Relationship Between Metabolic Age Determined by Bioimpedance and Insulin Resistance Risk Scales in Spanish Workers DOI Open Access
Ignacio Ramírez-Gallegos, Pedro Juan Tárraga López, Hernán Paublini

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 945 - 945

Published: March 8, 2025

Introduction: Metabolic age (MA) is the difference between an individual’s actual and of their body based on physiological biological factors. It indicator that reflects a person’s physical state, regardless chronological age. Insulin resistance (IR) health disorder in which tissues exhibit reduced response to circulating glucose uptake stimulated by insulin. Objective: The aim this study evaluate association MA, determined through bioelectrical impedance analysis, risk IR, assessed using validated scales, cohort Spanish workers. Methodology: A descriptive cross-sectional was conducted 8590 workers assess MA set sociodemographic variables, habits, IR scales such as Triglyceride–Glucose Index (TyG Index), Score for Resistance (METS-IR), Single Point Sensitivity Estimator (SPISE). Results: All analyzed variables were associated with values, strongest associations observed scale values (OR 4.88 [95% CI 4.12–5.65] METS-IR, 4.42 3.70–5.15] SPISE, 3.42 2.97–3.87] TyG Index) activity. Conclusions: influenced age, sex, social class; habits smoking, activity, adherence Mediterranean diet; values.

Language: Английский

Sedentary behavior and lifespan brain health DOI
Liye Zou, Fabian Herold, Boris Cheval

et al.

Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: 28(4), P. 369 - 382

Published: March 1, 2024

Language: Английский

Citations

40
The Vicious Cycle of Type 2 Diabetes Mellitus and Skeletal Muscle Atrophy: Clinical, Biochemical, and Nutritional Bases DOI Open Access
José M. López-Pedrosa,

María Camprubí-Robles,

Germán Guzmán-Rolo

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(1), P. 172 - 172

Published: Jan. 4, 2024

Today, type 2 diabetes mellitus (T2DM) and skeletal muscle atrophy (SMA) have become increasingly common occurrences. Whether the onset of T2DM increases risk SMA or vice versa has long been under investigation. Both conditions are associated with negative changes in health, which can, turn, lead to impaired physical function, a lowered quality life, an increased mortality. Poor nutrition can exacerbate both SMA. linked by vicious cycle events that reinforce worsen each other. Muscle insulin resistance appears be pathophysiological link between To explore this association, our review (i) compiles evidence on clinical association SMA, (ii) reviews mechanisms underlying biochemical muscles people at (iii) examines how nutritional therapy activity as muscle-targeted treatments benefit population. Based evidence, we conclude effective treatment patients T2DM-SMA depends restoration maintenance mass. We thus propose regular intake key functional nutrients, along guidance for activity, help maintain euglycemia improve status all

Language: Английский

Citations

20
Effects of accelerometer-based sedentary time and physical activity on DEXA-measured fat mass in 6059 children DOI Creative Commons
Andrew O. Agbaje, Wei Perng, Tomi‐Pekka Tuomainen

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Dec. 12, 2023

Globally, childhood obesity is on the rise and effect of objectively measured movement behaviour body composition remains unclear. Longitudinal causal mediation relationships accelerometer-based sedentary time (ST), light physical activity (LPA), moderate-to-vigorous (MVPA) with dual-energy X-ray absorptiometry-measured fat mass were examined in 6059 children aged 11 years followed-up until age 24 from Avon Study Parents Children (ALSPAC), UK birth cohort. Over 13-year follow-up, each minute/day ST was associated 1.3 g increase mass. However, LPA 3.6 decrease MVPA Persistently accruing ≥60 min/day 2.8 per MVPA, partly mediated by insulin low-density lipoprotein cholesterol. elicited similar potentially stronger mass-lowering than thus may be targeted prevention adolescents, who are unable or unwilling to exercise.

Language: Английский

Citations

27
The Effect of Sedentary Behaviour on Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis DOI Creative Commons
Stéphanie A. Prince, Paddy C. Dempsey, Jennifer L. Reed

et al.

