Drug and Chemical Toxicology,
Journal Year:
2021,
Volume and Issue:
46(1), P. 97 - 103
Published: Dec. 9, 2021
The
aim
of
the
present
study
was
to
evaluate
protective
effect
gallic
acid
(GA)
against
cisplatin
(CDDP)-induced
ovarian
toxicity,
for
first
time.
damage
generated
with
CDDP
(5
mg/kg)
intraperitoneally
(i.p.)
administration
in
rats.
GA
(2.5
and
5
were
administered
i.p.
3
consecutive
days.
carried
out
main
groups
containing
6
rats
each
group:
control,
mg/kg),
CDDP,
+
mg/kg).
levels
malondialdehyde
(MDA),
total
oxidant
status
(TOS),
antioxidant
(TAS),
oxidative
stress
index
(OSI),
catalase
(CAT),
8-hydroxy-2'-deoxyguanosine
(8-OHdG),
caspase-3
tumor
necrosis
factor-alpha
(TNF-α)
determined.
Hematoxylin
eosin
staining
method
employed
histopathological
examination.
In
group,
it
is
determined
that
statistically
significant
decreasing
TAS
CAT,
increasing
MDA,
TOS,
OSI,
8-OHdG,
TNF-α
(p
<
0.05)
compared
control
group.
administrations
significantly
restored
this
0.05).
Although
vascular
congestion,
edema,
hemorrhage,
follicular
degeneration
leukocyte
infiltration
higher
group
than
these
damages
conclusion,
showed
prevented
CDDP-induced
its
antioxidant,
anti-apoptotic
anti-inflammatory
activities.
More
comprehensive
studies
are
needed
see
underlying
mechanisms.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 6, 2024
The
global
prevalence
of
type
2
diabetes
mellitus
(T2DM)
and
Alzheimer’s
disease
(AD)
is
rapidly
increasing,
revealing
a
strong
association
between
these
two
diseases.
Currently,
there
are
no
curative
medication
available
for
the
comorbidity
T2DM
AD.
Ceramides
structural
components
cell
membrane
lipids
act
as
signal
molecules
regulating
homeostasis.
Their
synthesis
degradation
play
crucial
roles
in
maintaining
metabolic
balance
vivo
,
serving
important
mediators
development
neurodegenerative
disorders.
Abnormal
ceramide
metabolism
disrupts
intracellular
signaling,
induces
oxidative
stress,
activates
inflammatory
factors,
impacts
glucose
lipid
homeostasis
metabolism-related
tissues
like
liver,
skeletal
muscle,
adipose
tissue,
driving
occurrence
progression
T2DM.
connection
changes
levels
brain,
amyloid
β
accumulation,
tau
hyper-phosphorylation
evident.
Additionally,
regulates
survival
apoptosis
through
related
signaling
pathways,
actively
participating
Regulatory
enzymes,
their
metabolites,
pathways
impact
core
pathological
molecular
mechanisms
shared
by
AD,
such
insulin
resistance
response.
Consequently,
may
become
potential
therapeutic
target
intervention
paper
comprehensively
summarizes
discusses
role
its
metabolites
pathogenesis
well
latest
progress
treatment
with
Journal of Obstetrics and Gynaecology Research,
Journal Year:
2021,
Volume and Issue:
48(2), P. 411 - 419
Published: Dec. 7, 2021
The
therapeutic
value
of
cisplatin
(CDDP)
as
an
anticancer
drug
is
limited
by
its
ovo-otoxicity.
effect
natural
phenolic
acids
in
the
prevention
many
diseases
related
to
oxidative
stress
has
been
reported.
Here,
ability
p-coumaric
(pCA)
acid,
a
member
acids,
protect
rat
ovary
tissue
against
CDDP-induced
was
investigated.The
study
carried
out
five
main
groups
containing
six
rats
each
group:
control,
pCA
(4
mg/kg),
CDDP,
CDDP
plus
(2
and
mg/kg).
levels
ovarian
malondialdehyde
(MDA),
total
oxidant
status
(TOS),
antioxidant
(TAS),
index
(OSI),
catalase
(CAT),
8-hydroxy-2'-deoxyguanosine
(8-OHdG),
caspase-3,
tumor
necrosis
factor-alpha
(TNF-α)
were
determined.
