Recent Update on the Anti-Inflammatory Activities of Propolis

Molecules, Journal Year: 2022, Volume and Issue: 27(23), P. 8473 - 8473

Published: Dec. 2, 2022

In recent years, research has demonstrated the efficacy propolis as a potential raw material for pharmaceuticals and nutraceuticals. There is limited report detailing mechanisms of action its bioactive compounds in relation to their anti-inflammatory properties. Thus, aim present review examine latest experimental evidence (2017–2022) regarding properties propolis. A systematic scoping methodology was implemented. After applying exclusion criteria, total 166 publications were identified retrieved from Scopus, Web Science, Pubmed. Several key themes related subsequently identified, namely cancers, oral health, metabolic syndrome, organ toxicity inflammation, immune system, wound healing, pathogenic infections. Based on evidence, possess various modulating inflammation towards regulatory balance environment. general, we summarize that acts an substance by inhibiting downregulating TLR4, MyD88, IRAK4, TRIF, NLRP inflammasomes, NF-κB, associated pro-inflammatory cytokines such IL-1β, IL-6, IFN-γ, TNF-α. Propolis also reduces migration cells macrophages neutrophils, possibly chemokines CXCL9 CXCL10.

Language: Английский

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A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(17), P. 9573 - 9573

Published: Aug. 24, 2022

Wound healing is a recovering process of damaged tissues by replacing dysfunctional injured cellular structures. Natural compounds for wound treatment have been widely used centuries. Numerous published works provided reviews natural applications, which separated the approaches based on different categories such as characteristics, bioactivities, and modes action. However, current studies provide that originated from only plants or animals. In this work, we comprehensive review sourced both animals target bioactivities to promote resolution. The were classified into four main groups (i.e., anti-inflammation, anti-oxidant, anti-bacterial, collagen promotion), mostly studied in literature 1992 2022. Those are listed tables readers search their origin, bioactivity, targeting phases healing. We also reviewed trend using

Language: Английский

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Introduction to Traditional Medicine and Their Role in Prevention and Treatment of Emerging and Re-Emerging Diseases

Biomolecules, Journal Year: 2022, Volume and Issue: 12(10), P. 1442 - 1442

Published: Oct. 9, 2022

Infectious diseases have been a threat to human health globally. The relentless efforts and research enabled us overcome most of the through use antiviral antibiotic agents discovered employed. Unfortunately, microorganisms capability adapt mutate over time resistance ensues. There are many challenges in treating infections such as failure respond therapeutic agents, which has led more chronic infections, complications, preventable loss life. Thus, multidisciplinary approach collaboration is warranted create potent, effective, versatile therapies prevent eradicate old newly emerging diseases. In recent past, natural medicine proven its effectiveness against various illnesses. Most pharmaceutical currently used can trace their origin products one way, shape, or form. full potential yet be realized, numerous resources not explored analyzed. This merits continuous support analysis ancient treatment systems explore employ them an alternative principal therapy.

Language: Английский

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Chemical Variability and Pharmacological Potential of Propolis as a Source for the Development of New Pharmaceutical Products

Molecules, Journal Year: 2022, Volume and Issue: 27(5), P. 1600 - 1600

Published: Feb. 28, 2022

This review aims to analyze propolis as a potential raw material for the development and manufacture of new health-promoting products. Many scientific publications were retrieved from Scopus, PubMed, Google Scholar databases via searching word "propolis". The different extraction procedures, key biologically active compounds, biological properties, therapeutic analyzed. It was concluded that possesses variety properties because very complex chemical composition mainly depends on plant species visited by bees bees. Numerous studies found versatile pharmacological activities propolis: antimicrobial, antifungal, antiviral, antioxidant, anticancer, anti-inflammatory, immunomodulatory, etc. In this review, are presented point view origin standardization purpose pharmaceutical products its base. revealed some types propolis, especially European contain flavonoids phenolic acids, which could be markers quality evaluation preparations. One more focus paper overview microorganisms' sensitivity further antimicrobial antioxidant treatment various infectious diseases with an emphasis illnesses oral cavity. established activity is quite significant, Gram-negative bacteria lipophilic viruses. present study also interest industry appropriate design standardized preparations such mouthwashes, toothpastes, drops, sprays, creams, ointments, suppositories, tablets, capsules, Moreover, regarded source isolation substances. Furthermore, can facilitate partially overcoming problem preparations, principal obstacle broader use in industry. Finally, area food nutritionally well-balanced results indicate deserves better studied promising effects connection locality collection, vegetation, methods, standardization.

