Spiritual Health and Stress in Pregnant Women During the Covid-19 Pandemic DOI Creative Commons
Reza Jafari Nodoushan,

Hadi Alimoradi,

Mahsa Nazari

et al.

SN Comprehensive Clinical Medicine, Journal Year: 2020, Volume and Issue: 2(12), P. 2528 - 2534

Published: Oct. 16, 2020

Stress is one of the effective factors in occurrence negative effects during pregnancy that can cause adverse outcomes such as preterm delivery and reduced intrauterine growth fetus pregnant women. Therefore, serious concerns COVID-19 pandemic physical health mental This study aimed to evaluate status with spiritual women pandemic. The a descriptive 2019-2020 samples were randomly selected from all who referred hospitals private maternity centers before performed fetal tests. It was on 560 female samples. assessed using DASS Spiritual Health Questionnaire. Data analysis SPSS statistical software (version 24). results this showed birth, height, weight, head circumference babies lungs respiratory children stress levels corona are significant compared previous (

Language: Английский

The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis DOI Creative Commons
Shu Qin Wei, Marianne Bilodeau‐Bertrand, Shiliang Liu

et al.

Canadian Medical Association Journal, Journal Year: 2021, Volume and Issue: 193(16), P. E540 - E548

Published: March 19, 2021

The impact of coronavirus disease 2019 (COVID-19) on maternal and newborn health is unclear. We aimed to evaluate the association between severe acute respiratory syndrome 2 (SARS-CoV-2) infection during pregnancy adverse outcomes.We conducted a systematic review meta-analysis observational studies with comparison data SARS-CoV-2 severity COVID-19 pregnancy. searched for eligible in MEDLINE, Embase, ClinicalTrials.gov, medRxiv Cochrane databases up Jan. 29, 2021, using Medical Subject Headings terms keywords "severe OR COVID-19" AND "pregnancy." evaluated methodologic quality all included Newcastle-Ottawa Scale. Our primary outcomes were preeclampsia preterm birth. Secondary stillbirth, gestational diabetes other outcomes. calculated summary odds ratios (ORs) or weighted mean differences 95% confidence intervals (CI) random-effects meta-analysis.We 42 involving 438 548 people who pregnant. Compared no pregnancy, was associated (OR 1.33, CI 1.03 1.73), birth 1.82, 1.38 2.39) stillbirth 2.11, 1.14 3.90). mild COVID-19, strongly 4.16, 1.55 11.15), 4.29, 2.41 7.63), 1.99, 1.09 3.64) low weight 1.89, 3.12).COVID-19 may be increased risks preeclampsia,

Language: Английский

Citations

789
Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2 DOI Creative Commons
Francesca Salamanna, Melania Maglio, Maria Paola Landini

et al.

Frontiers in Medicine, Journal Year: 2020, Volume and Issue: 7

Published: Dec. 3, 2020

The explosion of the new coronavirus (SARS-CoV-2) pandemic has brought role angiotensin converting enzyme 2 (ACE2) back into scientific limelight. Since SARS-CoV-2 must bind ACE2 for entering host cells in humans, its expression and body localization are critical to track potential target organ this infection outline disease progression clinical outcomes. Here, we mapped physiological distribution, expression, activities discussed correlations mutal interactions with disparate symptoms present patients at level different organs. We highlighted that despite during ACE2-expressing organs may become direct targets, leading severe pathological manifestations, subsequent multiple failures, exact mechanism through which acts these is still heavily debated. Further efforts, also considering a personalized approach aimed consider specific patient differences mutual ACE2-SARS-CoV-2 long-term health effects associated COVID-19 currently mandatory.

Language: Английский

Citations

256
Haemodialysis patients show a highly diminished antibody response after COVID-19 mRNA vaccination compared with healthy controls DOI Creative Commons

Benedikt Simon,

Harald Rubey,

Andreas Treipl

et al.

Nephrology Dialysis Transplantation, Journal Year: 2021, Volume and Issue: 36(9), P. 1709 - 1716

Published: May 14, 2021

Haemodialysis (HD) patients are exposed to a high risk due the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. They prone acquiring infection and threatened by mortality rates in case of infection. However, HD were not included efficacy trials SARS-CoV-2 vaccines. Such data would have been critical because show decreased responses against various other vaccines this could translate as well.We conducted prospective cohort study that contained group 81 80 healthy controls. All them had vaccinated with BioNTech/Pfizer mRNA vaccine (two doses, per manufacturer's recommendation). The anti-SARS-CoV-2 spike (S) antibody response was measured for all participants 21 days after second dose. groups compared using univariate quantile regressions multivariate analysis. adverse events (AEs) vaccination assessed via questionnaire. Finally, correlation between HBs-antibody established.The significantly lower S titres than control (median 171 U/mL dialysis 2500 controls). Further, presented fewer AEs group. No found previous Hepatitis B vaccine.HD present highly diminished Therefore, they be much less protected vaccinations expected. Further studies test alternative schemes should considered.

Language: Английский

Citations

151
The effect of maternal SARS-CoV-2 infection timing on birth outcomes: a retrospective multicentre cohort study DOI Creative Commons
Samantha N. Piekos, Ryan Roper, Yeon Mi Hwang

et al.

