Diabetes & Metabolism Journal,
Journal Year:
2021,
Volume and Issue:
45(3), P. 285 - 311
Published: March 29, 2021
The
relative
insufficiency
of
insulin
secretion
and/or
action
causes
diabetes.
However,
obesity
and
type
2
diabetes
mellitus
can
be
associated
with
an
absolute
increase
in
circulating
insulin,
a
state
known
as
hyperinsulinemia.
Studies
are
beginning
to
elucidate
the
cause-effect
relationships
between
hyperinsulinemia
numerous
consequences
metabolic
dysfunctions.
Here,
we
review
recent
evidence
demonstrating
that
may
play
role
inflammation,
aging
development
cancers.
In
this
review,
will
focus
on
mechanisms
excess
production
action,
placing
findings
have
challenged
dogma
context
existing
body
literature.
Where
relevant,
elaborate
specific
signal
transduction
components
actions
chronic
By
discussing
involvement
various
other
diseases,
identify
more
effective
therapeutics
or
lifestyle
interventions
for
preventing
treating
obesity,
cancer.
We
also
seek
pertinent
questions
ripe
future
investigation.
Diabetes Care,
Journal Year:
2016,
Volume and Issue:
39(2), P. 179 - 186
Published: Jan. 12, 2016
The
current
classification
system
presents
challenges
to
the
diagnosis
and
treatment
of
patients
with
diabetes
mellitus
(DM),
in
part
due
its
conflicting
confounding
definitions
type
1
DM,
2
latent
autoimmune
adults
(LADA).
schema
also
lacks
a
foundation
that
readily
incorporates
advances
our
understanding
disease
treatment.
For
appropriate
coherent
therapy,
we
propose
an
alternate
system.
β-cell-centric
DM
is
new
approach
obviates
inherent
unintended
confusions
model
presupposes
all
originates
from
final
common
denominator-the
abnormal
pancreatic
β-cell.
It
recognizes
interactions
between
genetically
predisposed
β-cells
number
factors,
including
insulin
resistance
(IR),
susceptibility
environmental
influences,
immune
dysregulation/inflammation,
lead
range
hyperglycemic
phenotypes
within
spectrum
DM.
Individually
or
concert,
often
self-perpetuating,
these
factors
contribute
β-cell
stress,
dysfunction,
loss
through
at
least
11
distinct
pathways.
Available,
yet
underutilized,
treatments
provide
rational
choices
for
personalized
therapies
target
individual
mediating
pathways
hyperglycemia
work
any
given
patient,
without
risk
drug-related
hypoglycemia
weight
gain
imposing
further
burden
on
β-cells.
This
article
issues
urgent
call
review
toward
consensus
new,
more
useful
Frontiers in Genetics,
Journal Year:
2019,
Volume and Issue:
10
Published: Feb. 28, 2019
Cancer
is
a
multistep
disease
driven
by
the
activation
of
specific
oncogenic
pathways
concomitantly
with
loss
function
tumor
suppressor
genes
that
act
as
sentinels
to
control
physiological
growth.
The
conservation
most
these
signaling
in
Drosophila,
and
ability
easily
manipulate
them
genetically,
has
made
fruit
fly
useful
model
organism
study
cancer
biology.
In
this
review
we
outline
basic
mechanisms
conserved
between
humans
flies
responsible
inducing
uncontrolled
growth
development.
Second,
describe
classic
novel
Drosophila
models
used
different
cancers,
objective
discuss
their
strengths
limitations
on
use
identify
signals
driving
cell
autonomously
within
organs,
drug
discovery
for
therapeutic
approaches.
The Cancer Journal,
Journal Year:
2021,
Volume and Issue:
27(1), P. 8 - 16
Published: Jan. 1, 2021
Abstract
Triple-negative
breast
cancer
accounted
for
12%
of
cancers
diagnosed
in
the
United
States
from
2012
to
2016,
with
a
5-year
survival
8%
16%
lower
than
hormone
receptor–positive
disease.
However,
preventive
and
screening
strategies
remain
tailored
demographics
less
lethal
luminal
cancers.
This
review
examines
ethnic,
genetic,
modifiable
risk
factors
associated
triple-negative
cancer,
which
providers
must
recognize
address
societal
disparities
this
deadly
Most
notable
is
that
disproportionately
affect
African
American
women
carriers
germline
BRCA
PALB2
mutations.