Language: Английский

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Brazilian red propolis: phytochemical screening, antioxidant activity and effect against cancer cells

BMC Complementary and Alternative Medicine, Journal Year: 2015, Volume and Issue: 15(1)

Published: Oct. 14, 2015

The implementation of new public healthcare models that stimulate the use natural products from traditional medicine, as a so-called integrated refers to an approach best both conventional medicine and medicine. Propolis is widely used product by different ancient cultures known exhibit biological activities beneficial for health. large number studies conducted with propolis had shown its chemical composition differs function climate, plant diversity bee species plays important role on therapeutic properties. aim this study was analyse phytochemical profile ethanolic extract red (EEP) fractionation, antioxidant action EEP fractions hexane, cloroform ethyl acetate cytotoxic activity human tumour cell lines SF-295 (glioblastoma), OVCAR-8 (ovary) HCT-116 (colon).EEP obtained maceration absolute ethanol, then it concentrated in rotaevaporator up complete evaporation solvent. crude fractionated acetate, chloroform methanol they were subjected screening total phenolic compounds. Antioxidant done means 2,2-diphenyl-1-picryhydrazyl (DPPH) method. Biomarkers identified LC-Orbitrap-FTMS. To assess extract, cells exposed over 72 h. Cell viability assessed MTT assay. percentage growth inhibition (IC50) analysed non-linear regression, absorbance values various investigated concentrations one-factor analysis variance (ANOVA) followed Tukey's or Tamhane's tests (α = 0.05).The results using LC-Orbitrap-FTMS indicated presence phlobaphene tannins, catechins, chalcones, aurones, flavonones, flavonols, xanthones, pentacyclic triterpenoids guttiferones Brazilian propolis. liquid-liquid partitioning exhibited satisfactory percentages. (IC50 < 34.27 μg/mL) high levels cytotoxicity all tested when compared negative control.C-Orbitrap-FTMS useful establish has properties decreases substantially survival cells; thus, potential serve anticancer drug.

Language: Английский

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Review of the anticancer activities of bee products

Asian Pacific Journal of Tropical Biomedicine, Journal Year: 2014, Volume and Issue: 4(5), P. 337 - 344

Published: April 10, 2014

Bee products have long been used in traditional medicine. The raw materials, crude extracts and purified active compounds from them found to exhibit interesting bioactivities, such as antimicrobial, anti-inflammatory antioxidant activities. In addition, they widely the treatment of many immune-related diseases, well recent times tumors. product peptides induce apoptotic cell death vitro several transformed (cancer) human lines, including those derived renal, lung, liver, prostate, bladder lymphoid cancers. These bioactive natural may, therefore, prove be useful part a novel targeted therapy for some types cancer, prostate breast cancer. This review summarizes current knowledge regarding vivo potential selective bee against tumor cells.

Language: Английский

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Bacterial cellulose skin masks—Properties and sensory tests

Journal of Cosmetic Dermatology, Journal Year: 2017, Volume and Issue: 17(5), P. 840 - 847

Published: Sept. 29, 2017

Summary Background Bacterial cellulose (BC) is a versatile material produced by microorganisms in the form of membranous hydrogel, totally biocompatible, and endowed with high mechanical strength. Its water‐holding capacity based on its highly porous nanofibrillar structure allows BC to incorporate release substances very fast, thus being suitable for preparation skincare masks. Aims The characterization cosmetic masks membranes active cosmetics. Methods were prepared simple incorporation actives into membranes, used as swelling matrix. characterized Fourier transform infrared (FTIR), scanning electron microscopy (SEM), sensory tests, skin moisture tests volunteers. Results results revealed good performance BC, considered effective panel volunteers, specially adhesion (7.7 at score scale), improvement (the hydration effect increased 76% 75% volunteers that vegetable extract mask formulation [VEM]), or decrease (80% showed 32.6% using propolis [PEM] treatment), indicating nanofiber can be applications. Conclusion demonstrate an alternative support treatment.

Language: Английский

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The use of propolis in dentistry, oral health, and medicine: A review

Journal of Oral Biosciences, Journal Year: 2021, Volume and Issue: 63(1), P. 23 - 34

Published: Jan. 18, 2021

Language: Английский

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Systematic review of natural and miscellaneous agents, for the management of oral mucositis in cancer patients and clinical practice guidelines — part 2: honey, herbal compounds, saliva stimulants, probiotics, and miscellaneous agents

Supportive Care in Cancer, Journal Year: 2020, Volume and Issue: 28(5), P. 2457 - 2472

Published: Feb. 13, 2020

Language: Английский

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Experimental Evidence for Therapeutic Potentials of Propolis

Nutrients, Journal Year: 2021, Volume and Issue: 13(8), P. 2528 - 2528

Published: July 24, 2021

Propolis is produced by honeybees from materials collected plants they visit. It a resinous material having mixtures of wax and bee enzymes. also known as glue used bees building in their hives, for blocking holes cracks, repairing the combs strengthening thin borders. has been extensively since ancient times different purposes traditional human healthcare practices. The quality composition propolis depend on its geographic location, climatic zone local flora. New Zealand Brazilian green are two main kinds that have studied recent years. Their bioactive components found to possess variety therapeutic potentials. was improves cognitive functions mild impairments patients living at high altitude protects them neurodegenerative damage through antioxidant properties. possesses artepillin C (ARC) key component, anticancer potential. contains caffeic acid phenethyl ester (CAPE) with multiple Our lab performed vitro vivo assays extracts prepared active ingredients. We provided experimental evidence these anticancer, antistress hypoxia-modulating activities. Furthermore, conjugation γCD proved be more effective. In present review, we portray showing potential candidate drug ailments improve life.

Language: Английский

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