In vitro and in silico pharmaco-nutritional assessments of some lesser-known Nigerian nuts: Persea americana, Tetracarpidium conophorum, and Terminalia catappa DOI Creative Commons

E. Eyong,

Iwara Arikpo Iwara, Eyuwa Ignatius Agwupuye

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0319756 - e0319756

Published: April 9, 2025

Together with their nutritional qualities, the biosafety, antidiabetic, antioxidant, and anti-inflammatory effects of Tetracarpidium conophorum nuts, Persea americana seeds, Terminalia cattapa kernels were evaluated in vitro silico. RBC membrane stabilisation for characteristics, antioxidant activities by ABTS, DPPH, H2O2, nitric oxide scavenging assays, α-glucosidase α-amylase inhibitory assays conducted used to evaluate anti-diabetic activity. With an IC50 value 208 μg/mL , P. showed maximum amount inhibition, according results, while T. catappa a somewhat lower degree inhibition at 236 . exhibited highest 312 µg/mL. strongest DPPH radical activity, ABTS effectiveness neutralising hydrogen peroxide. In tests using human red blood cells, hemolysis. While higher concentrations copper, manganese, potassium, calcium, magnesium concentrations. had considerably levels ash, proteins, lipids, carbohydrates than which quantity crude fibre, proximate analysis. Molecular docking experiments have revealed that plant extracts from americana, substantial binding affinities towards amylase. Pseudococaine, M-(1-methylbutyl) phenylmethylcarbamate, o-xylene, 1-deoxynojirimycin four compounds those acarbose. Acarbose nitrate not as compatible scores compared dimethyl phthalate, pseudococaine, M-(1-Methylbutyl)phenyl methylcarbamate, 2-chloro-3-oxohexanedioic acid, methyl 2-chloro-5-nitrobenzoate. These results suggest these hold great potential creation therapeutic medications specifically target oxidative stress-related diseases like diabetes.

Language: Английский

Antitumor Mechanisms of Lycium barbarum Fruit: An Overview of In Vitro and In Vivo Potential DOI Creative Commons
Maria Rosaria Miranda, Vincenzo Vestuto, Giuseppina Amodio

et al.

Life, Journal Year: 2024, Volume and Issue: 14(3), P. 420 - 420

Published: March 21, 2024

Lycium barbarum, known as goji berry or wolfberry, is a fruit long associated with health benefits, showing plethora of effects ranging from antioxidant, anticancer, anti-inflammatory, and immunomodulatory effects. Its potential attributed to the significant presence polysaccharides, glycopeptides, polyphenols, flavonoids, carotenoids, their derivatives. These compounds effectively counteract action free radicals, positively influencing cellular balance intracellular signaling, contributing overall cell function acting on multiple molecular pathways. Several fractions extracted berries demonstrate antitumor properties, particularly effective against breast cancer, without cytotoxic normal human cells. Hence, review explored fundamental traits bioactive elements in barbarum cancer treatment and, specifically, cancer. It focused elucidating wolfberry’s influenced biochemical pathways, its synergism anticancer drugs, alleviate side existing treatments.

Language: Английский

Citations

14
Exploring the Ancient Wisdom and Modern Relevance of Chinese Medicine: A Comprehensive Review DOI Creative Commons
Kuldeep Singh, Jeetendra Kumar Gupta, Divya Jain

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 11, P. 100448 - 100448

Published: May 21, 2024

Chinese medicine, rooted in a rich history dating back thousands of years, offers holistic approach to healthcare that has endured the test time. This comprehensive review explores ancient wisdom and modern relevance shedding light on its principles, practices, adaptability contemporary healthcare. employs multidisciplinary approach, drawing upon texts, scientific research, clinical studies elucidate core tenets medicine. A literature search was conducted various databases, including PubMed, Web Science, traditional medical identify relevant articles, books, historical documents. The synthesizes fundamental concepts such as Qi, Yin-Yang, five elements, meridian system, while examining their physiological significance context It also delves into integration Medicine mainstream systems worldwide, highlighting growing acceptance utilization treatment conditions, chronic pain, mental health disorders, complementary cancer care. discussion section synergy between medicine emphasizing potential for bridges gap Eastern Western addresses challenges opportunities integrating evidence-based importance rigorous research standardization. In conclusion, this underscores enduring showcasing landscape. advocates continued collaboration conventional systems, fostering more patient-centered By embracing alongside advancements, we can pave way healthier balanced future.

