Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 189251 - 189251
Published: Dec. 1, 2024
Language: Английский
Immunity, Journal Year: 2024, Volume and Issue: 57(8), P. 1939 - 1954.e7
Published: July 15, 2024
Language: Английский
Citations
19
iMeta, Journal Year: 2024, Volume and Issue: 3(5)
Published: Sept. 14, 2024
Abstract Gut microbiota is an intricate microbial community containing bacteria, fungi, viruses, archaea, and protozoa, each of them contributes to diverse aspects host health. Nevertheless, the influence interaction among gut on health remains uncovered. Here, we showed that between intestinal fungi bacteria shaped lung inflammation during infection. Specifically, antifungal drug‐induced dysbiosis mycobiota enhanced Dysbiosis led Escherichia coli ( E. ) overgrowth translocation infection, which induced accumulation CD45 + F4/80 Ly6G − Ly6C CD11b CD11c macrophages. Clearance macrophages or deletion TLR4 (Toll‐like receptor 4, recognition LPS) rather than Dectin‐1 (recognition beta‐1,3/1,6 glucans fungi) blocked aggravation These findings suggest commensal affects through gut–lung axis, offering a potential therapeutic target for ameliorating
Language: Английский
Citations
9
Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)
Published: May 31, 2024
In the past decade, intestinal organoid technology has paved way for reproducing tissue or organ morphogenesis during physiological processes in vitro and studying pathogenesis of various diseases. Intestinal organoids are favored drug screening due to their ability high-throughput cultivation closer resemblance patient genetic characteristics. Furthermore, as disease models, find wide applications diagnostic markers, identifying therapeutic targets, exploring epigenetic mechanisms Additionally, a transplantable cellular system, have played significant role reconstruction damaged epithelium conditions such ulcerative colitis short bowel syndrome, well material exchange metabolic function restoration. The rise interdisciplinary approaches, including organoid-on-chip technology, genome editing techniques, microfluidics, greatly accelerated development organoids. this review, VOSviewer software is used visualize hot co-cited journal keywords trends firstly. Subsequently, we summarized current modeling, screening, regenerative medicine. This will deepen our understanding further explore intestine
Language: Английский
Citations
8
Journal of Cancer, Journal Year: 2025, Volume and Issue: 16(4), P. 1040 - 1050
Published: Jan. 1, 2025
The gut microbiota plays a significant role in the initiation and progression of tumors, but its rectal neuroendocrine tumors (rNETs) remains unclear. Fecal samples were collected from 19 healthy individuals 21 rNET patients,with cohort further divided into metastatic (rNETs-M) non-metastatic (rNETs-nM) groups. Using metagenomic high-throughput sequencing, we analyzed diversity, species composition, functional characteristics microbiota. We applied random forest model to identify potential microbial biomarkers for predicting specifically distinguishing rNETs-M cases. Alpha diversity analysis revealed that was lower rNETs group than control group. In contrast, exhibited higher rNETs-nM Beta demonstrated differences community structure between groups rNET-M Notably, group, abundance pathogens such as Escherichia coli Shigella elevated.Furthermore, an increased Alistipes. KEGG enrichment indicated these distinct play environmental information processing, genetic metabolic pathways. Random ROC curve results identified Lachnospira pectinoschiza (AUC=0.885), Parasutterella muris (AUC=0.862), Sodaliphilus pleomorphus(AUC=0.956), Methylobacterium iners (AUC=0.971) with discriminatory value.
Language: Английский
Citations
0
Cell, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Immunological Reviews, Journal Year: 2025, Volume and Issue: 330(1)
Published: March 1, 2025
ABSTRACT Asthma is one of the most prevalent and extensively studied chronic respiratory conditions, yet heterogeneity asthma remains biologically puzzling. Established factors like exogenous exposures treatment adherence contribute to variability in risk clinical outcomes. It also clear that endogenous genetics immune system response patterns play key roles asthma. Despite significant existing knowledge above, divergent trajectories outcomes are still observed, even among individuals with similar profiles, biomarkers, optimal medical management. This suggests uncaptured biological interactions asthma's heterogeneity, for which role host microbiota has lately attracted much research attention. review will highlight recent evidence this area, focusing on bedside‐to‐bench investigations have leveraged omic technologies uncover microbiome links immunobiology. Studies centered use multi‐omics noted particular. These represent a new generation reverse‐translational revealing potential functional crosstalk microbiomes may drive phenotypic diseases Multi‐omic data offer wide lens into ecosystem within host. informs hypotheses experimental work elucidate mechanistic pathways unresolved endotypes. Further incorporation patient‐centered can yield insights hopefully lead more precise, microbiome‐informed strategies reduce burden.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: March 18, 2025
Respiratory viral infections are a major global public health concern, and current antiviral therapies still have limitations. In recent years, research has revealed significant similarities between the immune systems of gut lungs, which interact through complex physiological network known as "gut-lung axis." As one largest organs, gut, along with forms an inter-organ network, strong parallels in innate mechanisms, such activation pattern recognition receptors (PRRs). Furthermore, microbiota influences responses lungs mechanisms systemic transport microbiota-derived metabolites, cell migration, cytokine regulation. Studies shown that dysbiosis can exacerbate severity respiratory may impact efficacy therapies. This review discusses synergistic role gut-lung axis immunity against viruses explores potential strategies for modulating to mitigate infections. Future should focus on drive development novel clinical treatment strategies.
Language: Английский
Citations
0
European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)
Published: April 4, 2025
Abstract The respiratory tract microbiome, a complex ecosystem of microorganisms colonizing the mucous layers and epithelial surfaces along with their associated microenvironment, plays vital role in maintaining function promoting maturation immune system. Current research suggests that environmental changes can disrupt microbiota, potentially leading to disease. This review summarizes existing on impact factors microbiome diseases, aiming offer new insights into prevention treatment
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: April 4, 2025
Background Neonatal Respiratory Distress Syndrome (NRDS) is a common and severe respiratory disorder in neonates, particularly among preterm infants (PTIs), often associated with hypoxemia multiple organ dysfunction. This study aims to investigate the gut microbiota characteristics NRDS potential regulatory role of probiotics restoring dysbiosis. Methods enrolled 55 PTIs diagnosed 26 without NRDS. The group was classified into two groups based on treatment: an antibiotic-only (TA group, N = 30) antibiotic plus (TB 25). Fecal samples were collected within 48 h birth again after recovery, for 16S rRNA sequencing. Results revealed that diversity significantly greater than non-NRDS composition closely clinical indicators, including Apgar score, pH, PaO 2 , PaCO . Notably, abundance bacteria such as Muribaculaceae Incertae Sedis Rhodococcus Corynebacterium higher which may contribute disease progression. ROC analysis suggested could serve biomarkers diagnosing Probiotic intervention notably restored structure by enhancing beneficial genera Streptococcus Bifidobacterium Clostridium reduced disparity between normal one-month-old children, thereby slowing Conclusion demonstrated displayed increase alterations specific bacterial populations, both correlated data. treatment aids disrupted infants, promoting providing new strategies managing
Language: Английский
Citations
0
Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964
Published: April 8, 2025
The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.
Language: Английский
Citations
0