Sports Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 16, 2024

Abstract Background Cardiorespiratory fitness (CRF) is an important indicator of current and future health. While the impact habitual physical activity on CRF well established, role sedentary behaviour (SB) remains less understood. Objective We aimed to determine effect SB CRF. Methods Searches were conducted in MEDLINE, Embase, PsycINFO, CINAHL SPORTDiscus from inception August 2022. Randomised controlled trials, quasi-experimental studies cohort that assessed relationship between eligible. Narrative syntheses meta-analyses summarised evidence, Grading Recommendations, Assessment, Development Evaluation (GRADE) certainty was based evidence randomised trials. Results This review included 18 focused youth (four three studies, 11 studies) 24 adult populations (15 five four studies). In adults, trials suggests mixed effects CRF, but with potential for interventions improve Quasi-experimental also support similar conclusions. Certainty very low both age groups. A meta-analysis found targeting reducing SB, or increasing had a significant post-peak oxygen consumption (mean difference = 3.16 mL . kg –1. min –1 , 95% confidence interval: 1.76, 4.57). Conclusions Evidence indicates associations influence as supported by meta-analytical findings. Further well-designed are warranted confirm explore independent higher intensity activity, investigate existence such relationships paediatric populations. Clinical Trial Registration PROSPERO CRD42022356218.

Language: Английский

Citations

15
Mitochondrial membrane lipids in the regulation of bioenergetic flux DOI Creative Commons

Stephen Thomas Decker,

Katsuhiko Funai

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(9), P. 1963 - 1978

Published: Aug. 23, 2024

SummaryOxidative phosphorylation (OXPHOS) occurs through and across the inner mitochondrial membrane (IMM). Mitochondrial membranes contain a distinct lipid composition, aided by biosynthetic machinery localized in IMM class-specific transporters that limit traffic out of mitochondria. This unique composition appears to be essential for functions mitochondria, particularly OXPHOS, its effects on direct lipid-to-protein interactions, properties, cristae ultrastructure. review highlights biological significance lipids, with particular spotlight role lipids bioenergetics. We describe pathways biosynthesis provide evidence their roles physiology, implications human disease, mechanisms which they regulate

Language: Английский

Citations

15
Effects of reducing sedentary behaviour by increasing physical activity, on cognitive function, brain function and structure across the lifespan: a systematic review and meta-analysis DOI
Natan Feter, Tomasz S. Ligeza,

Neha Bashir

et al.

British Journal of Sports Medicine, Journal Year: 2024, Volume and Issue: 58(21), P. 1295 - 1306

Published: Aug. 28, 2024

To examine the acute and chronic effects of reducing prolonged sedentary time (ST) with physical activity (PA) on cognitive brain health. Systematic review meta-analysis. PubMed, Scopus, CINAHL, PsycINFO, SPORTDiscus, Web Science, ProQuest Dissertation Theses. Randomised controlled trials (RCTs) published from inception to 17 June 2024, healthy participants without impairment or neurological conditions that affect functioning, aged ≥4 years, testing ST and/or by reallocating PA function, structure. We included 25 RCTs (n=1289) investigating (21 studies) (4 function (acute: n=20, chronic: n=4) n=7, n=1); there were no studies Acutely interrupting continuous either multiple a single bout improved measured 3 hours three consecutive days based 91 effect sizes (g=0.17, 95% CI: 0.05 0.29, p=0.005, I 2=45.5%). When comparing versus bouts, only bouts yielded positive 72 (g=0.20, 0.06 0.35, p=0.006; 2=48.8%). Chronic reported null findings (n=4), some evidence neural efficiency hippocampus (n=1). Interrupting acutely improves function. The remains inconclusive. PROSPERO CRD42020200998.

Language: Английский

Citations

9
Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms DOI Open Access

Jon L. Pertab,

Tricia L. Merkley,

Holly R. Winiarski

et al.