Language: Английский

Citations

9
Patients’ trust in the Indian healthcare system and its impact on the intention to use artificial intelligence-based healthcare chatbots DOI

Aarthy Chellasamy,

N. Elangovan,

Aishwarya Nagarathinam

et al.

Journal of Asia Business Studies, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Purpose Indian patients have different medicine systems available at the service that alter their healthseeking behaviour (HSB). This study aims to examine beliefs and of in India towards healthcare system how it affects intention use chatbots. Design/methodology/approach A survey instrument was developed from standard scales validated by experts. The data collected 397 respondents an urban area tested using a structural equation model SAS JMP software. Findings found awareness perception chatbots distrust on doctors health impact trust chatbot. results show influences belief alternative HSB also influence findings imply health-care should cater medicine. Research limitations/implications conducted only among population because services based technology are more metro cities. Bengaluru is considered representative India. Practical implications level disruption can provide makes this significant. will help manage factors enable chatbot inclusivity, as current inaccessible many patients. Originality/value paper addresses identified need patients’ disruptions these cause undeniable eventually transform sector.

Language: Английский

Citations

1
Botanical scenario, phytochemical insights and therapeutic applications of Luffa acutangula in traditional herbal practices DOI

Shahzadi Bano,

Jamal Akhtar Ansari, Farogh Ahsan

et al.

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: Feb. 12, 2025

Luffa acutangula (L. acutangula), commonly known as sponge gourd or ridge gourd, is a perennial plant found in various regions worldwide and has importance traditional Indian medicine because of its wide-ranging pharmacological properties. This review examines the phytochemical composition L. therapeutic potential. Phytochemical analysis identified numerous bioactive compounds, including terpenoids, phenolic acids, flavonoids, alkaloids, responsible for diverse activities. The offers comprehensive overview acutangula, detailing phytochemistry effects, which enhance our understanding applications inspire further research natural medicine. However, additional required to elucidate mechanisms involved, refine dosage schedules, explore potential synergistic interactions with standard treatments. findings presented here underscore phytoconstituent this plant, highlighting need ongoing development field

Language: Английский

Citations

1
Nanoparticles of Natural Product-derived Medicines: Beyond the Pandemic DOI Creative Commons
Yedi Herdiana

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42739 - e42739

Published: Feb. 1, 2025

This review explores the synergistic potential of natural products and nanotechnology for viral infections, highlighting key antiviral, immunomodulatory, antioxidant properties to combat pandemics caused by highly infectious viruses. These often result in severe public health crises, particularly affecting vulnerable populations due respiratory complications increased mortality rates. A cytokine storm is initiated when an overload pro-inflammatory cytokines chemokines released, leading a systemic inflammatory response. Viral mutations limited availability effective drugs, vaccines, therapies contribute continuous transmission virus. The coronavirus disease-19 (COVID-19) pandemic has sparked renewed interest product-derived antivirals. efficacy traditional medicines against infections examined. Their anti-inflammatory, are highlighted. discusses how enhances herbal combating infections.

Language: Английский

Citations

1
Modulation of cholesterol metabolism with Phytoremedies in Alzheimer’s disease: A comprehensive review DOI
Sushruta Koppula, Nitu L. Wankhede, Shivkumar S. Sammeta

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102389 - 102389

Published: June 19, 2024

Language: Английский

Citations

5
Selected potential pharmaceutical and medical benefits of phenolic compounds: Recent advances DOI Open Access

M. Abd Elgadir,

Sridevi Chigurupati, Abdalbasit Adam Mariod

et al.

