potentiated headsweeps, slowing movement. Inhibiting ultimately affected ability larvae remain vicinity an odor source during olfactory navigation task. Overall, our findings provide insights monitor shape interactions amongst rhythm complex navigational tasks.

Language: Английский

Citations

2
Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord DOI Creative Commons
A Pazzaglia, Andrej Bičanski, Andrea Ferrario

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 28, 2024

Abstract This study introduces a novel neuromechanical model employing detailed spiking neural network to explore the role of axial proprioceptive sensory feedback, namely stretch in salamander locomotion. Unlike previous studies that often oversimplified dynamics locomotor networks, our includes simulations classes neurons are considered responsible for generating movement patterns. The circuits, modeled as adaptive leaky integrate-and-fire neurons, coupled three-dimensional mechanical with realistic physical parameters and simulated muscles. In open-loop (i.e., without feedback), replicates patterns observed in-vitro in-vivo swimming trotting gaits. Additionally, modular descending reticulospinal drive central pattern generation allows accurately control activation, frequency phase relationship different sections limb circuits. closed-loop (i.e. including systematic evaluations reveal intermediate values feedback strength increase tail beat reduce intersegmental lag, contributing more coordinated, faster energy-efficient Interestingly, result is conserved across topologies (ascending or descending, excitatory inhibitory), suggesting it may be an inherent property proprioception. Moreover, strengths expand stability region network, enhancing its tolerance wider range drives, internal parameters’ modifications noise levels. Conversely, high lead loss controllability degradation performance. Overall, this highlights beneficial proprioception generating, modulating stabilizing locomotion patterns, provided does not excessively override centrally-generated rhythms. work also underscores critical detailed, biologically-realistic networks improve understanding vertebrate Author summary paper, we developed computational investigate how salamanders move, both while walking. these complex integrates from body’s movements modulate Our suggest plays major controlling rhythm coordination movements. has implications only move but provides insights into evolution vertebrates. By investigating mechanisms interact produce efficient adaptable movement, contributes broader field neuroscience robotics, offering potential strategies designing effective biomimetic robots.

Language: Английский

Citations

0