Biochemistry (Moscow), Journal Year: 2023, Volume and Issue: 88(12-13), P. 2007 - 2022
Published: Dec. 1, 2023
Language: Английский
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 292 - 292
Published: Feb. 19, 2024
Interindividual variability in drug response is a major problem the prescription of pharmacological treatments. The therapeutic effect drugs can be influenced by human genes. Pharmacogenomic guidelines for individualization treatment have been validated and used conventional dosage forms. However, often target non-specific areas produce both desired undesired effects. use nanoparticles, liposomes, or other available forms formulation could help to overcome latter problem. Virus-like particles based on retroviruses potential envelope safe efficient formulations. Human endogenous would make it possible host immune deliver target. PEG10 promising candidate that bind mRNA because secreted like an enveloped virus-like extracellular vesicle. retrotransposon-derived gene has domesticated. Therefore, formulations with may lower immunogenicity. existing knowledge lead development suitable precise individual diseases.
Language: Английский
Citations
4
Vaccines, Journal Year: 2025, Volume and Issue: 13(4), P. 415 - 415
Published: April 15, 2025
Human Endogenous Retroviruses comprise approximately 8% of the human genome, serving as fragments ancient retroviral infections. Although they are generally maintained in a silenced state by robust epigenetic mechanisms, specific HERV groups, particularly HERV-W and HERV-K, can become derepressed under pathological conditions, thereby contributing to initiation progression neuroinflammatory neurodegenerative processes. Preclinical studies clinical trials, such those investigating monoclonal antibodies, indicate that directly targeting these elements may offer novel therapeutic strategy. In this review, we provide an overview HERVs′ biology, examine their role diseases amyotrophic lateral sclerosis, multiple Alzheimer′s disease, Parkinson′s explore prospects, highlighting both challenges potential future research directions needed translate approaches into interventions.
Language: Английский
Citations
0
Genes, Journal Year: 2023, Volume and Issue: 14(12), P. 2150 - 2150
Published: Nov. 28, 2023
Human endogenous retroviruses (HERVs) comprise a significant portion of the human genome, making up roughly 8%, notable comparison to 2–3% represented by coding sequences. Numerous studies have underscored critical role and importance HERVs, highlighting their diverse extensive influence on evolution genome establishing complex correlation with various diseases. Among HERV-K (HML-2) subfamily has recently attracted attention, integrating into after divergence between humans chimpanzees. Its insertion in received considerable attention due its structural functional characteristics time insertion. Originating from ancient exogenous retroviruses, these elements succeeded infecting germ cells, enabling vertical transmission existing as proviruses within genome. Remarkably, sequences retained capacity form complete viral sequences, exhibiting activity transcription translation. The is subject active debate about potential positive or negative effects pathologies. This review summarizes variation, regulation, diseases arising (HML-2).
Language: Английский
Citations
7
Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e28163 - e28163
Published: March 1, 2024
BackgroundCurrent research on amniotic fluid (AF) microbiota yields contradictory data, necessitating an accurate, comprehensive, and scientifically rigorous evaluation.ObjectiveThis study aimed to characterise the microbial features of AF explore correlation between information clinical parameters.Methods76 samples were collected in this prospective cohort study. Fourteen utilised establish nanopore metagenomic sequencing methodology, whereas remaining 62 underwent a final statistical analysis along with information. Negative controls included operating room environment (OE), surgical instruments (SI), laboratory experimental processes (EP) elucidate background contamination at each step. Simultaneously, levels five cytokines (IL-1β, IL-6, IL-8, TNF-α, MMP-8) assessed.ResultsAmong samples, identified seven without microbes 55 low diversity abundance. No significant differences observed microbes. The parameters normal chromosomal structure revealed noteworthy findings. In particular, third trimester exhibited richer diversity. Pseudomonas demonstrated higher detection rates relative abundance second Preterm Birth (PTB) groups. S. yanoikuyae PTB group elevated frequencies Notably, negatively correlated activated partial thromboplastin time (APTT) (r = −0.329, P 0.016), while Staphylococcus showed positive correlations APTT 0.395, 0.003). Furthermore, birth weight −0.297, 0.034).ConclusionMost Certain may correlate such as gestational age PTB. However, these associations require further investigation. It is essential expand sample size undertake more comprehensive implications presence AF.