Even
controlling
treatment
delays,
stage,
socioeconomic
factors,
Americans
nearly
twice
as
likely
die
their
To
level
playing
field,
we
integrate
genomic
predictors
disease
epidemiologic
characteristics
molecular
subtypes
provide
personalized
assessment,
screening,
each
patient.
Journal of Clinical Oncology,
Journal Year:
2016,
Volume and Issue:
34(35), P. 4261 - 4269
Published: Dec. 10, 2016
Purpose
Type
2
diabetes
mellitus
(T2DM)
is
becoming
increasingly
prevalent
worldwide.
Epidemiologic
data
suggest
that
T2DM
associated
with
an
increased
incidence
and
mortality
from
many
cancers.
The
purpose
of
this
review
to
discuss
the
links
between
cancer,
effects
various
antidiabetic
medications
on
cancer
mortality,
anticancer
therapies
diabetes.
Design
This
study
a
preclinical
clinical
regarding
glucose
homeostasis.
Results
risk
greater
types.
Metformin
use
has
been
decrease
in
there
are
ongoing
randomized
trials
investigating
metformin
cancer-related
outcomes.
However,
association
other
antidiabetes
conflicting.
Glucocorticoids,
hormone-based
therapies,
inhibitors
target
phosphatidylinositol
3-kinase-Akt-mammalian
rapamycin
pathway,
insulin-like
growth
factor
1
receptor–targeted
therapy
have
high
rates
hyperglycemia.
These
agents
mediate
their
deleterious
metabolic
by
reducing
insulin
secretion
increasing
resistance
peripheral
tissues.
Conclusion
Studies
must
be
performed
optimize
screening
strategies
individuals
T2DM.
A
understanding
mechanisms
link
needed
identify
targets
for
who
develop
cancer.
Data
studies
further
elucidate
progression.
As
several
alter
homeostasis,
physicians
need
aware
these
potential
effects.
Careful
patient
monitoring
during
treatment
necessary.
Endocrinology,
Journal Year:
2018,
Volume and Issue:
159(11), P. 3801 - 3812
Published: Sept. 12, 2018
The
rates
of
obesity
and
diabetes
are
increasing
worldwide,
whereas
the
age
onset
for
both
decreasing
steadily.
Obesity
associated
with
multiple
factors
that
contribute
to
increased
risk
a
number
different
cancers,
including
breast
cancer.
These
hyperinsulinemia,
elevated
IGFs,
hyperglycemia,
dyslipidemia,
adipokines,
inflammatory
cytokines,
gut
microbiome.
In
this
review,
we
discuss
current
understanding
complex
signaling
pathways
underlying
these
involved
in
obesity/diabetes-breast
cancer
link,
focus
particularly
on
roles
insulin/IGF
system
dyslipidemia
preclinical
models.
We
review
some
therapeutic
strategies
target
metabolic
derangements
Future
research
directions
potential
also
discussed.
European Journal of Heart Failure,
Journal Year:
2019,
Volume and Issue:
21(12), P. 1515 - 1525
Published: July 18, 2019
Emerging
evidence
supports
that
cancer
incidence
is
increased
in
patients
with
cardiovascular
(CV)
disease
and
heart
failure
(HF),
HF
frequently
die
from
cancer.
Recently,
data
have
been
generated
showing
circulating
factors
relation
to
promote
tumour
growth
development
murine
models,
providing
proof
a
causal
relationship
exists
between
both
diseases.
Several
common
pathophysiological
mechanisms
linking
exist,
include
inflammation,
neuro‐hormonal
activation,
oxidative
stress
dysfunctional
immune
system.
These
shared
mechanisms,
combination
risk
factors,
concert
may
explain
why
are
prone
develop
Investigating
the
new
insights
rapidly
becoming
an
exciting
field
of
research,
we
herein
review
most
recent
data.
Besides
call
for
clinical
awareness,
essential
optimize
treatment
strategies
having
developed
history
HF.
Finally,
ongoing
future
trials
should
strive
comprehensive
phenotyping
CV
end
points,
allow
optimal
usefulness
data,
better
describe
understand
characteristics
these
two
lethal
