Differentiating Lung Adenocarcinoma from Tuberculous Nodules in HIV/AIDS Patients Using Preoperative CT-Based Intratumoral and Peritumoral Radiomics Combined with Clinical Features

Journal of Multidisciplinary Healthcare, Journal Year: 2025, Volume and Issue: Volume 18, P. 2693 - 2706

Published: May 1, 2025

Language: Английский

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Chronic obstructive pulmonary disease in HIV

Expert Review of Respiratory Medicine, Journal Year: 2020, Volume and Issue: 15(1), P. 71 - 87

Published: Nov. 10, 2020

Introduction: Chronic obstructive pulmonary disease (COPD) is more prevalent in people with HIV (PWH) than the general population and leads to an increased burden of morbidity mortality this population. The mechanisms behind COPD development progression PWH are not fully elucidated, there no PWH-specific guidelines for management. Areas covered: goal broad narrative review epidemiology globally, highlight proposed pathways contributing prevalence PWH, discuss structural functional changes lungs population, assesses excess comorbidities COPD, address management practices unique Expert opinion: Understanding how a chronic viral infection independent cigarette smoking, critical scientific importance. Further research should focus on pathophysiology interaction between determine role disease-modifying risk factors such as opportunistic pneumonia air pollution, well generate data from randomized clinical trials safety efficacy specific therapies vulnerable patient

Language: Английский

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Clinical and laboratory specific parameters of COVID-19 in patients with TB/HIV co-infection

Tuberculosis and lung diseases, Journal Year: 2022, Volume and Issue: 100(4), P. 14 - 21

Published: May 14, 2022

The objective: to study clinical and laboratory specific parameters of the COVID-19 course in patients with TB/HIV co-infection, analyze changes lungs caused by pulmonary tuberculosis concurrent HIV infection. Subjects Methods. 68 HIV-infected aged 18-66 years old were included study, they all admitted Novosibirsk State Regional Clinical Tuberculosis Hospital, Novosibirsk, confirmed from May 2020 2021. manifestations, CD4 count RNA level, presence secondary infections assessed. Results. In severe profound immunodeficiency, coronavirus infection was more often mild moderate, immunocompetent – moderate severe. However, immunodeficiency at greater risk an adverse outcome due lymphohematogenic progression opportunistic infections. Conclusion. When diagnosing treating comorbid tuberculosis, it is important consider form + count.

Language: Английский

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Lung Function in Women With and Without Human Immunodeficiency Virus

Clinical Infectious Diseases, Journal Year: 2022, Volume and Issue: 76(3), P. e727 - e735

Published: May 23, 2022

Abstract Background Prior studies have found that human immunodeficiency virus (HIV) infection is associated with impaired lung function and increased risk of chronic disease, but few included large numbers women. In this study, we investigate whether HIV differences in Methods This was a cross-sectional analysis participants the Women’s Interagency Study, racially ethnically diverse multicenter cohort women without HIV. 2018–2019, at 9 clinical sites were invited to perform spirometry. Single-breath diffusing capacity for carbon monoxide (DLCO) also measured selected sites. The primary outcomes post-bronchodilator forced expiratory volume 1 second (FEV1) DLCO. Multivariable regression modeling used analyze association after adjustment confounding exposures. Results FEV1 measurements from 1489 (1062 HIV, 427 HIV) DLCO 671 (463 208 met standards quality reproducibility. There no significant difference between Women had lower (adjusted difference, –0.73 mL/min/mm Hg; 95% confidence interval, −1.33 −.14). Among nadir CD4 + cell counts hepatitis C measurements. Conclusions respiratory gas exchange decreased exchange.

Language: Английский

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Koala retrovirus load and non-A subtypes are associated with secondary disease among wild northern koalas

PLoS Pathogens, Journal Year: 2022, Volume and Issue: 18(5), P. e1010513 - e1010513

Published: May 19, 2022

Koala Retrovirus (KoRV) has been associated with neoplasia in the vulnerable koala (Phascolarctos cinereus). However, there are conflicting findings regarding its association secondary disease. We undertook a large-scale assessment of how different KoRV subtypes and viral load Chlamydia pecorum infection range disease pathologies 151 wild koalas admitted for care to Currumbin Wildlife Hospital, Australia. Viral (KoRV pol copies per ml plasma) was best predictor more than any other variable. The predicted probability having symptoms increased from 25% over 85% across observed load, while C. 40% 80%. found negative correlation between proportion env deep sequencing reads that were endogenous KoRV-A total load. This is consistent suppression KoRV-A, exogenous obtain high levels. Additionally, we reveal evidence directly disease, sequence overall after effect accounted for. Further, positive KoRV-D or KoRV-D/F likely have urogenital low body condition score, respectively, irrespective By contrast, our do not support previous KoRV-B particular Chlamydial Based on these suggest research conservation programs should target understanding what drives individual differences limiting subtype diversity within populations, rather seeking eliminate subtype.

Language: Английский

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