Medicinal properties of mangosteen ( Garcinia mangostana L.): A comprehensive update

Food and Chemical Toxicology, Journal Year: 2017, Volume and Issue: 109, P. 102 - 122

Published: Aug. 24, 2017

Language: Английский

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Therapies for Prevention and Treatment of Alzheimer’s Disease

BioMed Research International, Journal Year: 2016, Volume and Issue: 2016, P. 1 - 17

Published: Jan. 1, 2016

Alzheimer’s disease (AD) is the most common cause of dementia associated with a progressive neurodegenerative disorder, prevalence 44 million people throughout world in 2015, and this figure estimated to double by 2050. This characterized blood-brain barrier disruption, oxidative stress, mitochondrial impairment, neuroinflammation, hypometabolism; it related amyloid- β peptide accumulation tau hyperphosphorylation as well decrease acetylcholine levels reduction cerebral blood flow. Obesity major risk factor for AD, because induces adipokine dysregulation, which consists release proinflammatory adipokines decreased anti-inflammatory adipokines, among other processes. The pharmacological treatments AD can be divided into two categories: symptomatic such acetylcholinesterase inhibitors N-methyl-D-aspartate (NMDA) receptor antagonists etiology-based secretase inhibitors, amyloid binders, therapies. Strategies prevention through nonpharmacological are lifestyle interventions exercise, mental challenges, socialization caloric restriction healthy diet. an important health issue on all should informed so that strategies minimize its development may implemented.

Language: Английский

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Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer

Journal for ImmunoTherapy of Cancer, Journal Year: 2021, Volume and Issue: 9(1), P. e001341 - e001341

Published: Jan. 1, 2021

Macrophages are the most important phagocytes in vivo. However, tumor microenvironment can affect function and polarization of macrophages form tumor-associated (TAMs). Usually, abundance TAMs tumors is closely associated with poor prognosis. Preclinical studies have identified pathways regulating infiltration during progression. Furthermore, potential therapeutic strategies targeting been studied, including inhibition macrophage recruitment to tumors, functional repolarization toward an antitumor phenotype, other that elicit macrophage-mediated extracellular phagocytosis intracellular destruction cancer cells. Therefore, increasing impact immunotherapy, new target now being discussed.

Language: Английский

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SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats

Toxicology and Applied Pharmacology, Journal Year: 2017, Volume and Issue: 333, P. 43 - 50

Published: Aug. 12, 2017

Language: Английский

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Role of oxidative stress and antioxidants in daily nutrition and human health

Nutrition, Journal Year: 2016, Volume and Issue: 33, P. 311 - 321

Published: Aug. 8, 2016

Language: Английский

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Insulin and Insulin Resistance in Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(18), P. 9987 - 9987

Published: Sept. 15, 2021

Insulin plays a range of roles as an anabolic hormone in peripheral tissues. It regulates glucose metabolism, stimulates transport into cells and suppresses hepatic production. influences cell growth, differentiation protein synthesis, inhibits catabolic processes such glycolysis, lipolysis proteolysis. insulin-like growth factor-1 receptors are expressed on all types the central nervous system. Widespread distribution brain confirms that insulin signaling important diverse this organ. is known to regulate support cognition, enhance outgrowth neurons, modulate release uptake catecholamine, expression localization gamma-aminobutyric acid (GABA). also able freely cross blood–brain barrier from circulation. In addition, changes signaling, caused inter alia resistance, may accelerate aging, affect plasticity possibly neurodegeneration. There two significant signal transduction pathways: PBK/AKT pathway which responsible for metabolic effects, MAPK survival gene expression. The aim study describe role played by CNS, both healthy people those with pathologies resistance Alzheimer’s disease.

Language: Английский

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Anti-Oxidant and Anti-Inflammatory Activity of Ketogenic Diet: New Perspectives for Neuroprotection in Alzheimer’s Disease

Antioxidants, Journal Year: 2018, Volume and Issue: 7(5), P. 63 - 63

Published: April 28, 2018

The ketogenic diet, originally developed for the treatment of epilepsy in non-responder children, is spreading to be used many diseases, including Alzheimer’s disease. main activity diet has been related improved mitochondrial function and decreased oxidative stress. B-Hydroxybutyrate, most studied ketone body, shown reduce production reactive oxygen species (ROS), improving respiration: it stimulates cellular endogenous antioxidant system with activation nuclear factor erythroid-derived 2-related 2 (Nrf2), modulates ratio between oxidized reduced forms nicotinamide adenine dinucleotide (NAD+/NADH) increases efficiency electron transport chain through expression uncoupling proteins. Furthermore, performs anti-inflammatory by inhibiting kappa-light-chain-enhancer activated B cells (NF-kB) nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome as well histone deacetylases (HDACs), memory encoding. underlying mechanisms perspectives disease are discussed.

Language: Английский

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Obesity-associated NLRC4 inflammasome activation drives breast cancer progression

Nature Communications, Journal Year: 2016, Volume and Issue: 7(1)

Published: Oct. 6, 2016

Abstract Obesity is associated with an increased risk of developing breast cancer and also worse clinical prognosis. The mechanistic link between obesity progression remains unclear, there has been no development specific treatments to improve the outcome obese patients. Here we show that obesity-associated NLRC4 inflammasome activation/ interleukin (IL)-1 signalling promotes progression. tumour microenvironment in context induces increase tumour-infiltrating myeloid cells activated turn activates IL-1β, which drives disease through adipocyte-mediated vascular endothelial growth factor A (VEGFA) expression angiogenesis. Further studies treatment mice metformin inhibits a marked decrease This report provides causal mechanism by lays out foundation block activation or IL-1β transduction may be useful for

Language: Английский

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Insulin Resistance and Oxidative Stress in the Brain: What’s New?

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(4), P. 874 - 874

Published: Feb. 18, 2019

The latest studies have indicated a strong relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, mild cognitive impairment. Although some these abnormalities could be explained by chronic hyperglycaemia, hyperinsulinemia, dyslipidaemia, and/or prolonged whole-body inflammation, the key role is attributed to neuronal redox imbalance oxidative damage. In this mini review, we provide schematic overview intracellular stress mitochondrial in IR brain. We highlight important correlations found so far brain stress, ceramide generation, β-amyloid accumulation, as well apoptosis conditions.

Language: Английский

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Insulin signaling pathway and related molecules: Role in neurodegeneration and Alzheimer's disease

Neurochemistry International, Journal Year: 2020, Volume and Issue: 135, P. 104707 - 104707

Published: Feb. 21, 2020

Language: Английский

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