Skin aging from mechanisms to interventions: focusing on dermal aging

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: May 10, 2023

Skin aging is a multifaceted process that involves intrinsic and extrinsic mechanisms lead to various structural physiological changes in the skin. Intrinsic associated with programmed cellular senescence, which are caused by endogenous oxidative stress damage. Extrinsic result of environmental factors, such as ultraviolet (UV) radiation pollution, leads production reactive oxygen species, ultimately causing DNA damage dysfunction. In aged skin, senescent cells accumulate contribute degradation extracellular matrix, further contributes process. To combat symptoms aging, topical agents clinical procedures chemical peels, injectables, energy-based devices have been developed. These address different but devise an effective anti-aging treatment protocol, it essential thoroughly understand skin aging. This review provides overview their significance development treatments.

Language: Английский

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Designing Nutrition for Health—Incorporating Dietary By-Products into Poultry Feeds to Create Functional Foods with Insights into Health Benefits, Risks, Bioactive Compounds, Food Component Functionality and Safety Regulations

Foods, Journal Year: 2023, Volume and Issue: 12(21), P. 4001 - 4001

Published: Nov. 1, 2023

This review delves into the concept of nutrition by design, exploring relationship between poultry production, utilization dietary by-products to create functional foods, and their impact on human health. Functional foods are defined as products that extend beyond basic nutritional value, offering potential benefits in disease prevention management. Various methods, including extraction, fermentation, enrichment, biotechnology, nanotechnology, employed obtain bioactive compounds for these foods. also examines innovative approach enhancing livestock diets through animal-based methods. Bioactive found such essential fatty acids, antioxidants, carotenoids, minerals, vitamins, peptides, highlighted promoting well-being mitigating chronic diseases. Additionally, explores functionality food components within products, emphasizing critical roles bioaccessibility, bioactivity, bioavailability The importance considering key aspects design enhanced production is thoroughly reviewed. safety establishment regulations guidelines was It concluded integration principles empowers individuals make informed choices can prioritize health well-being. By incorporating rich compounds, consumers proactively take steps prevent manage issues, ultimately contributing a healthier society lifestyle.

Language: Английский

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Aging in the dermis: Fibroblast senescence and its significance

Aging Cell, Journal Year: 2023, Volume and Issue: 23(2)

Published: Dec. 1, 2023

Abstract Skin aging is characterized by changes in its structural, cellular, and molecular components both the epidermis dermis. Dermal distinguished reduced dermal thickness, increased wrinkles, a sagging appearance. Due to intrinsic or extrinsic factors, accumulation of excessive reactive oxygen species (ROS) triggers series events, including imbalanced extracellular matrix (ECM) homeostasis, senescent fibroblasts, loss cell identity, chronic inflammation mediated senescence‐associated secretory phenotype (SASP). These events are regulated signaling pathways, such as nuclear factor erythroid 2‐related 2 (Nrf2), mechanistic target rapamycin (mTOR), transforming growth beta (TGF‐β), insulin‐like 1 (IGF‐1). Senescent fibroblasts can induce accelerate age‐related dysfunction other skin cells may even cause systemic inflammation. In this review, we summarize role cutaneous Moreover, underlying mechanisms which influence also discussed.

Language: Английский

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Role of Antioxidants in Skin Aging and the Molecular Mechanism of ROS: A Comprehensive Review

Aspects of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100063 - 100063

Published: Jan. 1, 2025

Language: Английский

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Environmental Air Pollutants Affecting Skin Functions with Systemic Implications

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10502 - 10502

Published: June 22, 2023

The increase in air pollution worldwide represents an environmental risk factor that has global implications for the health of humans worldwide. skin billions people is exposed to a mixture harmful pollutants, which can affect its physiology and are responsible cutaneous damage. Some polycyclic aromatic hydrocarbons photoreactive could be activated by ultraviolet radiation (UVR). Therefore, such UVR exposure would enhance their deleterious effects on skin. Air also affects vitamin D synthesis reducing UVB radiation, essential production D3, tachysterol, lumisterol derivatives. Ambient photopollution, blue-light pollution, cigarette smoke compromise structural integrity, interact with human microbiota, trigger or exacerbate range diseases through various mechanisms. Generally, elicits oxidative stress response activate inflammatory responses. aryl hydrocarbon receptor (AhR) act as sensor small molecules pollutants plays crucial role responses (photo)pollution. On other hand, targeting AhR/Nrf2 emerging novel treatment option induce diseases. AhR downstream regulatory pathways represent signaling system regulating phenotype Yin Yang fashion defined chemical nature activating cellular tissue context.

