Nutritional Composition and Bioactive Compounds in Tomatoes and Their Impact on Human Health and Disease: A Review

Foods, Journal Year: 2020, Volume and Issue: 10(1), P. 45 - 45

Published: Dec. 26, 2020

Tomatoes are consumed worldwide as fresh vegetables because of their high contents essential nutrients and antioxidant-rich phytochemicals. contain minerals, vitamins, proteins, amino acids (leucine, threonine, valine, histidine, lysine, arginine), monounsaturated fatty (linoleic linolenic acids), carotenoids (lycopene β-carotenoids) phytosterols (β-sitosterol, campesterol stigmasterol). Lycopene is the main dietary carotenoid in tomato tomato-based food products lycopene consumption by humans has been reported to protect against cancer, cardiovascular diseases, cognitive function osteoporosis. Among phenolic compounds present tomato, quercetin, kaempferol, naringenin, caffeic acid lutein most common. Many these have antioxidant activities effective protecting human body various oxidative stress-related diseases. Dietary tomatoes increase body's level antioxidants, trapping reactive oxygen species reducing damage important biomolecules such membrane lipids, enzymatic proteins DNA, thereby ameliorating stress. We reviewed nutritional phytochemical compositions tomatoes. In addition, impacts constituents on health, particularly some degenerative also discussed.

Language: Английский

---

CVD and Oxidative Stress

Journal of Clinical Medicine, Journal Year: 2017, Volume and Issue: 6(2), P. 22 - 22

Published: Feb. 20, 2017

Nowadays, it is known that oxidative stress plays at least two roles within the cell, generation of cellular damage and involvement in several signaling pathways its balanced normal state. So far, a substantial amount time effort has been expended search for clear link between cardiovascular disease (CVD) effects stress. Here, we present an overview different sources types reactive oxygen species CVD, highlight relationship CVD discuss most prominent molecules play important role pathophysiology. Details are given regarding common pharmacological treatments used distress how some them acting upon ROS-related molecules. Novel therapies, recently proposed ROS biomarkers, as well future challenges field addressed. It apparent better understanding contributing to pathophysiology far from over, new approaches more suitable biomarkers needed latter be accomplished.

Language: Английский

---

Advances in nanoparticle and microparticle delivery systems for increasing the dispersibility, stability, and bioactivity of phytochemicals

Biotechnology Advances, Journal Year: 2018, Volume and Issue: 38, P. 107287 - 107287

Published: Aug. 4, 2018

Language: Английский

---

Oxidative Stress in Autism Spectrum Disorder

Molecular Neurobiology, Journal Year: 2020, Volume and Issue: 57(5), P. 2314 - 2332

Published: Feb. 5, 2020

Language: Английский

---

Reductive Stress in Inflammation-Associated Diseases and the Pro-Oxidant Effect of Antioxidant Agents

International Journal of Molecular Sciences, Journal Year: 2017, Volume and Issue: 18(10), P. 2098 - 2098

Published: Oct. 5, 2017

Abstract: Reductive stress (RS) is the counterpart oxidative (OS), and can occur in response to conditions that shift redox balance of important biological couples, such as NAD+/NADH, NADP+/NADPH, GSH/GSSG, a more reducing state. Overexpression antioxidant enzymatic systems leads excess equivalents deplete reactive species, driving cells RS. A feedback regulation established which chronic RS induces OS, turn, stimulates again Excess may regulate cellular signaling pathways, modify transcriptional activity, induce alterations formation disulfide bonds proteins, reduce mitochondrial function, decrease metabolism, thus, contribute development some diseases NF-κB, redox-sensitive transcription factor, participates. Here, we described an inflammatory condition associated RS, where delayed folding, disordered transport, failed oxidation, aggregation are found. Some these protein cardiomyopathy, hypertrophic muscular dystrophy, pulmonary hypertension, rheumatoid arthritis, Alzheimer’s disease, metabolic syndrome, among others. Moreover, consumption supplements, vitamins and/or flavonoids, have pro-oxidant effects alter equilibrium even diminishing life expectancy.