Functional Food Science - Online ISSN 2767-3146, Journal Year: 2023, Volume and Issue: 3(7), P. 108 - 108

Published: July 14, 2023

Objective: Phenolic compounds are essential for defense reactions, including antioxidant, anti-inflammatory, antidiabetic, anti-proliferative activity, and anti-aging activity. Coming from the class of phytomedicine, they widespread in plant kingdom commonly taken as substances daily diet. They mainly found various types edible plants, especially fruits, vegetables, tea. have been investigated their effects on human health due to beneficial against oxidative stress activities. The proposed main mechanism this protective effect harmful oxidation processes is related radical scavenging activity phenolic reactive oxygen nitrogen substances. review uses up-to-date data via manual screening titles abstracts retrieved articles using string pharmaceutical medical benefits keywords obtain publications electronic databases PubMed Google Scholar publish or perish tool. However, priority has given scientific papers, reports, literature issued within past 5 years.Several research conducted potential pharmacological Dietary intake also associated with reducing risk cardiovascular disease, caused by behavioral factors such alcohol abuse, tobacco use, a high-fat diet, sedentary lifestyle. effective fighting diseases.Conclusion: This article highlights currently available information knowledge compounds.Keywords: compounds, flavanoids, Heart Antioxidant, Cancer, Diabetes mellitus

Language: Английский

Citations

11
Unleashing Nature’s potential: a computational approach to discovering novel VEGFR-2 inhibitors from African natural compound using virtual screening, ADMET analysis, molecular dynamics, and MMPBSA calculations DOI Creative Commons
Soukayna Baammi, Achraf El Allali,

Rachid Daoud

et al.

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 20, 2023

One of the characteristic features cancer is angiogenesis, process by which new, aberrant blood vessels are formed from pre-existing vessels. The angiogenesis begins when VEGF binds to its receptor, receptor (VEGFR). formation new provides nutrients that can promote growth cells. When it comes vessel formation, VEGFR2 a critical player. Therefore, inhibiting an effective way target in treatment. aim our research was find VEGFR-2 inhibitors performing virtual screening 13313 African natural compounds using different silico techniques. Using molecular docking calculations and ADMET properties, we identified four exhibited binding affinity ranging -11.0 kcal/mol -11.5 Kcal/mol bound VEGFR-2. These were further analyzed with 100 ns simulations determine their stability energy MM-PBSA method. After comparing Regorafenib, drug approved for anti-angiogenesis treatment, found all candidates (EANPDB 252, NANPDB 4577, 4580), exception EANPDB 76, could similarly effectively Regorafenib. recommend three these agents treatment because they likely deactivate thus inhibit angiogenesis. However, should be noted safety suitability clinical use needs investigation, as computer-assisted study did not include vitro or vivo experiments.

Language: Английский

Citations

11
Plant-Based Functional Foods from Borneo DOI Open Access
Oliver D. John, Noumie Surugau, Jibrail Kansedo

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 200 - 200

Published: Jan. 7, 2025

Borneo, the third-largest island in world, is shared between Malaysia (Sabah and Sarawak), Indonesia (Kalimantan) Brunei. As a biodiversity hotspot, it home to about 15,000 flowering plants 3000 tree species, of which many are endemic region. Locally derived plant-based foods gaining popularity due their lower environmental impact, contribution food sustainability health benefits. The local fruits vegetables Borneo have been used traditionally by indigenous community for medicinal purposes. This knowledge can provide valuable guide potential use as functional foods. review explores contemporary from including fruit, vegetables, seaweeds plant-derived products that locally consumed. findings show unique tropical groups wide diversity phytochemical compositions possess array biological activities anti-inflammatory, antioxidant, anti-microbial, anti-proliferative, anti-fungal, wound healing expectorant properties. range deserves further development wider applications

Language: Английский

Citations

0
Annotated corpus for traditional formula-disease relationships in biomedical articles DOI Creative Commons

Sang-Jun Yea,

Ho Seong Jang, So Young Kim

et al.

Scientific Data, Journal Year: 2025, Volume and Issue: 12(1)

Published: Jan. 7, 2025

The Traditional Formula (TF), a combination of herbs prepared in accordance with traditional medicine principles, is increasingly garnering global attention as an alternative to modern medicine. Specifically, there growing interest exploring TF's therapeutic effects across various diseases. A significant portion the state-of-the-art knowledge regarding relationship between TF and disease found scientific publications, where manual extraction impractical. Thus, Natural Language Processing (NLP) being employed efficiently accurately search extract crucial from unstructured literatures. However, absence high-quality manually annotated corpus focusing on TF-disease relationships hampers use NLP fields biomedical science. This article introduces Formula-Disease Relationship (TFDR) corpus, designed facilitate automatic TFDR includes information gleaned 740 PubMed abstracts, encompassing total 6,211 mentions, 7,166 1,109 them encapsulated within 744 key-sentences.

Language: Английский

Citations

0