PubMed,
Journal Year:
2023,
Volume and Issue:
26(8), P. 853 - 871
Published: Jan. 1, 2023
Cardiovascular
diseases
(CVDs)
are
some
of
the
major
causes
death
worldwide.
The
modern
lifestyle
elevates
risk
CVDs.
CVDs
have
several
factors
such
as
obesity,
dyslipidemia,
atherosclerosis,
hypertension,
and
diabetes.
Using
herbal
natural
products
plays
a
pivotal
role
in
treatment
different
CVDs,
diabetes,
metabolic
syndrome.
Propolis,
resinous
mixture,
is
made
by
honey
bees.
Its
main
components
phenolics
terpenoid
compounds
caffeic
acid
phenethyl
ester,
chrysin,
quercetin.
In
this
review,
multiple
studies
regarding
pharmacological
impacts
propolis
its
constituents
with
their
related
mechanisms
action
against
mentioned
CVD
been
discussed
detail.
Here,
we
used
electronic
databases
or
search
engines
Scopus,
Web
Science,
Pubmed,
Google
Scholar
without
time
limitations.
primary
chrysin
Propolis
found
to
exhibit
anti-obesity,
anti-hypertension,
anti-dyslipidemic,
anti-atherosclerosis,
anti-diabetic
effects.
vast
majority
review
demonstrate
that
could
therapeutic
effects
via
antioxidant,
anti-inflammatory,
reducing
adipogenesis,
HMG-CoA
reductase
inhibitory
effect,
inhibition
ACE,
increasing
insulin
secretion,
NO
level,
etc.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2018,
Volume and Issue:
2018(1)
Published: Jan. 1, 2018
Honeybees
products
comprise
of
numerous
substances,
including
propolis,
bee
pollen,
and
royal
jelly,
which
have
long
been
known
for
their
medicinal
health‐promoting
properties.
Their
wide
biological
effects
used
since
antiquity.
Bee
are
considered
to
be
a
potential
source
natural
antioxidants
such
as
flavonoids,
phenolic
acids,
or
terpenoids.
Nowadays,
the
still
growing
concern
in
substances
capable
counteracting
oxidative
stress
underlying
pathogenesis
diseases,
neurodegenerative
disorders,
cancer,
diabetes,
atherosclerosis,
well
negative
different
harmful
factors
drugs,
is
being
observed.
Having
regarded
importance
acquiring
drugs
from
sources,
this
review
aimed
at
updating
current
state
knowledge
antioxidant
capacity
selected
products,
namely,
antioxidant‐related
therapeutic
applications.
Moreover,
particular
attention
has
attributed
understanding
mechanisms
properties
products.
The
influence
species,
plant
origin,
geographic
location,
seasonality
type
extraction
solutions
on
composition
extracts
were
also
discussed.
Biomedicine & Pharmacotherapy,
Journal Year:
2020,
Volume and Issue:
131, P. 110622 - 110622
Published: Aug. 17, 2020
Propolis,
a
resinous
material
produced
by
honey
bees
from
plant
exudates,
has
long
been
used
in
traditional
herbal
medicine
and
is
widely
consumed
as
health
aid
immune
system
booster.
The
COVID-19
pandemic
renewed
interest
propolis
products
worldwide;
fortunately,
various
aspects
of
the
SARS-CoV-2
infection
mechanism
are
potential
targets
for
compounds.
entry
into
host
cells
characterized
viral
spike
protein
interaction
with
cellular
angiotensin-converting
enzyme
2
(ACE2)
serine
protease
TMPRSS2.
This
involves
PAK1
overexpression,
which
kinase
that
mediates
coronavirus-induced
lung
inflammation,
fibrosis,
suppression.
Propolis
components
have
inhibitory
effects
on
ACE2,
TMPRSS2
signaling
pathways;
addition,
antiviral
activity
proven
vitro
vivo.
In
pre-clinical
studies,
promoted
immunoregulation
pro-inflammatory
cytokines,
including
reduction
IL-6,
IL-1
beta
TNF-α.
monocytes
macrophages,
well
Jak2/STAT3,
NF-kB,
inflammasome
pathways,
reducing
risk
cytokine
storm
syndrome,
major
mortality
factor
advanced
disease.
also
shown
promise
an
treatment
comorbidities
particularly
dangerous
patients,
respiratory
diseases,
hypertension,
diabetes,
cancer.
Standardized
consistent
bioactive
properties
now
available.
Given
current
emergency
caused
limited
therapeutic
options,
presented
promising
relevant
option
safe,
easy
to
administrate
orally
readily
available
natural
supplement
functional
food.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1519 - 1519
Published: Feb. 11, 2025
Propolis
(bee
glue)
is
a
complex
mixture
of
resins,
waxes,
and
gums,
it
resinous
exudate
manufactured
by
honey
bees
to
maintain
the
integrity
hive
defend
against
external
threats.
This
multifunctional
material
exhibits
several
striking
properties.
The
anti-inflammatory
properties
propolis
have
made
subject
traditional
medicine
over
time,
from
ancient
Egyptian
mummification
modern
complementary
medicine.
with
rich
phytochemicals,
such
as
polyphenols
flavonoids,
exhibit
anti-inflammatory,
antioxidant,
anticancer
effects.
review
describes
multiple
uses
propolis,
highlighting
role
an
exceptional
natural
resource
high
therapeutic
potential.
