Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

Cell, Journal Year: 2015, Volume and Issue: 163(4), P. 811 - 828

Published: Nov. 1, 2015

Language: Английский

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The Hippo pathway and human cancer

Nature reviews. Cancer, Journal Year: 2013, Volume and Issue: 13(4), P. 246 - 257

Published: March 7, 2013

Language: Английский

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YAP/TAZ at the Roots of Cancer

Cancer Cell, Journal Year: 2016, Volume and Issue: 29(6), P. 783 - 803

Published: June 1, 2016

Language: Английский

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The Biology of YAP/TAZ: Hippo Signaling and Beyond

Physiological Reviews, Journal Year: 2014, Volume and Issue: 94(4), P. 1287 - 1312

Published: Oct. 1, 2014

The transcriptional regulators YAP and TAZ are the focus of intense interest given their remarkable biological properties in development, tissue homeostasis cancer. activity is key for growth whole organs, amplification tissue-specific progenitor cells during renewal regeneration, cell proliferation. In tumors, YAP/TAZ can reprogram cancer into stem incite tumor initiation, progression metastasis. As such, appealing therapeutic targets regenerative medicine. Just like function offers a molecular entry point mysteries biology, regulation by upstream cues equally captivating. well known being effectors Hippo signaling cascade, mouse mutants pathway components display phenotypes organ overgrowth, enhanced content reduced cellular differentiation. primary sensors cell's physical nature, as defined structure, shape polarity. activation also reflects “social” behavior, including adhesion mechanical signals that receives from architecture surrounding extracellular matrix (ECM). At same time, entertain relationships with morphogenetic signals, such Wnt factors, regulated Rho, GPCRs mevalonate metabolism. thus appear at centerpiece nexus which take control behavior according to own shape, spatial location factor context.

Language: Английский

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A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

Cell, Journal Year: 2013, Volume and Issue: 154(5), P. 1047 - 1059

Published: Aug. 1, 2013

Language: Английский

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Mechanisms of Hippo pathway regulation

Genes & Development, Journal Year: 2016, Volume and Issue: 30(1), P. 1 - 17

Published: Jan. 1, 2016

The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied both mammals the last several years. core of consists kinase cascade, transcription coactivators, DNA-binding partners. Recent studies have expanded as complex signaling network with >30 components. This is regulated by intrinsic cell machineries, such cell–cell contact, polarity, actin cytoskeleton, well wide range signals, including cellular energy status, mechanical cues, hormonal signals that act through G-protein-coupled receptors. major functions defined to restrict adults modulate proliferation, differentiation, migration developing organs. Furthermore, dysregulation leads aberrant neoplasia. In this review, we focus on recent developments our understanding molecular actions cascade discuss key open questions regulation function pathway.

Language: Английский

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Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Nature Cell Biology, Journal Year: 2013, Volume and Issue: 15(6), P. 637 - 646

Published: May 24, 2013

Language: Английский

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The Hippo pathway: regulators and regulations

Genes & Development, Journal Year: 2013, Volume and Issue: 27(4), P. 355 - 371

Published: Feb. 15, 2013

Control of cell number is crucial in animal development and tissue homeostasis, its dysregulation may result tumor formation or organ degeneration. The Hippo pathway both Drosophila mammals regulates by modulating proliferation, death, differentiation. Recently, numerous upstream components involved the have been identified, such as polarity, mechanotransduction, G-protein-coupled receptor (GPCR) signaling. Actin cytoskeleton cellular tension appears to be master mediator that integrates transmits signals core signaling cascade. Here, we review regulatory mechanisms discuss potential implications different physiological pathological conditions.

Language: Английский

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Mechanobiology of YAP and TAZ in physiology and disease

Nature Reviews Molecular Cell Biology, Journal Year: 2017, Volume and Issue: 18(12), P. 758 - 770

Published: Sept. 27, 2017

Language: Английский

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The Hippo Pathway: Biology and Pathophysiology

Annual Review of Biochemistry, Journal Year: 2018, Volume and Issue: 88(1), P. 577 - 604

Published: Dec. 19, 2018

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size control, regeneration. core the mammals consists kinase cascade, MST1/2 LATS1/2, well downstream effectors, transcriptional coactivators YAP TAZ. These components control programs involved proliferation, survival, mobility, stemness, differentiation. tightly regulated by both intrinsic extrinsic signals, such mechanical force, cell-cell contact, polarity, energy status, stress, many diffusible hormonal factors, majority which act through G protein-coupled receptors. Here, we review current understanding molecular mechanisms signals regulate with emphasis on mechanotransduction effects this basic biology human diseases.

Language: Английский

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