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(1), P. 33 - 33

Published: Jan. 17, 2025

A significant proportion of patients who sustain a concussion/mild traumatic brain injury endorse persisting, lingering symptoms. The symptoms associated with concussion are nonspecific, and many other medical conditions present similar Medical that overlap symptomatically include anxiety, depression, insomnia, chronic pain, fatigue, fibromyalgia, cervical strain injuries. One the factors may account for these similarities is all disturbances in optimal functioning autonomic nervous system its intricate interactions endocrine immune system—the three primary regulatory systems body. When clinicians working presenting persisting after concussion, evidence-based treatment options drawn from literature limited. We framework assessment following based on available evidence (treatment trials), neuroanatomical principles (research into physiology concussion), clinical judgment. review research supporting premise behavioral interventions designed to stabilize optimize body have potential reduce improve patients. Foundational rehabilitation strategies areas sleep stabilization, fatigue management, physical exercise, nutrition, relaxation protocols, activation outlined along practical implementing intervention modules

Language: Английский

Citations

1
Enhanced muscle activity during interrupted sitting improves glycemic control in overweight and obese men DOI
Ying Gao, Q.-H. Li, Taija Finni

et al.

Scandinavian Journal of Medicine and Science in Sports, Journal Year: 2024, Volume and Issue: 34(4)

Published: April 1, 2024

Abstract The efficacy of interrupting prolonged sitting may be influenced by muscle activity patterns. This study examined the effects time with different patterns on continuously monitored postprandial glycemic response. Eighteen overweight and obese men (21.0 ± 1.2 years; 28.8 2.2 kg/m 2 ) participated in this randomized four‐arm crossover study, including uninterrupted for 8.5 h (SIT) interruptions matched energy expenditure duration but varying activity: 30‐min walking at 4 km/h (ONE), 3‐min (WALK) or squatting (SQUAT) every 45 min 10 times. Net incremental area under curve ( net iAUC) glucose was compared between conditions. Quadriceps, hamstring, gluteal muscles electromyogram (EMG) averaged EMG amplitude (aEMG) were used to predict iAUC. Compared SIT (10.2 mmol/L/h [95%CI 6.3 11.7]), iAUC lower during interrupted any countermeasure (ONE 9.2 [8.0 10.4], WALK 7.9 [6.4 9.3], SQUAT all p < 0.05). Furthermore, resulted a ONE (both Only increased aEMG quadriceps (−0.383 [−0.581 −0.184], 0.001) (−0.322 [−0.593 −0.051], = 0.022) associated reduction Collectively, short, frequent breaks effectively enhance control single bout within sitting. These superior benefits seem intensity targeted groups transitions from activity.

Language: Английский

Citations

6
Cancer Therapy and Exercise Intolerance: The Heart Is but a Part DOI Creative Commons
Hayley T. Dillon, Stephen J. Foulkes, Alan H. Baik

et al.

JACC CardioOncology, Journal Year: 2024, Volume and Issue: 6(4), P. 496 - 513

Published: June 5, 2024

The landscape of cancer therapeutics is continually evolving, with successes in improved survivorship and reduced disease progression for many patients cancer. Improved outcomes expose competing comorbidities, some which may be exacerbated by therapies. leading cause disability death early-stage cancers cardiovascular (CVD), often attributed to direct or indirect cardiac injury from therapy. In this review, the authors propose that toxicities related conventional novel should considered beyond heart. provide a framework using oxygen pathway understand impact treatment on peak uptake, marker integrative cardiopulmonary function CVD risk. Peripheral transport are discussed. Consideration broad effects therapies will improve prediction identification survivors at risk CVD, functional disability, premature mortality those who would benefit therapeutic intervention, ultimately improving patient outcomes.

Language: Английский

Citations

6
Associations of Sedentary Time and Physical Activity From Childhood With Lipids: A 13-Year Mediation and Temporal Study DOI Creative Commons
Andrew O. Agbaje

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 109(7), P. e1494 - e1505

Published: Nov. 23, 2023

Among children, evidence on long-term longitudinal associations of accelerometer-measured sedentary time, light physical activity (LPA), and moderate to vigorous PA (MVPA) with lipid indices are few. The mediating role body composition other metabolic in these remains unclear whether poor movement behavior precedes altered levels is unknown.

Language: Английский

Citations

14