Language: Английский

---

The Effect of Lutein on Eye and Extra-Eye Health

Nutrients, Journal Year: 2018, Volume and Issue: 10(9), P. 1321 - 1321

Published: Sept. 18, 2018

Lutein is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. In particular, known to improve or even prevent age-related macular disease which the leading cause blindness and vision impairment. Furthermore, many studies have may also positive effects in different clinical conditions, thus ameliorating cognitive function, decreasing risk cancer, improving measures cardiovascular At present, available data been obtained from both observational investigating intake food, few intervention trials assessing efficacy supplementation. general, sustained consumption, either through diet supplementation, contribute reducing burden chronic diseases. However, there are conflicting concerning inducing favorable human health no univocal most appropriate dosage for daily Therefore, based recent findings, this review will focus properties, dietary sources, usual intake, health, toxicity.

Language: Английский

---

The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in Obesity

Oxidative Medicine and Cellular Longevity, Journal Year: 2017, Volume and Issue: 2017(1)

Published: Jan. 1, 2017

Over the past two decades, obesity has been one of major public health concerns in most countries. In search for new molecules that could be used treatment obesity, good perspectives have opened up polyphenols, a class natural bioactive phytochemicals. Experimental and limited clinical trial evidence supports some polyphenols such as quercetin, curcumin, resveratrol potential benefit functions on treatment. This brief review focuses main above‐named adipose tissue. These may play beneficial effects tissue under obese condition by alleviating intracellular oxidative stress, reducing chronic low‐grade inflammation, inhibiting adipogenesis lipogenesis, suppressing differentiation preadipocytes to mature adipocytes.

Language: Английский

---

Aging - Oxidative stress, antioxidants and computational modeling

Heliyon, Journal Year: 2020, Volume and Issue: 6(5), P. e04107 - e04107

Published: May 1, 2020

Aging is a degenerative, biological, time-dependent, universally conserved process thus designed as one of the highest known risk factors for morbidity and mortality. Every individual has its own aging mechanisms both environmental conditions (75%) genetics (25%) account aging. Several theories have been proposed until now but not even single theory solves this mystery. There are still some queries un-answered to scientific community regarding behind However, oxidative stress (OST) considered famous that sees mitochondria leading organelles which largely contribute process. Many reactive oxygen species (ROS) produced endogenously exogenously associated with But mitochondrial ROS dysfunction due contributors toward Although damage cell machinery, new evidence suggests their role in signal transduction regulate biological physiological processes. Moreover, besides mitochondria, other important such peroxisome endoplasmic reticulum also produce nature provided humans free radical scavengers called antioxidants protect from harmful effects ROS. Future predictions aging, biochemical involved, biomarkers internal external can be easily done machine learning algorithms computational models. This review explains aspects contribution producing importance fighting against ROS, different models developed understand complexities

Language: Английский

---

Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke

Antioxidants, Journal Year: 2021, Volume and Issue: 10(12), P. 1886 - 1886

Published: Nov. 25, 2021

The production of free radicals is inevitably associated with metabolism and other enzymatic processes. Under physiological conditions, however, are effectively eliminated by numerous antioxidant mechanisms. Oxidative stress occurs due to an imbalance between the elimination under pathological conditions. also ageing. brain prone oxidative damage because its high metabolic activity vulnerability ischemic damage. stress, thus, plays a major role in pathophysiology both acute chronic pathologies brain, such as stroke, traumatic injury or neurodegenerative diseases. goal this article summarize basic concepts significance pathologies, well discuss treatment strategies for dealing stroke.

Language: Английский

---

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: March 10, 2022

Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA its derivatives have been used for many centuries due to their natural healing medicinal properties. possesses various biological pharmacological activities, including antioxidant, anti-inflammatory, anticancer, neuroprotective effects. The potential therapeutic effects of are mediated via repression inhibition transcription growth factors. anticancer human cell cultures animal models. However, the biomolecular interactions pathways described highlighting target binding proteins signaling molecules. current review focuses on CA’s chemical, physical, properties, We further characteristics future directions.

Language: Английский

---