Scientific Reports,
Journal Year:
2019,
Volume and Issue:
9(1)
Published: May 13, 2019
Abstract
Propolis
is
a
natural
product
with
many
biological
properties
including
hypoglycemic
activity
and
modulating
lipid
profile.
The
present
study
was
designed
to
evaluate
the
effect
of
Iranian
propolis
extract
on
glucose
metabolism,
Lipid
profile,
Insulin
resistance,
renal
liver
function
as
well
inflammatory
biomarkers
in
patients
type
2
diabetes
mellitus
(T2DM).
A
double-blind,
placebo-controlled
clinical
trial
conducted.
duration
lasted
90
days.
Patients
T2DM
were
recruited
randomly
divided
into
an
group
(1000
mg/day)
(n
=
50)
placebo
44).
There
significant
decrease
serum
levels
glycosylated
hemoglobin
(HbA1c),
2-hour
post
prandial
(2hpp),
insulin,
homeostasis
model
assessment-insulin
resistance
(HOMA-IR),
assessment
β-cell
(HOMA-β),
High
sensitive
C-reactive
protein
(hs-CRP),
tumor
necrosis
factor-α
(TNF-α).
However,
there
notable
elevation
HDL-C
compared
group.
In
addition,
reduction
transaminase
(ALT
AST)
blood
urea
nitrogen
(BUN)
concentrations
observed.
has
beneficial
effects
reducing
glucose,
insulin
cytokines.
It
also
useful
treatment
for
preventing
dysfunction,
as,
elevating
T2DM.
Journal of Pharmacy and Pharmacology,
Journal Year:
2021,
Volume and Issue:
73(3), P. 281 - 299
Published: Jan. 1, 2021
Abstract
Objectives
Viral
outbreaks
are
a
frequent
concern
for
humans.
A
great
variety
of
drugs
has
been
used
to
treat
viral
diseases,
which
not
always
safe
and
effective
may
induce
adverse
effects,
indicating
the
need
new
antiviral
extracted
from
natural
sources.
Propolis
is
bee-made
product
exhibiting
many
biological
properties.
An
overview
viruses,
immunity,
propolis
safety
its
immunomodulatory
action
reported,
as
well
perspectives
coronavirus
disease
2019
(COVID-19)
treatment.
PubMed
platform
was
data
collection,
searching
keywords
“propolis”,
“virus”,
“antiviral”,
“antimicrobial”
“coronavirus”.
Key
findings
exerts
activity;
however,
clinical
trials
should
investigate
effects
on
individuals
with
in
combination
or
vaccines.
Summary
Regarding
COVID-19,
be
investigated
directly
virus
vitro
infected
alone
drugs,
due
anti-inflammatory
action.
administration
simultaneously
vaccines
analyzed,
adjuvant
properties,
enhance
individuals’
immune
response.
The
search
therapeutic
targets
useful
find
out
how
can
help
control
COVID-19.
Cells,
Journal Year:
2024,
Volume and Issue:
13(5), P. 390 - 390
Published: Feb. 24, 2024
Aging
populations
worldwide
are
placing
age-related
diseases
at
the
forefront
of
research
agenda.
The
therapeutic
potential
natural
substances,
especially
propolis
and
its
components,
has
led
to
these
products
being
promising
agents
for
alleviating
several
cellular
molecular-level
changes
associated
with
diseases.
With
this
in
mind,
scientists
have
introduced
a
contextual
framework
guide
future
aging
research,
called
hallmarks
aging.
This
encompasses
various
mechanisms
including
genomic
instability,
epigenetic
changes,
mitochondrial
dysfunction,
inflammation,
impaired
nutrient
sensing,
altered
intercellular
communication.
Propolis,
rich
array
bioactive
compounds,
functions
as
potent
functional
food,
modulating
metabolism,
gut
microbiota,
immune
response,
offering
significant
health
benefits.
Studies
emphasize
propolis'
properties,
such
antitumor,
cardioprotective,
neuroprotective
effects,
well
ability
mitigate
oxidative
stress,
DNA
damage,
pathogenic
bacteria
growth.
article
underscores
current
scientific
evidence
supporting
role
controlling
molecular
characteristics
linked
hallmarks,
hypothesizing
geroscience
research.
aim
is
discover
novel
strategies
improve
quality
life
older
individuals,
addressing
existing
deficits
perspectives
area.
Diabetes Therapy,
Journal Year:
2017,
Volume and Issue:
9(1), P. 101 - 111
Published: Dec. 6, 2017
Propolis
is
a
natural
product
with
many
biological
activities.
The
present
study
was
designed
to
evaluate
the
effects
of
Chinese
propolis
on
glucose
metabolism,
antioxidant
function,
and
inflammatory
cytokines
in
patients
type
2
diabetes
mellitus
(T2DM).In
18-week
study,
recruited
T2DM
were
randomly
divided
into
group
(900
mg/day)
(n
=
31)
control
30)
according
fasting
serum
levels
at
baseline.At
end
no
significant
difference
found
between
groups
glucose,
glycosylated
hemoglobin,
insulin,
aldose
reductase,
or
adiponectin.
However,
GSH,
flavonoids,
polyphenols
significantly
increased,
lactate
dehydrogenase
activity
reduced
group.
Meanwhile,
IL-6
increased
group.Chinese
effective
improving
function
patients,
partly
by
increasing
parameters.