Hematoxylin
eosin
staining
method
employed
for
histopathological
examination.In
group,
it
determined
that
statistically
significant
decreasing
TAS
CAT,
increasing
MDA,
TOS,
OSI,
8-OHdG,
TNF-α
compared
with
control
group
(p
<
0.05).
administration
significantly
restored
this
damage
dose-dependent
manner
Although
vascular
congestion,
edema,
hemorrhage,
follicular
degeneration,
leukocyte
infiltration
higher
than
administrations
these
damages
0.05).The
data
presented
here
indicate
protects
tissues
stress,
inflammation,
apoptosis.
It
may
be
worthy
consider
usefulness
adjuvant
therapy
cancer
management.
Biomedicine & Pharmacotherapy,
Journal Year:
2021,
Volume and Issue:
135, P. 111246 - 111246
Published: Feb. 1, 2021
Growing
evidence
suggests
that
a
high
fat
diet
(HFD)
induces
oxidative
stress
on
the
central
nervous
system
(CNS),
which
predisposes
to
mood
disorders
and
neuroinflammation.
In
this
study
we
postulated
in
addition
improving
mood,
antidepressant
therapy
would
reverse
inflammatory
changes
brain
of
rats
exposed
HFD.
To
test
our
hypothesis,
measured
effect
agomelatine
(AGO)
anxiety-
depressive-like
behaviors,
as
well
CNS
markers
inflammation
rendered
obese.
Agomelatine
is
an
agonist
melatonin
receptors
MT1
MT2
antagonist
serotonin
5HT2B
5HT2C.
A
subset
was
also
treated
with
lipopolysaccharides
(LPS)
determine
how
additional
neuroinflammation
alters
behavior
affects
response
antidepressant.
Specifically,
were
subjected
14-week
HFD,
during
time
evaluated
twice,
first
at
10th
week
prior
LPS
and/or
agomelatine,
then
14th
after
bi-weekly
exposure
(250
μg/kg)
daily
treatment
(40
mg/kg).
Immediately
second
behavioral
testing
proinflammatory
cytokines
tumor
necrosis
factor
alpha
(TNF-α),
interleukin
6
(IL-6)
1
beta
(IL-1β),
thiobarbituric
acid
reactive
substances
(TABRS),
catalase
(CAT)
glutathione
peroxidase
(GPx),
growth
BDNF,
apoptosis
marker
caspase-3.
Our
results
show
HFD
induced
anxiety-like
open
field
(OFT)
week,
followed
by
forced
swim
(FST)
week.
prefrontal
hippocampal
cortices
noted
overproduction
TNF-α,
IL-6,
IL-1β,
TABRS,
together
increase
caspase-3
activity.
We
observed
decrease
reduced
CAT
GPx
activity
same
areas.
Treatment
reversed
signs
anxiety
depression,
decreased
(TNF-α,
IL-6
IL-1β),
restored
BDNF
levels
antioxidant
enzymes
GPx.
findings
suggest
anxiolytic/antidepressant
obese
could
result
from
reversal
brought
about
their
diet.
Drug and Chemical Toxicology,
Journal Year:
2021,
Volume and Issue:
46(1), P. 97 - 103
Published: Dec. 9, 2021
The
aim
of
the
present
study
was
to
evaluate
protective
effect
gallic
acid
(GA)
against
cisplatin
(CDDP)-induced
ovarian
toxicity,
for
first
time.
damage
generated
with
CDDP
(5
mg/kg)
intraperitoneally
(i.p.)
administration
in
rats.
GA
(2.5
and
5
were
administered
i.p.
3
consecutive
days.
carried
out
main
groups
containing
6
rats
each
group:
control,
mg/kg),
CDDP,
+
mg/kg).
levels
malondialdehyde
(MDA),
total
oxidant
status
(TOS),
antioxidant
(TAS),
oxidative
stress
index
(OSI),
catalase
(CAT),
8-hydroxy-2'-deoxyguanosine
(8-OHdG),
caspase-3
tumor
necrosis
factor-alpha
(TNF-α)
determined.
Hematoxylin
eosin
staining
method
employed
histopathological
examination.
In
group,
it
is
determined
that
statistically
significant
decreasing
TAS
CAT,
increasing
MDA,
TOS,
OSI,
8-OHdG,
TNF-α
(p
<
0.05)
compared
control
group.
administrations
significantly
restored
this
0.05).
Although
vascular
congestion,
edema,
hemorrhage,
follicular
degeneration
leukocyte
infiltration
higher
group
than
these
damages
conclusion,
showed
prevented
CDDP-induced
its
antioxidant,
anti-apoptotic
anti-inflammatory
activities.
More
comprehensive
studies
are
needed
see
underlying
mechanisms.