Language: Английский
Citations
1
Virus Research, Journal Year: 2024, Volume and Issue: 350, P. 199484 - 199484
Published: Oct. 25, 2024
Language: Английский
Citations
1
Biomedicines, Journal Year: 2024, Volume and Issue: 13(1), P. 59 - 59
Published: Dec. 30, 2024
The human endogenous retroviruses (HERVs) are ancient exogenous that were embedded in the germline over 30 million years ago and underwent an endogenization process. They make up roughly 8% of genome. HERVs exhibit many physiological non-physiological functions; for example, they play a role development diseases. have been shown to affect carcinogenesis by modifying expression host genes through their functions as enhancers promoters. Additionally, some molecules derived from may stimulate immune system. Recently research has focused on effect neurodegenerative diseases, including Alzheimer’s disease (AD), which is most common cause dementia. AD also linked significant deterioration quality life. article aims highlight potential diseases such senescence. Moreover, it estimated be targets diagnosis therapy AD.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 9972 - 9972
Published: June 9, 2023
Expression of human endogenous retrovirus type W (HERV-W) has been linked to cancer, making HERV-W antigens potential targets for therapeutic cancer vaccines. In a previous study, we effectively treated established tumours in mice by using adenoviral-vectored vaccines targeting the murine envelope and group-specific antigen (Gag) melanoma-associated (MelARV) combination with anti-PD-1. To break immunological tolerance MelARV, mutated immunosuppressive domain (ISD) MelARV envelope. However, reports on immunogenicity envelope, Syncytin-1, its ISD are conflicting. identify most effective vaccine candidate, evaluated encoding either wild-type or vitro vivo. Here, show that generated higher activation antigen-presenting cells specific T-cell responses than ISD-mutated counterpart. We also found was sufficient increase probability survival subjected envelope-expressing compared control vaccine. These findings provide foundation developing HERV-W-positive cancers humans.
Language: Английский
Citations
3
Pathologica, Journal Year: 2023, Volume and Issue: 115(5), P. 248 - 256
Published: Oct. 1, 2023
Even if the SARS-CoV-2 pandemic has been declared over, several risks and clinical problems remain to be faced, including long-COVID sequelae possible outbreaks of pathogenic variants. Intense research on COVID-19 provided in these few years a striking amount data covering different fields disciplines, which can help provide knowledge shield against new potential infective spreads, may also potentially applied other medicine, oncology neurology. Nevertheless, areas uncertainty still regarding mechanisms that subtend multifaceted manifestations disease. To better clarify pathogenesis disease, systematic multidisciplinary evaluation many involved is mandatory, clinical, physiological, radiological, immunological pathological studies. In syndrome studies have mainly performed autopsy cases, only are available biopsies. relevant information substantially contribute decipher complex scenario characterizing forms long-COVID-19. this review by investigations recapitulated discussed, light hypothesis physiological data. Keep reading
Language: Английский
Citations
2
The Journal of Physiology, Journal Year: 2024, Volume and Issue: 602(11), P. 2669 - 2672
Published: Feb. 2, 2024
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.
Language: Английский
Citations
0
Viruses, Journal Year: 2024, Volume and Issue: 16(7), P. 1111 - 1111
Published: July 11, 2024
In this study, we investigated the potential involvement of endogenous viral elements (EVEs) in development apical tissue necrosis, resulting terminal abortion upland cotton (Gossypium hirsutum L.) Georgia. The high-throughput sequence analysis symptomatic and asymptomatic plant samples revealed near-complete EVE-Georgia (EVE-GA) sequences closely related to caulimoviruses. EVE-GA’s putative open reading frames (ORFs) compared virus A pararetroviral (eCPRVE) their similarity ORFs 1–4. However, ORF 5 6 encoding coat protein reverse transcriptase, respectively, from EVE-GA have stop codons similar eCPRVE Mississippi. silico mining genome database using as a query uncovered insertions genomes G. species (~7 kb) but partial tomentosum (~5.3 mustelinum (~5.1 species. Furthermore, EVEs’ episomal forms messenger RNA (mRNA) transcripts were detected both plants collected fields. No significant yield difference was observed between two varieties evaluated experimental plot. Additionally, EVEs also seeds seedlings. This study emphasizes need for future research on EVE sequences, coding capacity, any role host immunity or pathogenicity.
Language: Английский
Citations
0