Biomarkers, oxidative stress and autophagy in skin aging

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 59, P. 101036 - 101036

Published: Feb. 24, 2020

Language: Английский

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A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy

Nutrients, Journal Year: 2019, Volume and Issue: 11(2), P. 474 - 474

Published: Feb. 23, 2019

Tea is one of the most widely consumed beverages worldwide, and available in various forms. Green tea richer antioxidants compared to other forms tea. composed polyphenols, caffeine, minerals, trace amounts vitamins, amino acids, carbohydrates. The composition varies depending on fermentation process employed produce it. phytochemicals present green are known stimulate central nervous system maintain overall health humans. Skin aging a complex mediated by intrinsic factors such as senescence, along with extrinsic damage induced external chronic exposure ultraviolet (UV) irradiation—A photoaging—Which can lead erythema, edema, sunburn, hyperplasia, premature aging, development non-melanoma melanoma skin cancers. UV cause either directly, through absorption energy biomolecules, or indirectly, increased production reactive oxygen species (ROS) nitrogen (RNS). potent source exogenous antioxidant candidates that could nullify excess endogenous ROS RNS inside body, thereby diminish impact photoaging. Several vivo vitro studies suggest supplementation increases collagen elastin fiber content, suppresses degrading enzyme MMP-3 skin, conferring an anti-wrinkle effect. precise mechanism behind anti-photoaging effect has not been explored yet. Studies using worm model have suggested lifespan extension depends DAF-16 pathway. Apart from this, reported stress resistance neuroprotective properties. Its scavenging activity makes it mediator, also regulate metal ions. It polyphenols induce expression different enzymes hinder DNA oxidative damage. Growing evidence suggests be used potential agent mediate neurodegenerative diseases, including Alzheimer’s disease. EGCG, abundant catechin tea, was found suppress neurotoxicity Aβ activates glycogen synthase kinase-3β (GSK-3β), inhibiting c-Abl/FE65—the cytoplasmic nonreceptor tyrosine kinase which involved nuclear translocation. Additionally, autophagy, revitalizing organism consuming able activate autophagy HL-60 xenographs increasing PI3 BECLIN-1. This manuscript describes anti-photoaging, resistance, properties functional foods—green

Language: Английский

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Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives

Cosmetics, Journal Year: 2021, Volume and Issue: 8(4), P. 106 - 106

Published: Nov. 10, 2021

In recent years, interest in the health effects of natural antioxidants has increased due to their safety and applicability cosmetic formulation. Nevertheless, efficacy vivo is less documented than prooxidant properties vivo. Plant extracts rich vitamins, flavonoids, phenolic compounds can induce oxidative damage by reacting with various biomolecules while also providing antioxidant properties. Because biological activities differ, effectiveness for slowing aging process remains unclear. This review article focuses on use skincare possible mechanisms underlying desired effect, along applications formulation limitations.

Language: Английский

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Focus on the Contribution of Oxidative Stress in Skin Aging

Antioxidants, Journal Year: 2022, Volume and Issue: 11(6), P. 1121 - 1121

Published: June 6, 2022

Skin aging is one of the most evident signs human aging. Modification skin during life span characterized by fine lines and wrinkling, loss elasticity volume, laxity, rough-textured appearance, pallor. In contrast, photoaged associated with uneven pigmentation (age spot) markedly wrinkled. At cellular molecular level, it consists multiple interconnected processes based on biochemical reactions, genetic programs, occurrence external stimulation. The principal perturbation in driving senescence alteration oxidative balance. chronological aging, reactive oxygen species (ROS) are produced mainly through metabolism adenosine triphosphate (ATP) generation from glucose mitochondrial dysfunction, whereas extrinsic redox equilibrium caused environmental factors, such as ultraviolet radiation, pollution, cigarette smoking, inadequate nutrition. During process, stress attributed to both augmented ROS production reduced levels enzymatic non-enzymatic protectors. Apart appearance structural change, throughout gradually loses its natural functional characteristics regenerative potential. With immune system also undergoes manifested a ability counteract infections frequency autoimmune neoplastic diseases. This review proposes an update role clinical manifestation well mechanisms that underline this phenomenon sometimes accelerated factors.

Language: Английский

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Aging - Oxidative stress, antioxidants and computational modeling

Heliyon, Journal Year: 2020, Volume and Issue: 6(5), P. e04107 - e04107

Published: May 1, 2020

Aging is a degenerative, biological, time-dependent, universally conserved process thus designed as one of the highest known risk factors for morbidity and mortality. Every individual has its own aging mechanisms both environmental conditions (75%) genetics (25%) account aging. Several theories have been proposed until now but not even single theory solves this mystery. There are still some queries un-answered to scientific community regarding behind However, oxidative stress (OST) considered famous that sees mitochondria leading organelles which largely contribute process. Many reactive oxygen species (ROS) produced endogenously exogenously associated with But mitochondrial ROS dysfunction due contributors toward Although damage cell machinery, new evidence suggests their role in signal transduction regulate biological physiological processes. Moreover, besides mitochondria, other important such peroxisome endoplasmic reticulum also produce nature provided humans free radical scavengers called antioxidants protect from harmful effects ROS. Future predictions aging, biochemical involved, biomarkers internal external can be easily done machine learning algorithms computational models. This review explains aspects contribution producing importance fighting against ROS, different models developed understand complexities