The Lancet Digital Health, Journal Year: 2022, Volume and Issue: 4(2), P. e95 - e104

Published: Jan. 14, 2022

The impact of maternal SARS-CoV-2 infection remains unclear. In this study, we evaluated the risk on birth outcomes and how is modulated by pregnancy trimester in which occurs. We also developed models to predict gestational age at delivery for people following a during pregnancy.

Language: Английский

Citations

110
Sexual dimorphism in COVID-19: potential clinical and public health implications DOI Open Access
Nicole Bechmann,

Andreas Barthel,

Andreas Schedl

et al.

The Lancet Diabetes & Endocrinology, Journal Year: 2022, Volume and Issue: 10(3), P. 221 - 230

Published: Feb. 1, 2022

Language: Английский

Citations

105
Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation DOI Creative Commons
Xia Chen, Rong Wu, Lei Li

et al.

Immunity, Journal Year: 2023, Volume and Issue: 56(2), P. 336 - 352.e9

Published: Feb. 1, 2023

Language: Английский

Citations

66
Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring DOI Creative Commons
Filippo Mirabella, Genni Desiato, Sara Mancinelli

et al.

Immunity, Journal Year: 2021, Volume and Issue: 54(11), P. 2611 - 2631.e8

Published: Nov. 1, 2021

Early prenatal inflammatory conditions are thought to be a risk factor for different neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy causes abnormal behavior in offspring, but whether these defects result from altered synaptic developmental trajectories remains unclear. Here we showed that transient IL-6 via injection into pregnant mice or developing embryos enhanced glutamatergic synapses and led overall brain hyperconnectivity offspring adulthood. activated synaptogenesis gene programs neurons required the transcription STAT3 expression of RGS4 gene. The STAT3-RGS4 pathway was also neonatal brains poly(I:C)-induced maternal immune activation, which mimics viral infection pregnancy. These findings indicate at early stages is sufficient exert long-lasting effect on connectivity, providing mechanistic framework association between events

Language: Английский

Citations

99
The Effects of COVID-19 on the Placenta During Pregnancy DOI Creative Commons

Habib Sadeghi Rad,

Joan Röhl, Nataly Stylianou

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Sept. 15, 2021

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a global pandemic. The virus primarily affects lungs where it induces distress ranging from mild to acute, however, there is growing body of evidence supporting its negative effects on other system organs that also carry ACE2 receptor, such as placenta. majority newborns delivered SARS-CoV-2 positive mothers test following delivery, suggesting are protective mechanisms within There appears be higher incidence pregnancy-related complications in mothers, miscarriage, restricted fetal growth, or still-birth. In this review, we discuss pathobiology COVID-19 maternal infection and potential adverse associated with viral infection, possibility transplacental transmission.

Language: Английский

Citations

86
Lack of effects on female fertility and prenatal and postnatal offspring development in rats with BNT162b2, a mRNA-based COVID-19 vaccine DOI Creative Commons
Christopher Bowman,

Marie Bouressam,

Sarah N. Campion

et al.

Reproductive Toxicology, Journal Year: 2021, Volume and Issue: 103, P. 28 - 35

Published: May 28, 2021

BNT162b2 is a vaccine developed to prevent coronavirus disease 2019 (COVID-19). lipid nanoparticle formulated nucleoside-modified messenger RNA (mRNA) encoding the severe acute respiratory syndrome 2 (SARS-CoV-2) spike protein locked in its prefusion conformation. A developmental and reproductive toxicity study was conducted rats according international regulatory guidelines. The full human dose of 30 μg mRNA/dose (>300 times on mg/kg basis) administered intramuscularly 44 female 21 14 days prior mating gestation 9 20. Half were subject cesarean section fetal examination at end gestation, other half allowed deliver monitored lactation. robust neutralizing antibody response confirmed presence antibodies also fetuses offspring. Nonadverse effects, related local injection site reaction, noted dams as expected from animal studies consistent with observations humans. There no effects performance, fertility, or any ovarian uterine parameters nor embryo-fetal postnatal survival, growth, physical development neurofunctional offspring through Together safety profile nonpregnant people, this ICH-compliant nonclinical data supports women childbearing potential pregnant lactating women.

Language: Английский

Citations

76
SARS-CoV-2 infection during pregnancy and pregnancy-related conditions: Concerns, challenges, management and mitigation strategies–a narrative review DOI Creative Commons
Rakesh Kumar,

Cut Meurah Yeni,

Niken Asri Utami

et al.

Journal of Infection and Public Health, Journal Year: 2021, Volume and Issue: 14(7), P. 863 - 875

Published: April 23, 2021

The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), is a global public health problem. SARS-CoV-2 triggers hyper-activation of inflammatory and immune responses resulting in cytokine storm increased on several organs like lungs, kidneys, intestine, placenta. Although affects individuals all age groups physiological statuses, immune-compromised such as pregnant women are considered highly vulnerable group. This review aims to raise the concerns high risk infection, morbidity mortality COVID-19 provides critical reviews pathophysiology pathobiology how infection potentially increases severity fatality during pregnancy. article also discussion current evidence vertical transmission pregnancy breastfeeding. Lastly, guidelines management, treatment, preventive, mitigation strategies pregnancy-related conditions delivery breastfeeding discussed.

Language: Английский

Citations

70