Language: Английский

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The Skin and Inflamm-Aging

Biology, Journal Year: 2023, Volume and Issue: 12(11), P. 1396 - 1396

Published: Nov. 2, 2023

With its unique anatomical location facing both the external and internal environment, skin has crucial functions, including shielding body from damage caused by ultraviolet radiation chemicals, preventing water loss, acting as a primary barrier against pathogens, participating in metabolic processes like vitamin D production temperature control relaying information to through sensory proprioceptor nerves. Like all organ systems, is known undergo multiple changes with aging. A better understanding of mechanisms that mediate aging-related dysfunction may allow creation targeted therapeutics have beneficial effects not only on aged but also other organs tissues experience loss or decline function The largest can contribute serum inflammatory mediator levels. One alteration occur age an impairment function; since disruption induce inflammation, be major contributor sustained, sub-clinical systemic inflammation associated Such “inflamm-aging” underlie many deleterious observed individuals. This review explores role age-related changes, inflamm-aging.

Language: Английский

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Reactive oxygen species-scavenging nanomaterials for the prevention and treatment of age-related diseases

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 15, 2024

With increasing proportion of the elderly in population, age-related diseases (ARD) lead to a considerable healthcare burden society. Prevention and treatment ARD can decrease negative impact aging disease. The rate is closely associated with production high levels reactive oxygen species (ROS). ROS-mediated oxidative stress triggers aging-related changes through lipid peroxidation, protein oxidation, DNA oxidation. Antioxidants control autoxidation by scavenging free radicals or inhibiting their formation, thereby reducing stress. Benefiting from significant advances nanotechnology, large number nanomaterials ROS-scavenging capabilities have been developed. be divided into two categories: as carriers for delivering drugs, themselves activity. This study summarizes current prevention ARD, highlights potential mechanisms used discusses challenges prospects applications.

Language: Английский

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Enhancement of skin longevity through TGF-β/Smad signaling pathway modulation by Rohu fish (Labeo rohita) collagen peptides in chronologically aged hairless mice

Food Bioscience, Journal Year: 2025, Volume and Issue: 63, P. 105841 - 105841

Published: Jan. 1, 2025

Language: Английский

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Phytochemical analysis and anti-aging efficacy of two Egyptian sweet potato cultivars in a d-galactose-induced skin aging model

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 10, 2025

Abstract Background Sweet potato ( Ipomoea batatas (L.) Lam.) is a member of the family Convolvulaceae. Much research has highlighted its variable biological actions in treatment many disorders. Our study focused on quantitative analysis two Egyptian sweet cultivars (Abees and A195). First, we applied proximate analysis, measured total phenolic, flavonoid contents, performing an HPLC standardization their ethanolic extracts using chlorogenic acid standard. Furthermore, were formulated as topical creams (3% w/w 5% w/w) evaluated for anti-skin aging activity d -galactose-induced skin mouse model. Results revealed that both have high nutritional importance. Abees exhibited higher phenolic contents than A195, while A195 contained concentration acid. Both showed concentration-dependent activity, with cream demonstrating lowest visual skin-aging score, highest catalase (CAT) superoxide dismutase (SOD), malondialdehyde (MDA). Restoration thickness collagen content was observed group, caused noticeable decrease SMAD7 expression. Decreased been correlated to upregulating TGF-β/SMAD3-induced production aged skin. Conclusion This elaborates importance, roots recommend further preclinical clinical investigations potato.

Language: Английский

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Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging

Applied Biological Chemistry, Journal Year: 2025, Volume and Issue: 68(1)

Published: Jan. 16, 2025

Abstract Reactive oxygen species (ROS) produced in the mitochondria of skin cells play a significant role degradation extracellular matrix and induction inflammatory responses, both which are major contributors to aging. Antioxidants that reduce ROS production inhibit lesions considered beneficial for treatment diseases prevention In this study, we evaluated potential Nypa fruticans (NF), is known its antioxidant properties, mitigate tumor necrosis factor-alpha (TNF-α)- interferon-gamma (IFN-γ)-induced damage normal human epidermal keratinocytes. The active constituents identified NF include protocatechuic acid, hydroxybenzoic procyanidin B, catechin, epicatechin. significantly suppressed ROS, nitric oxide (NO), prostaglandin E2 (PGE 2 ), while also reducing levels cytokines interleukin-6 (IL-6) interleukin-1 beta (IL-1β), were elevated by TNF-α/IFN-γ stimulation. Furthermore, restored expression key barrier-related proteins such as serine peptidase inhibitor kazal type 5 (SPINK5), collagen I alpha 1 chain (COLIA1), loricrin (LOR), aquaporin-3 (AQP3), filaggrin (FLG). Additionally, upregulated hyaluronan synthase (HAS) -1 − β-defensin (HBD) -2 3, important hydration innate immune defense. These findings underscore therapeutic applications (NF) mitigating oxidative stress, inflammation, barrier dysfunction, dehydration, microbial imbalances. By targeting multiple pathways implicated aging, represents promising comprehensive approach preserving health addressing age-related dermatological conditions. Moreover, holds not only alleviate manifestations aging but provide basis development innovative therapies. Future investigations should aim further elucidate clinical dermatology maximize benefits.

Language: Английский

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