The implications of removing race from interpretation of pulmonary function among persons with or without HIV DOI
Richard J. Wang, Ken M. Kunisaki,

Alison Morris

et al.

JAIDS Journal of Acquired Immune Deficiency Syndromes, Journal Year: 2024, Volume and Issue: 98(4), P. 395 - 400

Published: Dec. 3, 2024

Studies suggest that the use of race-specific pulmonary function reference equations may obscure racial inequities in respiratory health. Whether removing race from interpretation would influence analyses HIV and is unknown. Pulmonary measurements 1,067 men (591 with HIV) Multicenter AIDS Cohort Study (MACS) 1,661 women (1,175 Women's Interagency (WIHS) were analyzed. Percent-of-predicted values for spirometry single-breath diffusing capacity carbon monoxide (DLCO) generated derived National Health Nutrition Examination Survey race-neutral application Global Lung Function Initiative database. Regression models used to evaluate association between percent-of-predicted measures function. Alpaydin's F test was compare how well these predicted self-reported health-related quality life. Persons observed have significantly lower DLCO than those without but no significant differences spirometric function, regardless whether a or approach used. Among men, not women, generate performed better predicting respiratory-related The continues identify lung impairment persons at risk and, DLCO, be superior identifying clinically relevant impairments.

Language: Английский

HIV-associated lung disease DOI
Ioannis Konstantinidis, Kristina Crothers, Ken M. Kunisaki

et al.

Nature Reviews Disease Primers, Journal Year: 2023, Volume and Issue: 9(1)

Published: July 27, 2023

Language: Английский

Citations

19
Effect of HIV on Lung Function and Structure: A Systematic Review and Meta-analysis DOI
Ioannis Konstantinidis, Richard H. Zou, Spyridon N. Papageorgiou

et al.

Annals of the American Thoracic Society, Journal Year: 2024, Volume and Issue: 22(2), P. 274 - 284

Published: Oct. 17, 2024

Rationale: Obstructive lung disease (OLD) pathogenesis includes inhalational (e.g., smoking) and noninhalational mechanisms infections). Human immunodeficiency virus (HIV) has been suggested as a novel OLD risk factor. Substantial data have recently emerged about its effects on function structure, especially in low- to middle-income countries regarding longitudinal function. Objectives: To assess the association of HIV infection with OLD, impaired gas exchange, emphysema. Methods: In this systematic review meta-analysis, we searched PubMed, Embase, Cochrane Central Register Controlled Trials, Database Systematic Reviews, Web Science, Scopus, Cumulative Index Nursing Allied Health Literature, Global Medicus through April 2023 for controlled observational studies people living without reporting pulmonary and/or Primary outcomes were by spirometry, exchange impairment diffusing capacity carbon monoxide, visual emphysema computed tomography. We performed random-effects meta-analyses using odds ratios (ORs) 95% confidence intervals (CIs). This study was registered PROSPERO (CRD42021268498). Results: included 95 publications pertaining 43 unique studies. associated (OR, 1.29; CI, 1.02-1.63), 2.63; 0.96-7.24), 1.46; 1.02-2.09), faster decline. greatest Africans HIV. There no or from Africa. The certainty evidence low very low, primarily because studies' design. Conclusions: People increased impairment, decline, varies regionally. recommend that both spirometry monoxide be measured respiratory symptoms. Future should develop validate HIV-specific screening case-finding strategies chronic disease.

Language: Английский

Citations

2
Association of SARS‐CoV‐2 Infection and Cardiopulmonary Long COVID With Exercise Capacity and Chronotropic Incompetence Among People With HIV DOI Creative Commons
Matthew S. Durstenfeld, Michael J. Peluso, Matthew A. Spinelli

et al.

