Type 2 diabetes-related sarcopenia: role of nitric oxide DOI Creative Commons
Zahra Bahadoran, Parvin Mirmiran, Asghar Ghasemi

et al.

Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 21(1)

Published: Dec. 18, 2024

Sarcopenia, characterized by progressive and generalized loss of skeletal muscle (SkM) mass, strength, physical performance, is a prevalent complication in type 2 diabetes (T2D). Nitric oxide (NO), multifunctional gasotransmitter involved whole-body glucose insulin homeostasis, plays key roles normal SkM physiology function. Here, we highlight the role NO mass maintenance its potential contribution to development T2D-related sarcopenia. Physiologic level, primarily produced sarcolemmal neuronal nitric synthase (nNOSμ isoform), protein synthesis fibers mass. The observed effect nNOSμ on muscle-type specific sex-dependent. Impaired homeostasis [due diminished nNOSμ-NO availability excessive production through inducible NOS (iNOS) response atrophic stimuli, e.g., inflammatory cytokines] occurred during progression T2D, may cause Theoretically, restoration nNOS overexpression, supplying substrates (e.g., L-arginine L-citrulline), phosphodiesterase (PDE) inhibition, supplementation with donors inorganic nitrate) be therapeutic approaches preserve prevents sarcopenia T2D.

Language: Английский

Skeletal muscle disorders as risk factors for type 2 diabetes. DOI Creative Commons
Eshwar R. Tammineni, Carlo Manno, Goldie Oza

et al.

Molecular and Cellular Endocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 112466 - 112466

Published: Jan. 1, 2025

Language: Английский

Citations

2
Dietary intake by patients taking GLP-1 and dual GIP/GLP-1 receptor agonists: A narrative review and discussion of research needs DOI Creative Commons
Sandra M. Christensen, Katie N. Robinson, Sara Thomas

et al.

Obesity Pillars, Journal Year: 2024, Volume and Issue: 11, P. 100121 - 100121

Published: July 25, 2024

Obesity and type 2 diabetes mellitus (T2DM) are increasingly common in the United States worldwide. Because both conditions associated with serious health consequences, weight reduction is recommended by professional medical nutrition societies to improve outcomes. Due striking efficacy of glucagon-like peptide receptor agonists (GLP-1RAs) dual mechanism glucose-dependent insulinotropic polypeptide/glucagon-like (GIP/GLP-1RAs) for glycemic control, there increased utilization patients obesity and/or T2DM. Yet, impact these medications on dietary intake less understood. This narrative literature review summarizes clinical studies quantifying characterizing people T2DM using GLP-1 or GIP/GLP-1 RAs. Though data from reveal that total caloric was reduced 16–39 %, few evaluated actual composition diet. Further research needed understand unique nutritional needs adults GIP/GLP-1RAs support development guidelines individuals.

Language: Английский

Citations

11
Chronic Obstructive Pulmonary Disease and Type 2 Diabetes Mellitus: Complex Interactions and Clinical Implications DOI Open Access
Lucreția Anghel, Anamaria Ciubară,

Diana Pătraș

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1809 - 1809

Published: March 7, 2025

Chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) are highly prevalent chronic conditions, frequently coexisting due to their shared pathophysiological mechanisms risk factors. Epidemiological studies estimate that up 30% of COPD patients have comorbid T2DM, contributing worsened progression, more hospitalizations, higher mortality rates. Systemic inflammation in contributes insulin resistance by increasing pro-inflammatory cytokines (TNF-α, IL-6, CRP), which impair glucose metabolism beta-cell function. Conversely, hyperglycemia T2DM exacerbates oxidative stress, leading endothelial dysfunction, reduced lung function, impaired repair mechanisms. A comprehensive narrative review was conducted evaluate the interplay between examining mechanisms, clinical consequences, management strategies. The co-occurrence accelerates development, elevates hospitalization rates, deteriorates overall prognosis. Pharmacological interactions complicate illness treatment, requiring a multidisciplinary therapy strategy. Recent data underscore need integrate palliative care, facilitate decision-making, provide psychological support enhance patient outcomes. Efficient COPD-T2DM comorbidity necessitates customized, interdisciplinary strategy targets both respiratory metabolic health. Preliminary prognostic dialogues, holistic lifestyle modifications can improve quality life results.

Language: Английский

Citations

1
Unraveling the role of muscle mass and strength in predicting type 2 diabetes risk: a systematic review DOI
Hans Putranata, Antoninus Hengky,

Budhi Hartoko

et al.

Acta Diabetologica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Language: Английский

Citations

0
Medical Nutrition Therapy and Physical Exercise for Acute and Chronic Hyperglycemic Patients with Sarcopenia DOI Open Access
Ángel Luis Abad-González, Silvia Veses Martín, María Argente

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 499 - 499

Published: Jan. 29, 2025

A wide range of factors contribute to the overlap hyperglycemia—acute or chronic—and sarcopenia, as well their associated adverse consequences, which can lead impaired physical function, reduced quality life, and increased mortality risk. These include malnutrition (both overnutrition undernutrition) low levels activity. Hyperglycemia sarcopenia are interconnected through a vicious cycle events that mutually reinforce worsen each other. To explore this association, our review compiles evidence on: (i) impact hyperglycemia on motor muscle with focus mechanisms underlying biochemical changes in muscles individuals at risk diabetes sarcopenia; (ii) importance clinical assessment control under hyperglycemic conditions; (iii) potential benefits medical nutrition therapy activity muscle-targeted treatments for population. Based reviewed evidence, we conclude regular intake key functional nutrients, together structured supervised resistance and/or aerobic activity, help maintain euglycemia improve status all patients sarcopenia.

