Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Feb. 17, 2023
Abstract
Rheumatoid
arthritis
(RA)
is
an
incurable
systemic
autoimmune
disease.
Disease
progression
leads
to
joint
deformity
and
associated
loss
of
function,
which
significantly
impacts
the
quality
life
for
sufferers
adds
losses
in
labor
force.
In
past
few
decades,
RA
has
attracted
increased
attention
from
researchers,
abnormal
signaling
pathways
are
a
very
important
research
field
diagnosis
treatment
RA,
provides
evidence
understanding
this
complex
disease
developing
novel
RA-linked
intervention
targets.
The
current
review
intends
provide
comprehensive
overview
including
general
introduction
disease,
historical
events,
epidemiology,
risk
factors,
pathological
process,
highlight
primary
progress
various
molecular
mechanisms,
genetic
epigenetic
summarize
most
recent
developments
identifying
new
inhibitors
treating
RA.
therapeutic
interventions
approved
drugs,
clinical
pre-clinical
cutting-edge
technologies.
These
will
hopefully
drive
strategically
targeted
therapies
hope
ideas
options
future.
EBioMedicine,
Journal Year:
2018,
Volume and Issue:
35, P. 345 - 360
Published: Aug. 29, 2018
Background
and
aimsDefective
autophagy
has
been
proposed
as
an
important
event
in
a
growing
number
of
autoimmune
inflammatory
diseases
such
rheumatoid
arthritis
lupus.
However,
the
precise
role
mechanistic
target
rapamycin
(mTOR)-dependent
its
underlying
regulatory
mechanisms
intestinal
epithelium
response
to
inflammation
oxidative
stress
remain
poorly
understood.MethodsThe
levels
p-mTOR,
LC3B,
p62
mice
LPS-treated
cells
were
examined
by
immunoblotting,
immunohistochemistry,
confocal
microscopy
transmission
electron
(TEM).
We
evaluated
expression
IL-1β,
IL-8,
TNF-α,
MDA,
SOD
T-AOC
quantitative
real
time-polymerase
chain
reaction
(qRT-PCR)
commercially
available
kits
after
silencing
mTOR
ATG5.
In
vivo
modulation
was
achieved
using
AZD8055,
3-methyladenine.
Finally,
verify
involvement
TLR4
signalling
NF-κB
pathway
active
ulcerative
colitis
(UC)
patients,
immunofluorescence,
qRT-PCR,
immunoblotting
TEM
performed
determine
relevance
inflammation.ResultsThe
mTOR-dependent
autophagic
flux
impairment
murine
model
colitis,
human
epithelial
UC
patients
is
probably
regulated
TLR4-MyD88-MAPK
pathway.
Silencing
remarkably
attenuated,
whereas
inhibiting
ATG5
aggravated,
LPS-induced
injury.
Pharmacological
administration
inhibitors
stimulators
markedly
ameliorated
experimental
vivo.ConclusionsOur
findings
not
only
shed
light
on
mechanism
autophagy,
but
also
provided
potential
therapeutic
targets
for
refractory
bowel
disease.
Neuropsychiatric Disease and Treatment,
Journal Year:
2015,
Volume and Issue:
unknown, P. 243 - 243
Published: Jan. 1, 2015
Abstract:
Amyloid-β
plaques
and
neurofibrillary
tangles
are
the
main
neuropathological
hallmarks
in
Alzheimer’s
disease
(AD),
most
common
cause
of
dementia
elderly.
However,
it
has
become
increasingly
apparent
that
neuroinflammation
plays
a
significant
role
pathophysiology
AD.
This
review
summarizes
current
status
research
related
to
AD,
focusing
on
connections
between
some
inflammation
factors
Among
these
connections,
we
discuss
dysfunctional
blood–brain
barrier
alterations
functional
responses
microglia
astrocytes
this
process.
In
addition,
summarize
intracellular
signaling
pathways
involved
inflammatory
microglia,
including
mitogen-activated
protein
kinase
pathways,
nuclear
factor-kappa
B
cascade,
peroxisome
proliferator–activated
receptor-gamma
transcription
factors.
Finally,
dysregulation
control
release
pro-
anti-inflammatory
cytokines
classic
AD
pathology
(amyloid
tangles)
is
also
reviewed.
Keywords:
inflammation,
barrier,
glial
cells,
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(6), P. 2187 - 2187
Published: March 22, 2020
Forest
trees
are
a
major
source
of
biogenic
volatile
organic
compounds
(BVOCs).
Terpenes
and
terpenoids
known
as
the
main
BVOCs
forest
aerosols.
These
have
been
shown
to
display
broad
range
biological
activities
in
various
human
disease
models,
thus
implying
that
aerosols
containing
these
may
be
related
beneficial
effects
bathing.
In
this
review,
we
surveyed
studies
analyzing
selected
most
abundant
23
terpenes
emitted
forested
areas
Northern
Hemisphere,
which
were
reported
anti-inflammatory
activities.
We
categorized
processes
functions
into
six
groups
summarized
their
molecular
mechanisms
action.
Finally,
among
compounds,
examined
therapeutic
potentials
12
effective
against
respiratory
inflammation,
atopic
dermatitis,
arthritis,
neuroinflammation
inflammatory
diseases.
conclusion,
updated
support
propose
potential
use
chemopreventive
agents
for
treating
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Feb. 17, 2023
Abstract
Rheumatoid
arthritis
(RA)
is
an
incurable
systemic
autoimmune
disease.
Disease
progression
leads
to
joint
deformity
and
associated
loss
of
function,
which
significantly
impacts
the
quality
life
for
sufferers
adds
losses
in
labor
force.
In
past
few
decades,
RA
has
attracted
increased
attention
from
researchers,
abnormal
signaling
pathways
are
a
very
important
research
field
diagnosis
treatment
RA,
provides
evidence
understanding
this
complex
disease
developing
novel
RA-linked
intervention
targets.
The
current
review
intends
provide
comprehensive
overview
including
general
introduction
disease,
historical
events,
epidemiology,
risk
factors,
pathological
process,
highlight
primary
progress
various
molecular
mechanisms,
genetic
epigenetic
summarize
most
recent
developments
identifying
new
inhibitors
treating
RA.
therapeutic
interventions
approved
drugs,
clinical
pre-clinical
cutting-edge
technologies.
These
will
hopefully
drive
strategically
targeted
therapies
hope
ideas
options
future.