Journal of the American Heart Association, Journal Year: 2023, Volume and Issue: 12(20)

Published: Oct. 13, 2023

Background Postacute sequelae of COVID-19 (PASC) and HIV are both associated with reduced exercise capacity, but whether SARS-CoV-2 or PASC capacity among people (PWH) is unknown. We hypothesized that PWH would have from chronotropic incompetence. Methods Results conducted cross-sectional cardiopulmonary testing within a COVID recovery cohort included without prior infection (controls). evaluated associations HIV, SARS-CoV-2, (peak oxygen consumption) chronotropy (adjusted heart rate reserve). 83 participants (median age, 54 years; 35% women; 37 PWH): 23 out (62%) all 46 controls had infection, 11 (48%) 28 (61%) PASC. Peak consumption was versus (80% predicted 99%,

Language: Английский

Citations

5
COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies DOI Creative Commons
K.L. Byanova, R. Abelman, Crystal M. North

et al.

International Journal of COPD, Journal Year: 2023, Volume and Issue: Volume 18, P. 2795 - 2817

Published: Nov. 1, 2023

Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by airflow limitation and persistent symptoms. People with HIV (PWH) are particularly vulnerable to COPD development; PWH have demonstrated both higher rates of an earlier more rapid decline in lung function than their seronegative counterparts, even after accounting for differences cigarette smoking. Factors contributing this HIV-associated difference include chronic immune activation inflammation, accelerated aging, predilection infections, alterations the microbiome, interplay between inhalational toxins. In review, we discuss what known about epidemiology pathobiology among outline screening, diagnostic, prevention, treatment strategies.

Language: Английский

Citations

4
Sex modifies the risk of HIV-associated obstructive lung disease in Ugandans postpneumonia DOI
R. Abelman, Jessica Fitzpatrick,

Josephine Zawedde

et al.

AIDS, Journal Year: 2023, Volume and Issue: unknown

Published: June 20, 2023

Objectives: Spirometric abnormalities are frequent and obstructive lung disease (OLD) is a common comorbidity among people with HIV (PWH). increases the risk of many comorbidities to greater degree in women than men. Few studies have evaluated whether sex modifies HIV-associated OLD. Design Methods: To evaluate associations between abnormal function, men without underwent spirometric testing after completing therapy for pneumonia, including tuberculosis (TB), Kampala, Uganda. OLD was defined as post-bronchodilator forced expiratory volume first second vital capacity (FEV 1 /FVC) ratio <0.70. Associations sex, HIV, function were using multivariable regression models sex-by-HIV interaction terms adjusting age, body mass index (BMI), smoking status, TB status. Results: Among 348 participants, 147 (42%) 135 (39%) positive. Sixteen (11%) 23 had The HIV-sex significant (p = 0.04). In adjusted stratified analysis, 3.44 (95% CI 1.11, 12.0; p 0.04) increased odds having compared HIV. Women did not Conclusions: appears increase an urban Ugandan setting. mechanistic explanation this by remains unclear warrants further study.

Language: Английский

Citations

3
Isolated abnormal diffusing capacity for carbon monoxide (iso↓DLco) is associated with increased respiratory symptom burden in people with HIV infection DOI Creative Commons
K.L. Byanova, Jessica Fitzpatrick, Amanda Jan

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(7), P. e0288803 - e0288803

Published: July 18, 2023

Objectives An isolated reduction in the diffusing capacity for carbon monoxide (DLco; iso↓DLco) is one of most common pulmonary function test (PFT) abnormalities people living with HIV (PWH), but its clinical implications are incompletely understood. In this study, we explored whether iso↓DLco PWH associated a greater respiratory symptom burden. Study design Cross-sectional analysis Methods We used ATS/ERS compliant PFTs from normal spirometry (post-bronchodilator FEV1/FVC ≥0.7; FEV1, FVC ≥80% predicted) I AM OLD cohort San Francisco, CA and Seattle, WA, grouped by DLco categorized as (DLco ≥lower limit normal, LLN), mild (LLN >DLco >60% predicted), moderate-severe ≤60% predicted). performed multivariable analyses to associations between validated symptom-severity quality life questionnaires, including modified Medical Research Council dyspnea scale (mMRC), COPD Assessment Test (CAT), St. George’s Respiratory Questionnaire (SGRQ), well individual CAT symptoms. Results Mild was only significantly higher SGRQ score. Moderate-severe odds mMRC ≥2 scores. had increased breathlessness, decreased activity, lower confidence leaving home, less energy. Conclusions Iso↓DLco worse scores, association becomes stronger worsening DLco, suggesting that impaired gas exchange alone has significant negative impact on PWH. Additional studies ongoing understand etiology finding appropriate interventions.

