Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

Cell, Journal Year: 2012, Volume and Issue: 150(4), P. 780 - 791

Published: Aug. 1, 2012

Language: Английский

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Imaging Calcium in Neurons

Neuron, Journal Year: 2012, Volume and Issue: 73(5), P. 862 - 885

Published: March 1, 2012

Language: Английский

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Neural Control of Renal Function*

CRC Press eBooks, Journal Year: 2020, Volume and Issue: unknown, P. 493 - 528

Published: Feb. 3, 2020

The functional role of the renorenal reflexes in control contralateral renal function was first demonstrated studies examining effects total withdrawal unilateral afferent nerve activity by denervation. In rat, contrast to dog and cat which mechanoreceptor chemoreceptor stimulation elicits excitatory responses, nature neural responses sensory receptor suggests that are an inhibitory nature. Electrical results a frequency-dependent increase venous outflow norepinephrine renin secretion rate. Interest neurology kidney, is, significance innervation, has increased steadily following growth information concerning anatomy innervation. reflex nerves result frequencydependent overflow dopamine.

Language: Английский

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Central mechanisms of pathological pain

Nature Medicine, Journal Year: 2010, Volume and Issue: 16(11), P. 1258 - 1266

Published: Oct. 14, 2010

Language: Английский

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Activation of Platelet Function Through G Protein–Coupled Receptors

Circulation Research, Journal Year: 2006, Volume and Issue: 99(12), P. 1293 - 1304

Published: Dec. 7, 2006

Because of their ability to become rapidly activated at places vascular injury, platelets are important players in primary hemostasis as well arterial thrombosis. In addition, they also involved chronic pathological processes including the atherosclerotic remodeling system. Although adhesion vessel wall is largely independent G protein-mediated signaling, subsequent recruitment additional into a growing platelet thrombus requires mediators such ADP, thromboxane A(2), or thrombin, which act through protein-coupled receptors. Platelet activation via receptors involves 3 major signaling pathways that initiated by proteins G(q), G(13), and G(i). This review summarizes recent progress understanding mechanisms underlying extension pathways.

Language: Английский

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Illuminating G-Protein-Coupling Selectivity of GPCRs

Cell, Journal Year: 2019, Volume and Issue: 177(7), P. 1933 - 1947.e25

Published: June 1, 2019

Language: Английский

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Signaling pathways controlling skeletal muscle mass

Critical Reviews in Biochemistry and Molecular Biology, Journal Year: 2013, Volume and Issue: 49(1), P. 59 - 68

Published: Nov. 18, 2013

The molecular mechanisms underlying skeletal muscle maintenance involve interplay between multiple signaling pathways. Under normal physiological conditions, a network of interconnected signals serves to control and coordinate hypertrophic atrophic messages, culminating in delicate balance protein synthesis proteolysis. Loss mass, termed "atrophy", is diagnostic feature cachexia seen settings cancer, heart disease, chronic obstructive pulmonary kidney burns. Cachexia increases the likelihood death from these already serious diseases. Recent studies have further defined pathways leading gain loss as well events that induce differentiation post-injury regeneration, which are also essential for mass. In this review, we summarize discuss relevant recent literature demonstrating previously undiscovered mediators governing anabolism catabolism muscle.

Language: Английский

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GPR92 as a New G12/13- and Gq-coupled Lysophosphatidic Acid Receptor That Increases cAMP, LPA5

Journal of Biological Chemistry, Journal Year: 2006, Volume and Issue: 281(33), P. 23589 - 23597

Published: June 15, 2006

The signaling effects of lysophospholipids such as lysophosphatidic acid (LPA) are mediated by G protein-coupled receptors (GPCRs). There currently four LPA known LPA(1-4). Genetic deletion studies have identified essential biological functions for in mice. However, these also revealed phenotypes consistent with the existence yet unidentified receptors. Toward identifying new receptors, we screened collections GPCR cDNAs using reverse transfection and cell-based assays. Here report an interim result one screen to identify that produced LPA-dependent changes cell shape: orphan receptor GPR92 has properties a receptor. Sequence analyses human its mouse homolog approximately 35% amino identity LPA4/GPR23. same approaches were used and/or characterize LPA(1-4), particularly heterologous expression B103 cells or RH7777 cells, utilized compared Retroviral-mediated epitope-tagged was further combined protein minigenes pharmacological intervention, along calcium imaging whole-cell patch clamp electrophysiology. internalization following exposure but not related observed. Furthermore, induced concentration-dependent activation G(12/13) G(q) increased cAMP levels. Specific [3H]LPA binding detected membranes heterologously expressing control membranes. Northern blot transcriptase-PCR indicated broad low level many tissues including embryonic brain enrichment small intestine sensory dorsal root ganglia, well stem cells. These results support fifth receptor, LPA5, which likely distinct physiological view pattern.

Language: Английский

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Mitogenic signaling pathways induced by G protein‐coupled receptors

Journal of Cellular Physiology, Journal Year: 2007, Volume and Issue: 213(3), P. 589 - 602

Published: Sept. 4, 2007

Abstract G protein‐coupled receptor (GPCR) agonists, including neurotransmitters, hormones, chemokines, and bioactive lipids, act as potent cellular growth factors have been implicated in a variety of normal abnormal processes, development, inflammation, malignant transformation. Typically, the binding an agonistic ligand to its cognate GPCR triggers activation multiple signal transduction pathways that synergistic combinatorial fashion relay mitogenic nucleus promote cell proliferation. A rapid increase activity phospholipases C, D, A2 leading synthesis lipid‐derived second messengers, Ca 2+ fluxes subsequent protein phosphorylation cascades, PKC/PKD, Raf/MEK/ERK, Akt/mTOR/p70S6K is important early response agonists. The EGF (EGFR) tyrosine kinase has emerged transducer signaling by GPCRs, process termed transactivation. also induces striking morphological changes proteins, non‐receptor kinases Src, focal adhesion (FAK), adaptor proteins CAS paxillin. stimulated GPCRs are extensively interconnected antagonistic crosstalks play critical role transmission, integration, dissemination. purpose this article review recent advances defining transducing responses induced J. Cell. Physiol. 213:589–602. © 2007 Wiley‐Liss, Inc.

Language: Английский

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Organization and Ca²⁺Regulation of Adenylyl Cyclases in cAMP Microdomains

Physiological Reviews, Journal Year: 2007, Volume and Issue: 87(3), P. 965 - 1010

Published: July 1, 2007

The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine kinases, Ca 2+ . In some physiological situations, this regulation can be readily incorporated into hormonal cascade, controlling processes such as cardiac contractility or neurotransmitter release. However, the significance modes is obscure likely only to apparent in explicit cellular contexts (or stages cell cycle). many ACs ubiquitous second messenger provides an overarching mechanism for integrating activities these two major signaling systems. Elaborate devices have been evolved ensure that interaction occurs, guarantee fidelity interaction, insulate microenvironment which it occurs. Subcellular targeting, well variety scaffolding devices, used promote with specific proteins regulatory factors generate privileged domains cAMP signaling. A direct consequence organization will exhibit distinct kinetics discrete domains. means now available study dissect their components real time live cells. These topics explored within present review.

Language: Английский

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