International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(9), P. 4413 - 4413
Published: April 23, 2021
Connexins
are
a
family
of
transmembrane
proteins
that
play
key
role
in
cardiac
physiology.
Gap
junctional
channels
put
into
contact
the
cytoplasms
connected
cardiomyocytes,
allowing
existence
electrical
coupling.
However,
addition
to
this
fundamental
role,
connexins
also
involved
cardiomyocyte
death
and
survival.
Thus,
chemical
coupling
through
gap
junctions
plays
spreading
injury
between
cells.
Moreover,
their
involvement
cell-to-cell
communication,
mounting
evidence
indicates
have
additional
junction-independent
functions.
Opening
unopposed
hemichannels,
located
at
lateral
surface
may
compromise
cell
homeostasis
be
ischemia/reperfusion
injury.
In
addition,
non-canonical
structures,
including
mitochondria
nucleus,
been
demonstrated
cardioprotection
regulation
growth
differentiation.
review,
we
will
provide,
first,
an
overview
on
connexin
biology,
synthesis
degradation,
interactions.
Then,
conduct
in-depth
examination
pathophysiology,
new
findings
regarding
myocardial
injury,
fibrosis,
gene
transcription
or
signaling
regulation.
Frontiers in Pharmacology,
Journal Year:
2013,
Volume and Issue:
4
Published: Jan. 1, 2013
Functional
interaction
between
neurons
and
glia
is
an
exciting
field
that
has
expanded
tremendously
during
the
past
decade.
Such
partnership
multiple
impacts
on
neuronal
activity
survival.
Indeed,
numerous
findings
indicate
glial
cells
interact
tightly
with
in
physiological
as
well
pathological
situations.
One
typical
feature
of
their
high
expression
level
gap
junction
protein
subunits,
named
connexins
(Cxs),
thus
membrane
channels
they
form
may
contribute
to
neuroglial
While
participation
neuroglia
interactions
been
regularly
reviewed
past,
other
channel
function
Cxs,
i.e.
hemichannels
located
at
cell
surface,
only
recently
received
attention.
provide
basis
for
a
unique
direct
cell-to-cell
communication,
Cx
allow
exchange
ions
signaling
molecules
cytoplasm
extracellular
medium,
supporting
autocrine
paracrine
communication
through
process
referred
"gliotransmission",
uptake
release
metabolites.
More
recently,
another
family
proteins,
termed
pannexins
(Panxs),
identified.
These
proteins
share
similar
topology
but
no
sequence
homology
Cxs.
They
multimeric
pharmacology
somewhat
overlapping
hemichannels.
duality
led
several
controversies
literature
concerning
identification
molecular
constituents
(Cxs
versus
Panxs)
glia.
In
present
review,
we
up-date
discuss
knowledge
Panx
glia,
properties
pharmacology,
understanding
contribution
healthy
diseased
brain.
Frontiers in Cellular Neuroscience,
Journal Year:
2018,
Volume and Issue:
11
Published: Jan. 16, 2018
Astrocytes
are
fundamental
players
in
the
regulation
of
synaptic
transmission
and
plasticity.
They
display
unique
morphological
phenotypical
features
that
allow
to
monitor
dynamically
respond
changes.
One
hallmarks
astrocytic
response
is
generation
calcium
elevations,
which
further
affect
downstream
cellular
processes.
Technical
advances
field
have
allowed
spatially
temporally
quantify
qualify
these
elevations.
However,
impact
on
brain
function
remains
poorly
understood.
In
this
review,
we
discuss
evidences
functional
heterogeneous
events
several
regions,
their
consequences
synapses,
circuits
behavior.
Cold Spring Harbor Perspectives in Biology,
Journal Year:
2019,
Volume and Issue:
11(4), P. a035063 - a035063
Published: Feb. 11, 2019
David
L.
Prole
and
Colin
W.
Taylor
Department
of
Pharmacology,
University
Cambridge,
Cambridge
CB2
1PD,
United
Kingdom
Correspondence:
cwt1000{at}cam.ac.uk
