Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

British Journal of Pharmacology, Journal Year: 2016, Volume and Issue: 174(11), P. 1325 - 1348

Published: Sept. 17, 2016

Curcumin, a yellow pigment in the Indian spice Turmeric (Curcuma longa), which is chemically known as diferuloylmethane, was first isolated exactly two centuries ago 1815 by German Scientists, Vogel and Pelletier. However, according to pubmed database, study on its biological activity an antibacterial agent published 1949 Nature clinical trial reported The Lancet 1937. Although current database indicates almost 9000 publications curcumin, until 1990 there were less than 100 papers this nutraceutical. At molecular level, multitargeted has been shown exhibit anti-inflammatory through suppression of numerous cell signalling pathways including NF-κB, STAT3, Nrf2, ROS COX-2. Numerous studies have indicated that curcumin highly potent antimicrobial be active against various chronic diseases types cancers, diabetes, obesity, cardiovascular, pulmonary, neurological autoimmune diseases. Furthermore, compound also synergistic with other nutraceuticals such resveratrol, piperine, catechins, quercetin genistein. To date, over different trials completed clearly show safety, tolerability effectiveness humans. more populations are necessary prove potential This review's primary focus lessons learnt about from trials.

Language: Английский

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Antidiabetic Potential of Medicinal Plants and Their Active Components

Biomolecules, Journal Year: 2019, Volume and Issue: 9(10), P. 551 - 551

Published: Sept. 30, 2019

Diabetes mellitus is one of the major health problems in world, incidence and associated mortality are increasing. Inadequate regulation blood sugar imposes serious consequences for health. Conventional antidiabetic drugs effective, however, also with unavoidable side effects. On other hand, medicinal plants may act as an alternative source agents. Examples potential described, focuses on preclinical clinical studies. The beneficial each plant matrix given by combined concerted action their profile biologically active compounds.

Language: Английский

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Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

Molecules, Journal Year: 2015, Volume and Issue: 20(5), P. 9183 - 9213

Published: May 20, 2015

It is extensively verified that continued oxidative stress and damage may lead to chronic inflammation, which in turn can mediate most diseases including cancer, diabetes, cardiovascular, neurological, inflammatory bowel disease pulmonary diseases. Curcumin, a yellow coloring agent extracted from turmeric, shows strong anti-oxidative anti-inflammatory activities when used as remedy for the prevention treatment of How activates pathways leading progression focus this review. Thus, research date suggests stress, are closely linked, antioxidant properties curcumin play key role inflammation

Language: Английский

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The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

Food and Chemical Toxicology, Journal Year: 2015, Volume and Issue: 83, P. 111 - 124

Published: June 13, 2015

Language: Английский

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Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies

Biomedicine & Pharmacotherapy, Journal Year: 2016, Volume and Issue: 85, P. 102 - 112

Published: Dec. 5, 2016

Language: Английский

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Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review

Phytotherapy Research, Journal Year: 2018, Volume and Issue: 32(6), P. 985 - 995

Published: Feb. 26, 2018

Curcumin is the major constituent of turmeric ( Curcuma longa ). Turmeric has been widely used as a spice in foods and for therapeutic applications such anti‐inflammatory, antihyperlipidemic, antimicrobial activities. curcumin are nonmutagenic nongenotoxic. Oral use did not have reproductive toxicity animals at certain doses. Studies on human show toxic effects, was safe dose 6 g/day orally 4–7 weeks. However, some adverse effects gastrointestinal upsets may occur. Moreover, oral bioavailable formulations were 500 mg two times day 30 days, but there still few trials more studies needed specially nanoformulations it should be discussed separate article. In addition, known generally recognized substance. This review discusses safety medicine. nontoxic especially administration. also animals. They pregnancy needed.

Language: Английский

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Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

Critical Reviews in Food Science and Nutrition, Journal Year: 2019, Volume and Issue: 60(6), P. 887 - 939

Published: Jan. 11, 2019

Curcumin is a naturally occurring polyphenolic compound present in rhizome of Curcuma longa belonging to the family zingiberaceae. Growing experimental evidence revealed that curcumin exhibit multitarget biological implications signifying its crucial role health and disease. The current review highlights recent progress mechanisms underlying wide range pharmacological effects against numerous diseases like neuronal, cardiovascular, metabolic, kidney, endocrine, skin, respiratory, infectious, gastrointestinal cancer. ability modulate functions multiple signal transductions are linked with attenuation acute chronic diseases. Numerous preclinical clinical studies have modulates several molecules cell transduction pathway including PI3K, Akt, mTOR, ERK5, AP-1, TGF-β, Wnt, β-catenin, Shh, PAK1, Rac1, STAT3, PPARγ, EBPα, NLRP3 inflammasome, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 MyD-88. has potential prevent and/or manage various due anti-inflammatory, anti-oxidant anti-apoptotic properties an excellent safety profile. In contrast, anti-cancer reflected induction growth arrest apoptosis premalignant malignant cells. This also carefully emphasized pharmacokinetics interaction other drugs. Clinical shown safe at doses 12 g/day but exhibits poor systemic bioavailability. use adjuvant piperine, liposomal curcumin, nanoparticles phospholipid complex enhanced bioavailability therapeutic potential. Further warranted prove ailments.

Language: Английский

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Therapeutic and Medicinal Uses of Terpenes

Springer eBooks, Journal Year: 2019, Volume and Issue: unknown, P. 333 - 359

Published: Jan. 1, 2019

Language: Английский

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Dietary polyphenols as antidiabetic agents: Advances and opportunities

Food Frontiers, Journal Year: 2020, Volume and Issue: 1(1), P. 18 - 44

Published: March 1, 2020

Abstract Dietary polyphenols have been widely investigated as antidiabetic agents in cell, animals, human study, and clinical trial. The number of publication (Indexed by Web Science) on “polyphenols diabetes” significantly increased since 2010. This review highlights the advances opportunities dietary agents. prevent manage Type 2 diabetes mellitus via insulin‐dependent approaches, for instance, protection pancreatic islet β‐cell, reduction β‐cell apoptosis, promotion proliferation, attenuation oxidative stress, activation insulin signaling, stimulation pancreas to secrete insulin, well insulin‐independent approaches including inhibition glucose absorption, digestive enzymes, regulation intestinal microbiota, modification inflammation response, formation advanced glycation end products. Moreover, ameliorate diabetic complications, such vascular dysfunction, nephropathy, retinopathy, neuropathy, cardiomyopathy, coronary diseases, renal failure, so on. structure–activity relationship is still not clear. individual flavonoid or isoflavone has no therapeutic effect patients, although data are very limited. Resveratrol, curcumin, anthocyanins showed activity study. How hyperglycemia influences bioavailability bioactivity understood. An understanding how alters will lead an improvement their benefits outcomes.

Language: Английский

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In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature

Biomedicine & Pharmacotherapy, Journal Year: 2018, Volume and Issue: 109, P. 1085 - 1099

Published: Nov. 6, 2018

Quercetin, a typical flavonoid, possesses diverse biochemical and physiological actions, including antiplatelet, estrogenic, anti-inflammatory properties. This review mainly centers on recent ten years findings with respect to intervening diabetes its complications the well-known flavonoid quercetin. After short introduction of quercetin, major in vitro vivo are summarized showing that quercetin is promising molecule for treatment these diseases. Finally, we contemplate future development application prospects Despite wealth animal research results suggesting anti-diabetic potential efficacy diabetic human subjects yet be explored. The problem may become an important direction research.

Language: Английский

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