Language: Английский

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Natural Compounds and Products from an Anti-Aging Perspective

Molecules, Journal Year: 2022, Volume and Issue: 27(20), P. 7084 - 7084

Published: Oct. 20, 2022

Aging is a very complex process that accompanied by degenerative impairment in many of the major functions human body over time. This inevitable influenced hereditary factors, lifestyle, and environmental influences such as xenobiotic pollution, infectious agents, UV radiation, diet-borne toxins, so on. Many external internal signs symptoms are related with aging senescence, including skin dryness wrinkles, atherosclerosis, diabetes, neurodegenerative disorders, cancer, etc. Oxidative stress, consequence imbalance between pro- antioxidants, one main provoking factors causing aging-related damages concerns, due to generation highly reactive byproducts oxygen nitrogen species during metabolism, which result cellular damage apoptosis. Antioxidants can prevent these processes extend healthy longevity ability inhibit formation free radicals or interrupt their propagation, thereby lowering level oxidative stress. review focuses on supporting antioxidant system organism balancing diet through consumption necessary amount natural ingredients, vitamins, minerals, polyunsaturated fatty acids (PUFA), essential amino acids, probiotics, plants’ fibers, nutritional supplements, polyphenols, some phytoextracts, drinking water.

Language: Английский

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A systematic review of natural products for skin applications: Targeting inflammation, wound healing, and photo-aging

Phytomedicine, Journal Year: 2023, Volume and Issue: 115, P. 154824 - 154824

Published: April 19, 2023

Every day the skin is constantly exposed to several harmful factors that induce oxidative stress. When cells are incapable maintain balance between antioxidant defenses and reactive oxygen species, no longer can keep its integrity homeostasis. Chronic inflammation, premature aging, tissue damage, immunosuppression possible consequences induced by sustained exposure environmental endogenous species. Skin immune non-immune together with microbiome essential efficiently trigger responses For this reason, an ever-increasing demand for novel molecules capable of modulating functions in has risen level their development, particularly field natural product-derived molecules. In review, we explore different classes showed evidence modulate responses, as well target receptors signaling pathways. Moreover, describe role polyphenols, polysaccharides, fatty acids, peptides, probiotics treatments conditions, including wound healing, infection, allergies, aging. Literature was searched, analyzed, collected using databases, PubMed, Science Direct, Google Scholar. The search terms used included "Skin", "wound healing", "natural products", "skin microbiome", "immunomodulation", "anti-inflammatory", "antioxidant", "infection", "UV radiation", "polyphenols", "polysaccharides", "fatty acids", "plant oils", "peptides", "antimicrobial peptides", "probiotics", "atopic dermatitis", "psoriasis", "auto-immunity", "dry skin", "aging", etc., combinations these keywords. Natural products offer solutions conditions. Significant anti-inflammatory activities were reported, followed ability skin. Several membrane-bound recognize diverse types natural-derived molecules, promoting improve Despite increasing progress drug discovery, limiting need future clarification. Understanding safety, biological activities, precise mechanisms action a priority characterization active compounds responsible that. This review provides directions studies development new important pharmaceutical cosmeceutical value.

Language: Английский

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A review on health benefits and processing of tempeh with outlines on its functional microbes

Future Foods, Journal Year: 2024, Volume and Issue: 9, P. 100330 - 100330

Published: March 18, 2024

Tempeh is a nutritious fermented legume food made from soybeans and commonly consumed in Southeast Asia especially Indonesia Malaysia. The fermentation process involves growth of mold, Rhizopus spp. which transforms into white firm cake-like product as enzymes break down complex nutrients simpler forms making the high protein nutrient rich more bioavailable. Soybeans also leads to production metabolites such organic acids, antioxidants antimicrobial compounds increase vitamins content, enhance nutritional value shelf life tempeh. Consumption tempeh has been linked various health advantages including antidiabetic effects, cholesterol-lowering properties, improved cognitive function, antitumor anticancer anti-aging effects gut well reduced risk cardiovascular disease. This paper summarises useful information on includes benefits, nutrition functional microbes isolated. It processing substrates provide avenues novel sustainable development offers an excellent alternative plant-based source.

Language: Английский

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Enzyme-assisted Rosa davurica mitigates UV-induced skin photodamage by modulating apoptosis through Nrf2/ARE and MAPK/NF-κB pathways

Journal of Photochemistry and Photobiology B Biology, Journal Year: 2025, Volume and Issue: 263, P. 113098 - 113098

Published: Jan. 6, 2025

Language: Английский

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Natural anti-aging skincare: role and potential

Biogerontology, Journal Year: 2020, Volume and Issue: 21(3), P. 293 - 310

Published: March 11, 2020

Language: Английский

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