Language: Английский

Citations

2
Association of SARS-CoV-2 Infection and Cardiopulmonary Long COVID with Exercise Capacity and Chronotropic Incompetence among People with HIV DOI Open Access
Matthew S. Durstenfeld, Michael J. Peluso, Matthew A. Spinelli

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 2, 2023

Long COVID has been associated with reduced exercise capacity, but whether SARS-CoV-2 infection or is capacity among people HIV (PWH) not reported. We hypothesized that PWH cardiopulmonary post-acute symptoms of COVID-19 (PASC) would have due to chronotropic incompetence.

Language: Английский

Citations

1
Response to: ‘No long-term effect of past Pneumocystis jirovecii pneumonia on pulmonary function in people with HIV’ DOI
K.L. Byanova, Laurence Huang

AIDS, Journal Year: 2023, Volume and Issue: 37(14), P. 2267 - 2268

Published: Oct. 25, 2023

aDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine bDivision HIV, Infectious Diseases Global Medicine, University California San Francisco, California, USA. Correspondence to Katerina L. Byanova, MD, MS, Division 505 Parnassus Ave, Box 0111, CA 94143, E-mail: [email protected] Received 21 July, 2023 Accepted 9 August,

Language: Английский

Citations

1
Influence of Impaired Diffusing Capacity and Sleep-disordered Breathing on Nocturnal Hypoxemia and Health Outcomes in Men with and without Human Immunodeficiency Virus DOI
Sarath Raju, Trishul Siddharthan, Meredith C. McCormack

et al.

Annals of the American Thoracic Society, Journal Year: 2024, Volume and Issue: 21(7), P. 1085 - 1093

Published: March 18, 2024

Rationale: Nocturnal hypoxemia is common in sleep-disordered breathing (SDB) and associated with increased morbidity mortality. Although impaired diffusing capacity of the lung for carbon monoxide (DlCO) daytime hypoxemia, its influence on SDB-related nocturnal not known. Objectives: To characterize effects DlCO impairment health outcomes. Methods: Data from a multicenter cohort men without human immunodeficiency virus (HIV) infection, concomitant measures home-based polysomnography (n = 544), were analyzed. Multivariable quantile regression models characterized associations between several (e.g., total sleep time oxygen saturation as measured by pulse oximetry [SpO2] < 90% [T90]). Structural equation used to assess prevalent hypertension type 2 diabetes. Results: (<80% predicted) was sleep-related hypoxemia. Participants severe SDB (apnea-hypopnea index ⩾ 30 events/h) had higher T90 (median difference, 15.0% [95% confidence interval (CI), 10.3% 19.7%]) average desaturation 1.0 CI, 0.5 1.5]) lower nadir SpO2 -8.2% -11.4% -4.9%]) during -1.1% -2.1% -0.01%]) than those preserved DlCO. Higher adjusted odds (odds ratio, 1.39 1.14 1.70]) diabetes 1.25 1.07 1.46]). Conclusions: hypertension, Assessment should be considered guide testing risk stratification strategies.

Language: Английский

Citations

0
Hepatitis C Virus Clearance and Diffusing Capacity for Carbon Monoxide in Women With and Without Human Immunodeficiency Virus DOI Creative Commons

A. Curnow,

Laurence Huang, Margaret A. Fischl

et al.

Open Forum Infectious Diseases, Journal Year: 2024, Volume and Issue: 11(5)

Published: April 26, 2024

Abstract Hepatitis C virus (HCV) infection is associated with extrahepatic effects, including reduced diffusing capacity of the lungs. It unknown whether clearance HCV improved capacity. In this sample women and without human immunodeficiency virus, there was no association between

Language: Английский

Citations

0