Language: Английский

Citations

0
Are strategies to increase muscle mass and strength as effective in people with type 2 diabetes? DOI Creative Commons
Amina Al-Awadi, Stuart R. Gray, Ebaa Al‐Ozairi

et al.

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

People with type 2 diabetes (T2D) have a 2–3-time higher risk of developing sarcopenia, musculoskeletal disease marked by progressive loss skeletal muscle mass and strength, compared to people without T2D. This narrative review examines the effectiveness lifestyle interventions in enhancing strength T2D, emphasizing their growing importance advancements obesity treatments. PubMed Google Scholar were utilized identify most relevant published studies based on authors' knowledge. The maintenance T2D is becoming more prominent due advent weight therapies such as low-energy diets, bariatric surgery pharmacotherapies. Although be commended, large proportion (20–50%) comes from lean mass, indicative mass. There are currently no pharmacotherapies increase, or mitigate of, strategies this arena. Resistance exercise effective method increase but there some evidence an anabolic resistance. Aerobic increased dietary protein intake may result small increases resistance these stimuli. Exercise supplementation can aid retention individuals further research needed explore benefits patients undergoing concomitant pharmaceutical surgical

Language: Английский

Citations

0
Skeletal muscle atrophy and dysfunction in obesity and type-2 diabetes mellitus: Myocellular mechanisms involved DOI Creative Commons
Inmaculada Castillo, Josep M. Argilés, Ricardo Rueda

et al.

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Abstract Obesity and type-2 diabetes mellitus (T2DM) are interrelated metabolic disorders primarily driven by overnutrition physical inactivity, which oftentimes entails a transition from obesity to T2DM. Compromised musculoskeletal health consistently emerges as common hallmark in the progression of these disorders. Skeletal muscle atrophy dysfunction can further impair whole-body metabolism reduce exercise capacity, thus instigating vicious cycle that deteriorates underlying conditions. However, myocellular repercussions disturbances remain be completely clarified. Insulin signaling not only facilitates skeletal glucose uptake but also plays central role anabolism mainly due suppression catabolic pathways facilitating an anabolic response nutrient feeding. Chronic may trigger different mechanisms proposed contribute insulin resistance aggravate dysfunction. These include inactivation components through sustained activation stress-related pathways, mitochondrial dysfunction, shift glycolytic fibers, hyperglycemia. In present review, we aim delve on mechanisms, providing overview processes involved under chronic overnutrition, their contribution

Language: Английский

Citations

0
Age- and sex-specific reference values for CT-based low skeletal muscle quantity and quality in healthy living kidney donors DOI Creative Commons
David Martin,

Paola Dolce,

Martin Hübner

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Computed tomography (CT) imaging is a useful tool for assessing skeletal muscle mass and quality. The present study aimed to determine age- sex-specific reference values CT-based markers in healthy population, correlate them with serum creatinine 24-h urinary excretion (24h-UCE). Skeletal index (SMI) - marker of mass/quantity radiation attenuation (SMRA) intermuscular adipose tissue (IMATI) quality/myosteatosis were determined using deep-learning-based method from axial CT images at the level 3rd lumbar vertebra living kidney donors assessed between 01/2005 05/2023. Age- by 5th percentile, correlation was tested Pearson coefficient. scans 394 individuals included. mean age 53 years (SD 12), BMI 25.2 kg/m2 3.9), 130 patients (33%) male. low males 43.7 cm2/m2 (20-39 years), 44.9 (40-59 39.7 (≥60 years). In females, corresponding 33.8 34.8 31.2 SMI showed moderate (r = 0.452, p < 0.001) but weak 24h-UCE 0.188, 0.003). Correlations all SMRA (creatinine: r 0.220, 0.001; 24h-UCE: 0.177, 0.006) IMATI -0.101, 0.054; 24h-UCE, -0.108, 0.093). reported here could be used clinical practice future studies identify risk decline.

Language: Английский

Citations

0
Association of the cardiometabolic index with sarcopenia among U.S. adults: NHANES 2011–2018 findings DOI Creative Commons
Qing Zhao,

Yue Xu,

Xiaotian Chen

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0323905 - e0323905

Published: May 15, 2025

Background The cardiometabolic index (CMI), initially devised as a diagnostic tool for diabetes mellitus, has evolved into composite biomarker evaluating metabolic syndrome and cardiovascular disease risk. In order to shed light on any possible interactions between sarcopenia CMI, this study will look at the relationship two. Methods results Data from 2011–2018 National Health Nutrition Examination Survey (NHANES) were analyzed investigate link CMI. Among 3,185 eligible participants, weighted prevalence of was 7.84%. A significant positive association emerged CMI risk, with each unit increase in linked 12% greater risk fully adjusted model (OR: 1.12; 95% CI: 1.01–1.26). Moreover, dose-response relationships evident across tertiles ( P trend < 0.05). Subgroup analyses interaction tests indicated that correlation differs significantly subgroups defined by education level, sedentary time CVD status (all Conclusions Our findings demonstrate robust elevated levels increased suggesting CMI’s potential utility clinical surveillance. To confirm these causality, more research is required.

Language: Английский

Citations

0
Association between remote resistance exercises programs delivered by a smartphone application and skeletal muscle mass among elderly patients with type 2 diabetes– a retrospective real-world study DOI Creative Commons
Yang Jing,

Hongyu Tan,

Haoyan Yu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: June 11, 2024

We aimed to explore the relationship between remote resistance exercise programs delivered via a smartphone application and skeletal muscle mass among elderly patients with type 2 diabetes, utilizing real-world data.

Language: Английский

Citations

2